Product image of Lercanidipine Almus (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipine Almus

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipine Almus (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipine Almus, is a calcium channel blocker presented as an oral tablet for oral use. It lowers elevated blood pressure in adult patients with hypertension.

GNH India supplies Lercanidipine Almus as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Almus France

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Indications & Clinical Uses

Lercanidipine is a dihydropyridine calcium channel blocker indicated for the management of hypertension and related blood‑pressure disorders.

  • Essential hypertension: lowers systolic and diastolic blood pressure.
  • Isolated systolic hypertension: provides vascular relaxation to reduce high systolic values.
  • Hypertension in elderly patients: offers once‑daily dosing with a favorable tolerability profile.

How It Works

  • Lercanidipine selectively antagonizes L-type calcium channels in vascular smooth muscle, inhibiting calcium influx. This leads to relaxation of arterial smooth muscle, vasodilation, and a reduction in peripheral vascular resistance, thereby decreasing systemic blood pressure.

Side Effects

Lercanidipine may be associated with several adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Headache
  • Flushing
  • Peripheral edema
  • Dizziness

Serious or Rare Side Effects

  • Severe hypotension
  • Angioedema
  • Myocardial infarction
  • Hepatic dysfunction

Precautions & Warnings

When prescribing Lercanidipine, clinicians should consider several safety aspects.

  • Blood pressure monitoring: measure BP before initiating therapy and periodically thereafter.
  • Renal impairment: use with caution in patients with severe renal dysfunction.
  • Hepatic impairment: dose adjustment may be required in moderate to severe liver disease.
  • Concomitant antihypertensives: avoid excessive hypotension when combined with other BP‑lowering agents.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Lercanidipine can interact with several drug classes; awareness helps prevent adverse events.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels and risk of hypotension.
  • Grapefruit juice: can elevate drug concentration, leading to excessive blood‑pressure drop.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic efficacy.
  • Other antihypertensives (beta‑blockers, ACE inhibitors): may cause additive hypotensive effect.
  • Diuretics: may increase risk of electrolyte imbalance.

Frequently Asked Questions

Lercanidipine Almus is prescribed to treat hypertension. By lowering elevated systolic and diastolic blood pressure, it helps reduce the risk of cardiovascular complications associated with high blood pressure in adult patients.

Lercanidipine blocks L-type calcium channels in the smooth muscle of arterial walls. This inhibition prevents calcium‑mediated contraction, causing vasodilation, decreasing peripheral resistance, and ultimately lowering systemic blood pressure.

The appropriate dose of Lercanidipine Almus is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any concomitant medications. No fixed regimen is provided here.

Safety of Lercanidipine in pregnancy and lactation has not been established. It should be avoided unless the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both Lercanidipine and amlodipine belong to the dihydropyridine calcium‑channel blocker class and lower blood pressure by vasodilation. Lercanidipine has a longer half‑life, allowing once‑daily dosing, and may exhibit a slightly lower incidence of peripheral edema compared with amlodipine in some studies.

Store Lercanidipine tablets at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability.

Lercanidipine is taken orally, usually as a whole tablet swallowed with a glass of water. It is typically administered once daily, with or without food, as directed by the prescribing clinician.

Serious adverse events include severe hypotension, angioedema, myocardial infarction, and hepatic dysfunction. Patients should be monitored for sudden drops in blood pressure, swelling of the face or throat, chest pain, and signs of liver injury, and seek immediate medical attention if they occur.

Lercanidipine is contraindicated in individuals with known hypersensitivity to the drug, severe aortic stenosis, cardiogenic shock, or uncontrolled heart failure. It should also be avoided in pregnant or breastfeeding women unless clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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