Product image of Lercanidipine Viatris (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipine Viatris

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipine Viatris (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipine Viatris, is a calcium‑channel blocker presented as an oral tablet for oral administration. It produces vasodilation of peripheral arteries, thereby reducing elevated systolic and diastolic blood pressure in adult patients diagnosed with hypertension.

GNH India supplies Lercanidipine Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets across the European Union and other regions, and adhering to stringent quality standards through a robust supply chain network.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

  • Lercanidipine belongs to the calcium‑channel blocker class and is used to manage high blood pressure.
  • Hypertension: Lowers systolic and diastolic blood pressure, helping patients achieve recommended target levels.

How It Works

  • Lercanidipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells, inhibiting calcium influx. This results in relaxation of arterial smooth muscle, leading to vasodilation and a consequent reduction in peripheral vascular resistance, which lowers both systolic and diastolic blood pressure.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Flushing: sensation of warmth and redness, usually temporary.
  • Peripheral edema: swelling of ankles or feet due to fluid accumulation.
  • Dizziness: light‑headed feeling, especially when standing quickly.
  • Tachycardia: increased heart rate without other serious symptoms.
  • Palpitations: awareness of heart beating irregularly.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure that may cause fainting.
  • Angioedema: rapid swelling of face, lips, tongue, or throat requiring urgent care.
  • Myocardial infarction: rare occurrence of heart attack symptoms.
  • Elevated liver enzymes: indicating possible hepatic stress.
  • Allergic reactions: rash, itching, or hives that may progress to anaphylaxis.
  • Chest pain: unexplained discomfort that warrants medical evaluation.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety aspects.
  • Monitor blood pressure: ensure adequate control without excessive lowering.
  • Assess hepatic function: use caution in patients with liver impairment.
  • Avoid abrupt discontinuation: tapering may be needed to prevent rebound hypertension.
  • Evaluate cardiovascular disease: patients with severe aortic stenosis may be at higher risk.
  • Use cautiously in the elderly: age‑related pharmacokinetic changes may increase sensitivity.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise plasma concentrations and increase adverse effects.
  • Concurrent use with other potent antihypertensives: can cause excessive hypotension.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may enhance peripheral edema.
  • Grapefruit juice: can increase drug exposure, requiring dose adjustment or monitoring.

Frequently Asked Questions

Lercanidipine is prescribed to lower elevated blood pressure in adults with hypertension. By relaxing arterial smooth muscle, it helps achieve target systolic and diastolic pressures, reducing the risk of cardiovascular complications associated with uncontrolled hypertension.

Lercanidipine blocks L‑type calcium channels in vascular smooth‑muscle cells, preventing calcium entry that is necessary for muscle contraction. This inhibition leads to vasodilation of peripheral arteries, decreasing systemic vascular resistance and consequently lowering blood pressure.

The appropriate dose of Lercanidipine is determined by the prescribing clinician based on the individual’s blood‑pressure response, age, renal and hepatic function, and concomitant medications. The prescriber will select a starting dose and may adjust it to achieve optimal control.

Safety data for Lercanidipine in pregnancy and lactation are limited. It is generally classified as contraindicated or to be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Lercanidipine Viatris. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lercanidipine, a dihydropyridine calcium‑channel blocker, primarily causes arterial vasodilation, whereas agents such as ACE inhibitors reduce angiotensin‑II mediated vasoconstriction and beta‑blockers lower heart rate and contractility. Lercanidipine often provides a smoother blood‑pressure reduction with a lower incidence of reflex tachycardia compared with some older calcium‑channel blockers.

Store Lercanidipine tablets at room temperature, below 25 °C, in the original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability throughout its shelf life.

Lercanidipine is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a full glass of water. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious adverse events, although rare, include severe hypotension, angioedema, myocardial infarction, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, chest pain, or signs of liver dysfunction such as jaundice.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation. It should also be avoided in individuals with severe aortic stenosis, uncontrolled heart failure, or those taking strong CYP3A4 inhibitors without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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