Product image of Lercanidipinhydrochlorid Rivopharm (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipinhydrochlorid Rivopharm

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipinhydrochlorid Rivopharm (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lercanidipinhydrochlorid Rivopharm, is a dihydropyridine calcium‑channel blocker presented as an oral tablet for systemic administration. It is used to lower elevated blood pressure in adult patients with primary hypertension, helping to reduce cardiovascular risk.

GNH India supplies Lercanidipinhydrochlorid Rivopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing for regulated markets.

Manufacturer / TM Owner

Rivopharm Ltd

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Indications & Clinical Uses

  • Lercanidipine Hydrochloride is a calcium‑channel blocker indicated for the management of hypertension, acting on the vascular smooth‑muscle tone to achieve blood‑pressure control.
  • Hypertension: reduces systolic and diastolic blood pressure in adults with primary hypertension.

How It Works

  • Lercanidipine selectively inhibits L‑type calcium channels located on vascular smooth‑muscle cells. This inhibition prevents calcium influx, leading to relaxation of arterial smooth muscle, vasodilation, and a consequent reduction in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Lercanidipine is generally well tolerated, but patients may experience adverse reactions.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: especially upon standing.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Angioedema: swelling of face, lips, tongue, or throat.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Allergic reactions: rash, itching, or urticaria.
  • Cardiac arrhythmia: irregular heart rhythm.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety aspects.
  • Monitor blood pressure: check regularly to ensure therapeutic response.
  • Avoid abrupt discontinuation: taper dose if therapy must be stopped.
  • Caution in hepatic impairment: dose adjustment may be required.
  • Use with caution in the elderly: increased sensitivity to blood‑pressure changes.
  • Pregnancy and lactation: safety not established; prescribe only if benefits outweigh risks.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Lercanidipine may interact with other medicines, necessitating careful review.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.

Moderate Interactions (Monitor Closely):\n- Other antihypertensives: additive blood‑pressure lowering effect.

  • Grapefruit juice: can raise drug exposure.
  • Diuretics: risk of electrolyte imbalance and excessive blood‑pressure reduction.

Frequently Asked Questions

Lercanidipinhydrochlorid Rivopharm contains lercanidipine hydrochloride, an antihypertensive medication used to lower elevated blood pressure in adults with primary hypertension, thereby helping to reduce the risk of cardiovascular events.

Lercanidipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells, preventing calcium entry, which leads to relaxation of arterial walls, vasodilation, and a decrease in peripheral vascular resistance that lowers systemic blood pressure.

The appropriate dose of lercanidipine is determined by the prescribing clinician based on the individual’s blood‑pressure profile, age, renal and hepatic function, and response to therapy. Patients should follow the prescriber’s specific instructions.

Safety of lercanidipine in pregnancy and lactation has not been fully established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both lercanidipine and amlodipine belong to the dihydropyridine class of calcium‑channel blockers and lower blood pressure by vasodilation. Lercanidipine has a longer half‑life and may be associated with a lower incidence of peripheral edema, while amlodipine is more widely studied and available in fixed‑dose combinations.

Lercanidipinhydrochlorid Rivopharm should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Lercanidipine is taken orally as a tablet. The tablet should be swallowed whole with a glass of water, preferably at the same time each day, and may be taken with or without food as directed by the prescriber.

Serious adverse events, although rare, include severe hypotension, angioedema (swelling of the face, lips, tongue, or throat), hepatic dysfunction, and significant cardiac arrhythmias. Patients should seek immediate medical attention if they experience any of these symptoms.

Lercanidipine should be avoided in individuals with known hypersensitivity to the drug or any component of the formulation, in patients with severe hepatic impairment, and in those experiencing uncontrolled hypotension. Clinicians should also assess suitability in patients with certain cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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