Product image of Lercanidipino Mabo (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipino Mabo

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipino Mabo (Lercanidipine Hydrochloride)

Lercanidipine hydrochloride, the active ingredient in Lercanidipino Mabo, is a calcium channel blocker presented as a tablet for oral use. It treats essential hypertension in adult patients.

GNH India supplies Lercanidipino Mabo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mabo-Farma, S.A

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Indications & Clinical Uses

Lercanidipine hydrochloride is used to manage blood pressure by targeting the vascular smooth‑muscle calcium pathway.

  • Essential hypertension: lowers systolic and diastolic pressure to reduce cardiovascular risk in adults.

How It Works

  • Lercanidipine selectively inhibits L‑type calcium channels in vascular smooth muscle, preventing calcium influx that causes contraction. This leads to arterial vasodilation, decreased peripheral resistance, and ultimately a reduction in systemic blood pressure without significant effect on cardiac conduction.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: warmth and redness of the skin.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness: especially when standing quickly.
  • Tiredness: general fatigue.
  • Palpitations: sensation of rapid heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Angio‑edema: swelling of face, lips, or throat.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Allergic reactions: rash, itching, or hives.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor for potential risks.

  • Renal impairment: adjust monitoring frequency.
  • Hepatic disease: evaluate liver function before use.
  • Concomitant antihypertensives: watch for additive blood‑pressure lowering.
  • Elderly patients: start at low dose and titrate cautiously.
  • Pregnancy and lactation: avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase plasma levels and risk of hypotension.
  • Grapefruit juice: can elevate drug concentration.

Moderate Interactions (Monitor Closely):\n- Other antihypertensives (e.g., ACE inhibitors, diuretics): may cause additive blood‑pressure reduction.

  • Simvastatin or other statins metabolized by CYP3A4: monitor for myopathy.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.

Frequently Asked Questions

Lercanidipino Mabo contains lercanidipine hydrochloride, a calcium channel blocker indicated for the treatment of essential hypertension in adult patients. By lowering blood pressure, it helps reduce the risk of cardiovascular events such as stroke and heart attack.

Lercanidipine selectively blocks L‑type calcium channels in the smooth muscle of arterial walls. This inhibition prevents calcium‑mediated contraction, causing the vessels to relax and dilate. The resulting decrease in peripheral vascular resistance leads to lower systemic blood pressure.

The appropriate dose of Lercanidipino Mabo is determined by the prescribing healthcare professional based on the patient’s clinical condition, response to therapy, and any comorbidities. Dosage adjustments are made according to individual therapeutic needs.

Safety of lercanidipine during pregnancy or lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both lercanidipine and amlodipine are dihydropyridine calcium channel blockers that lower blood pressure by vasodilation. Lercanidipine has a longer half‑life and may provide smoother blood‑pressure control with a lower incidence of reflex tachycardia, while amlodipine is more widely used and has an extensive safety record.

Store Lercanidipino Mabo at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain stability and potency.

Lercanidipino Mabo is taken orally, usually once daily with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious adverse events, though rare, include severe hypotension, angio‑edema, and hepatic dysfunction. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, or signs of liver injury such as jaundice.

Lercanidipino Mabo is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation. It should also be avoided in individuals with severe aortic stenosis or uncontrolled heart failure unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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