Product image of Lercanidipine Zentiva (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipine Zentiva

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipine Zentiva (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lercanidipine Zentiva, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension in adult patients by lowering elevated blood pressure.
GNH India supplies Lercanidipine Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva France

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Indications & Clinical Uses

Lercanidipine Zentiva is a calcium channel blocker indicated for the management of high blood pressure.

  • Hypertension: Lowers elevated blood pressure, helping to reduce the risk of cardiovascular complications.

How It Works

  • Lercanidipine selectively inhibits L‑type calcium channels in vascular smooth muscle, which prevents calcium influx and leads to arterial vasodilation. The resulting reduction in peripheral vascular resistance lowers systemic blood pressure, providing antihypertensive control without significant negative inotropic effects.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: sensation of warmth and redness.
  • Peripheral edema: swelling of the ankles or feet.
  • Dizziness: especially upon standing.
  • Palpitations: awareness of heartbeat.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, or throat requiring urgent care.
  • Severe hypotension: marked drop in blood pressure causing faintness.
  • Myocardial infarction: rare occurrence of heart attack.
  • Hepatic enzyme elevation: abnormal liver function tests.

Precautions & Warnings

Before initiating therapy with Lercanidipine, consider the following safety measures.

  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic impairment: use with caution; observe liver enzymes.
  • Concomitant antihypertensives: watch for additive blood‑pressure lowering effects.
  • Elderly patients: start at the lowest effective dose and titrate slowly.
  • Pregnancy: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lercanidipine can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: additive hypotensive effect.

  • Diuretics: risk of excessive blood‑pressure reduction.
  • Grapefruit juice: can raise drug exposure and increase side‑effect risk.

Frequently Asked Questions

Lercanidipine Zentiva is prescribed to lower high blood pressure in adults. By relaxing the smooth muscle of blood vessels, it helps maintain normal cardiovascular function and reduces the risk of complications associated with hypertension.

The drug blocks L‑type calcium channels in arterial smooth muscle, preventing calcium entry that would otherwise cause contraction. This selective inhibition leads to vasodilation, decreasing peripheral resistance and consequently lowering systemic blood pressure.

The exact dose is determined by the prescribing clinician based on the patient’s condition, response, and any co‑existing medical issues. Dosage adjustments are made individually and should follow the healthcare professional’s guidance.

Safety data for Lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lercanidipine belongs to the dihydropyridine class of calcium channel blockers, offering once‑daily dosing and a favorable side‑effect profile compared with some older agents. It is often considered when patients need effective blood‑pressure control with minimal impact on heart rate.

Store the tablets at room temperature, below 25 °C, in the original container to protect them from moisture and light. Keep out of reach of children and do not use after the expiry date printed on the packaging.

Lercanidipine Zentiva is taken orally, usually once daily with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew it.

Serious adverse events, although rare, include angioedema, severe hypotension, myocardial infarction, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden faintness, chest pain, or unusual fatigue.

Individuals with known hypersensitivity to lercanidipine or any component of the formulation should avoid the drug. Caution is also advised for patients with severe hepatic impairment, uncontrolled heart failure, or those taking contraindicated medications such as strong CYP3A4 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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