Product image of Lercanidipine Hcl Aurobindo (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipine Hcl Aurobindo

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipine Hcl Aurobindo (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lercanidipine Hcl Aurobindo, is a calcium channel blocker (dihydropyridine) presented as an oral tablet for oral use. It treats hypertension by relaxing vascular smooth muscle and lowering blood pressure.
GNH India supplies Lercanidipine Hcl Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aurobindo Pharma B.V.

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Indications & Clinical Uses

  • Lercanidipine is a calcium channel blocker used to manage conditions related to elevated blood pressure.
  • Hypertension: lowers systolic and diastolic blood pressure in patients with high blood pressure.

How It Works

  • Lercanidipine blocks L-type calcium channels in vascular smooth muscle cells, preventing calcium influx that is required for muscle contraction. This inhibition leads to vasodilation of peripheral arteries, reducing systemic vascular resistance and consequently decreasing arterial blood pressure.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate pain often occurring early in therapy.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the lower limbs due to fluid accumulation.
  • Dizziness: sensation of light‑headedness, especially when standing.
  • Tachycardia: increased heart rate in some patients.
  • Nausea: mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure that may cause fainting.
  • Myocardial infarction: rare occurrence of heart attack.
  • Angioedema: swelling of face, lips, or throat requiring urgent care.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Life‑threatening arrhythmia: abnormal heart rhythm that can be fatal.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient history and monitor for specific concerns.

  • Blood pressure monitoring: regularly assess to ensure therapeutic effect and avoid excessive drop.
  • Cardiovascular assessment: evaluate for underlying heart disease before use.
  • Hepatic impairment: use with caution in patients with liver dysfunction.
  • Pregnancy and lactation: safety not established; avoid unless benefit outweighs risk.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine may interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma concentrations and risk of hypotension.
  • Concomitant use with other antihypertensives: can cause additive blood pressure lowering.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce drug effectiveness.
  • Grapefruit juice: can raise lercanidipine levels, increasing side‑effect risk.
  • NSAIDs: may enhance peripheral edema when combined with lercanidipine.

Frequently Asked Questions

Lercanidipine Hcl Aurobindo is used to treat hypertension. It belongs to the calcium channel blocker class and works by relaxing blood vessels, which helps lower elevated blood pressure in adults diagnosed with high blood pressure.

Lercanidipine blocks L-type calcium channels in the smooth muscle of arteries. By preventing calcium entry, the drug reduces muscle contraction, leading to vasodilation. This widening of blood vessels decreases peripheral resistance and consequently lowers systemic blood pressure.

The appropriate dose of Lercanidipine is determined by the prescribing healthcare professional based on the patient’s condition, response to therapy, and any other medications being taken. Patients should follow the dosage instructions provided by their prescriber.

Safety of Lercanidipine in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Lercanidipine is a dihydropyridine calcium channel blocker, offering once‑daily dosing and a favorable side‑effect profile compared with some older agents. Compared with ACE inhibitors or ARBs, it primarily causes vasodilation without affecting the renin‑angiotensin system, making it a useful alternative or add‑on therapy.

Lercanidipine tablets should be stored at ambient temperature, below 25 °C. Keep them in the original container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Lercanidipine is taken orally, usually once daily with or without food, as directed by the prescribing physician. The tablet should be swallowed whole with a glass of water and not chewed or crushed.

Serious risks include severe hypotension, myocardial infarction, angioedema, and rare cases of hepatic dysfunction or life‑threatening arrhythmias. Patients should seek immediate medical attention if they experience symptoms such as fainting, chest pain, swelling of the face or throat, or unusual liver-related signs.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation. It should also be avoided in individuals with severe aortic stenosis, uncontrolled heart failure, or those taking strong CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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