Product image of Lercanidipina Sandoz (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipina Sandoz

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipina Sandoz (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lercanidipina Sandoz, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension in adult patients by lowering peripheral vascular resistance.

GNH India supplies Lercanidipina Sandoz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz S.P.A.

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Indications & Clinical Uses

  • Lercanidipine is a dihydropyridine calcium‑channel blocker indicated for the management of high blood pressure.
  • Hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications.

How It Works

  • Lercanidipine selectively inhibits L‑type calcium channels in vascular smooth muscle, preventing calcium influx that is necessary for contraction. This vasodilatory effect decreases peripheral arterial resistance, leading to a reduction in systemic blood pressure without significant negative inotropic activity.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache
  • Flushing
  • Peripheral edema
  • Dizziness

Serious or Rare Side Effects

  • Severe hypotension
  • Hepatic dysfunction
  • Allergic reactions, including angioedema

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Blood pressure monitoring: measure baseline and periodic readings to assess response.
  • Drug interactions: review concomitant medications, especially CYP3A4 inhibitors or inducers.
  • Renal impairment: use with caution in patients with severe renal dysfunction.
  • Pregnancy and lactation: avoid unless benefits outweigh potential risks, as safety data are limited.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lercanidipine can interact with several drug classes; monitoring is advised.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.
  • Concomitant antihypertensives (e.g., other calcium‑channel blockers): risk of excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Grapefruit juice: may modestly raise drug exposure.
  • Diuretics: may enhance orthostatic hypotension.

Frequently Asked Questions

Lercanidipina Sandoz contains lercanidipine hydrochloride, which is prescribed to lower elevated blood pressure in adults diagnosed with hypertension. By reducing peripheral vascular resistance, it helps control systolic and diastolic pressures and lowers the risk of cardiovascular events associated with uncontrolled hypertension.

Lercanidipine selectively blocks L‑type calcium channels in the smooth muscle of arterial walls. This inhibition prevents calcium‑mediated contraction, causing vasodilation of peripheral vessels. The resulting decrease in systemic vascular resistance leads to a reduction in arterial blood pressure.

The appropriate dose is determined by the prescribing clinician based on the individual’s blood pressure, response to therapy, and any co‑existing medical conditions. Physicians typically start with a low dose and may adjust it to achieve target blood pressure while monitoring for tolerability.

Safety data for lercanidipine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any required cold‑chain handling), and import documentation.

Lercanidipine belongs to the dihydropyridine class of calcium‑channel blockers, offering potent vasodilation with a relatively long half‑life, which allows once‑daily dosing. Compared with ACE inhibitors or beta‑blockers, it primarily reduces peripheral resistance without affecting heart rate, making it suitable for patients who need strong arterial relaxation but may be less effective in conditions requiring heart‑rate control.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original blister or container, protect from moisture and direct light, and ensure the packaging remains tightly closed until use.

Lercanidipina Sandoz is taken orally, usually once daily with or without food, as directed by the prescribing physician. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious adverse events, although rare, include severe hypotension, hepatic dysfunction, and hypersensitivity reactions such as angioedema or anaphylaxis. Patients should seek immediate medical attention if they experience sudden dizziness, fainting, jaundice, or swelling of the face, lips, tongue, or throat.

Lercanidipina Sandoz is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation. It should also be avoided in individuals with severe aortic stenosis, unstable angina, or cardiogenic shock, as the vasodilatory effect may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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