Product image of Lercanidipine Viatris (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipine Viatris

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipine Viatris (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lercanidipine Viatris, is a calcium channel blocker presented as an oral tablet for oral use. It is used to treat hypertension in adult patients.

GNH India supplies Lercanidipine Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Sante

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Indications & Clinical Uses

Lercanidipine is a dihydropyridine calcium channel blocker indicated for the management of high blood pressure.

  • Hypertension: lowers systolic and diastolic blood pressure in adults with essential hypertension, helping to reduce cardiovascular risk.

How It Works

  • Lercanidipine selectively blocks L‑type calcium channels on vascular smooth muscle cells, inhibiting calcium influx. This causes arterial smooth muscle relaxation, leading to vasodilation and a reduction in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: warm sensation, often on the face.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness: especially on standing.
  • Tachycardia: increased heart rate.
  • Fatigue: general feeling of tiredness.

Serious or Rare Side Effects

  • Angioedema: swelling of lips, tongue, or throat.
  • Severe hypotension: marked drop in blood pressure.
  • Myocardial infarction: rare but serious cardiac event.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Cardiac arrhythmias: irregular heart rhythms.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Blood pressure monitoring: ensure adequate control and avoid excessive drops.
  • Hepatic impairment: dose adjustment may be required.
  • Elderly patients: start at low dose and monitor closely.
  • Concomitant antihypertensives: risk of additive hypotensive effect.
  • CYP3A4 inhibitors: avoid strong inhibitors that may increase exposure.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lercanidipine can interact with several drug classes, influencing its efficacy and safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise plasma levels.
  • Grapefruit juice: can increase drug exposure.
  • Other potent vasodilators: risk of severe hypotension.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampicin): may reduce effectiveness.

  • Diuretics: may enhance antihypertensive effect.
  • Beta‑blockers: additive blood‑pressure lowering.
  • NSAIDs: may blunt antihypertensive response.
  • Digoxin: monitor for potential changes in serum concentration.

Frequently Asked Questions

Lercanidipine Viatris contains the active ingredient lercanidipine hydrochloride, a calcium channel blocker prescribed to lower elevated blood pressure in adults with essential hypertension, thereby helping to reduce the risk of cardiovascular complications.

Lercanidipine selectively blocks L‑type calcium channels on arterial smooth‑muscle cells, preventing calcium entry. This relaxation of vascular smooth muscle leads to vasodilation, decreased peripheral resistance, and a subsequent reduction in systemic blood pressure.

The appropriate dose of lercanidipine is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both lercanidipine and amlodipine belong to the dihydropyridine class of calcium channel blockers and lower blood pressure by vasodilation. Lercanidipine has a longer half‑life and may be associated with a lower incidence of peripheral edema, but individual response varies and the choice depends on clinical judgment.

Lercanidipine tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Lercanidipine is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not crushed or chewed, unless otherwise directed by a healthcare professional.

Serious adverse events, although rare, include angioedema, severe hypotension, myocardial infarction, and significant hepatic dysfunction. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, chest pain, or signs of liver injury.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, uncontrolled heart failure, or those taking strong CYP3A4 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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