Product image of Lercanidipine (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipine

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipine (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipine, is a dihydropyridine calcium channel blocker presented as a tablet for oral use. It lowers elevated blood pressure in adult patients diagnosed with hypertension.\n\nGNH India supplies Lercanidipine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orion Corporation

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Indications & Clinical Uses

  • Lercanidipine is used to manage high blood pressure by relaxing vascular smooth muscle.\n\nHypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications.

How It Works

  • Lercanidipine blocks L‑type calcium channels on vascular smooth‑muscle cells, inhibiting calcium influx. This causes dose‑dependent vasodilation of peripheral arteries, decreasing systemic vascular resistance and ultimately lowering arterial blood pressure without significant negative inotropic effects.

Side Effects

  • Lercanidipine may cause a range of adverse reactions, most of which are mild and reversible.\n\nCommon Side Effects:\n- Headache: mild to moderate intensity.\n- Flushing: transient warmth and redness of the skin.\n- Peripheral edema: swelling of ankles or lower legs.\n- Dizziness or light‑headedness, especially after standing.\n- Tachycardia: increased heart rate.\n- Nausea: occasional stomach upset.\n\nSerious or Rare Side Effects:\n- Severe hypotension: marked drop in blood pressure requiring medical attention.\n- Myocardial infarction: rare but possible in susceptible patients.\n- Hepatic dysfunction: elevated liver enzymes or hepatitis.\n- Allergic reactions: rash, pruritus, or anaphylaxis.\n- Angio‑edema: swelling of face, lips, or throat.\n- Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential risks.\n\nMonitor blood pressure regularly: ensure therapeutic response and avoid excessive lowering.\nAssess hepatic function: dose adjustment may be needed in moderate to severe liver impairment.\nUse caution in the elderly: increased sensitivity to hypotensive effects.\nAvoid abrupt discontinuation: taper dose to prevent rebound hypertension.\nReview concomitant medications: especially other antihypertensives or CYP3A4 inhibitors.\nStore at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

  • Lercanidipine can interact with several drug classes, altering its efficacy or safety profile.\n\nMajor Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase plasma concentrations and risk of hypotension.\n- Simultaneous use with other potent vasodilators (e.g., nitroglycerin): can cause severe blood pressure drops.\n- Grapefruit juice: enhances drug exposure leading to adverse effects.\n\nModerate Interactions (Monitor Closely):\n- Other antihypertensives (e.g., ACE inhibitors, beta‑blockers): may require dose adjustments.\n- Diuretics: can amplify orthostatic hypotension.\n- CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.

Frequently Asked Questions

Lercanidipine is prescribed to treat hypertension, helping to lower elevated systolic and diastolic blood pressure and reduce the risk of cardiovascular events in adult patients.

Lercanidipine selectively blocks L‑type calcium channels in vascular smooth muscle, preventing calcium entry, which leads to relaxation of arterial walls, decreased peripheral resistance, and a reduction in blood pressure.

The appropriate dose of Lercanidipine is determined by the prescribing clinician based on the individual’s blood pressure response, renal and hepatic function, and any concomitant medications.

Safety data for Lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with non‑dihydropyridine calcium channel blockers, Lercanidipine primarily causes vasodilation with minimal effect on heart rate. It offers a once‑daily dosing schedule and a favorable side‑effect profile relative to some older agents, but individual response and tolerability vary.

Lercanidipine tablets should be stored at room temperature, below 25 °C, in the original blister pack or container, protected from moisture and direct sunlight to maintain stability.

Lercanidipine is taken orally, usually once daily, with or without food, as directed by the prescribing physician.

Serious risks include severe hypotension, myocardial infarction, hepatic dysfunction, and rare allergic reactions such as anaphylaxis or angio‑edema. Patients should seek immediate medical attention if they experience symptoms like fainting, chest pain, or swelling of the face or throat.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation, and it should be used with caution in individuals with severe hepatic impairment, unstable angina, or a history of severe hypotension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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