Product image of Lercanidipine Actavis (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipine Actavis

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipine Actavis (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipine Actavis, is a calcium channel blocker presented as a tablet for oral use. It is used to treat hypertension in adult patients.
GNH India supplies Lercanidipine Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Lercanidipine is a dihydropyridine calcium channel blocker indicated for the management of high blood pressure.

  • Hypertension: lowers systolic and diastolic blood pressure, helping to reduce the risk of cardiovascular events.
  • Essential hypertension: provides sustained vasodilation to control chronic elevated blood pressure.
  • Isolated systolic hypertension: improves arterial compliance to manage elevated systolic readings.

How It Works

  • Lercanidipine selectively blocks L‑type calcium channels in vascular smooth muscle, reducing calcium influx. This inhibition leads to relaxation of arterial smooth muscle, resulting in vasodilation and a consequent decrease in peripheral vascular resistance and arterial blood pressure.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: sensation of warmth and redness.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness: especially on standing.
  • Tachycardia: increased heart rate.
  • Fatigue: general feeling of tiredness.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Myocardial infarction: rare cardiac event.
  • Angioedema: swelling of face, lips, or throat.
  • Hepatic injury: abnormal liver function tests.
  • Severe bradycardia: markedly slow heart rate.
  • Anaphylactic reaction: life‑threatening allergic response.

Precautions & Warnings

Patients should be evaluated for safety before initiating therapy and monitored during treatment.

  • Blood pressure monitoring: check regularly to ensure therapeutic targets are met.
  • Liver function assessment: evaluate before starting and during prolonged use.
  • Concomitant antihypertensives: adjust doses to avoid excessive hypotension.
  • Elderly patients: start at lower doses and monitor for orthostatic effects.
  • Discontinuation: avoid abrupt cessation; taper if clinically indicated.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with several drug classes, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels and risk of hypotension.
  • Combined use with other potent antihypertensives (e.g., ACE inhibitors, ARBs): can cause additive blood pressure lowering.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce drug exposure and effectiveness.
  • Grapefruit juice: can modestly increase lercanidipine concentrations.
  • Diuretics: may enhance orthostatic hypotension.
  • Beta‑blockers: may require dose adjustments to maintain hemodynamic stability.

Frequently Asked Questions

Lercanidipine Actavis is prescribed to lower elevated blood pressure in adults with hypertension. By relaxing arterial smooth muscle, it helps achieve target blood pressure levels and reduces the risk of cardiovascular complications associated with sustained hypertension.

Lercanidipine selectively blocks L‑type calcium channels on vascular smooth‑muscle cells. This inhibition reduces calcium entry, causing the muscles to relax, which widens blood vessels (vasodilation) and leads to a decrease in peripheral vascular resistance and blood pressure.

The appropriate dose of Lercanidipine Actavis is determined by the prescribing healthcare professional based on the individual’s blood pressure, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Lercanidipine Actavis in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class, offering once‑daily dosing and a favorable side‑effect profile compared with some older agents. It provides effective blood‑pressure control with fewer reflex tachycardia episodes than non‑dihydropyridine calcium blockers, and it can be combined with other antihypertensives for synergistic effect.

Lercanidipine Actavis tablets should be stored at room temperature, below 25 °C, in the original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Lercanidipine Actavis is taken orally, usually once daily with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious adverse reactions, though rare, can include severe hypotension, myocardial infarction, angioedema, significant liver injury, and anaphylactic reactions. Patients should seek immediate medical attention if they experience symptoms such as sudden dizziness, chest pain, swelling of the face or throat, or signs of liver dysfunction.

Lercanidipine Actavis is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation. Caution is advised for individuals with severe hepatic impairment, unstable angina, or those taking strong CYP3A4 inhibitors, unless a prescriber determines the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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