Product image of Lercanidipino Ratiopharm (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipino Ratiopharm

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipino Ratiopharm (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipino Ratiopharm, is a calcium channel blocker presented as a tablet for oral use. It is prescribed to lower high blood pressure in adults with essential hypertension and is available in the European Union market, conforming to EU pharmaceutical standards.

GNH India supplies Lercanidipino Ratiopharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality compliance and reliable delivery across global markets.

Manufacturer / TM Owner

Teva Pharma S.L.U.,

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Indications & Clinical Uses

  • Lercanidipine is used as an antihypertensive agent acting on the vascular smooth muscle to control blood pressure.
  • Essential hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications.
  • Isolated systolic hypertension: provides effective blood pressure control especially in elderly patients.

How It Works

  • Lercanidipine selectively blocks L-type calcium channels in vascular smooth muscle cells, inhibiting calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation and a consequent reduction in peripheral vascular resistance, which lowers systemic blood pressure without significant effect on heart rate.

Side Effects

Lercanidipine may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Headache
  • Flushing
  • Peripheral edema
  • Dizziness
  • Tachycardia
  • Nausea

Serious or Rare Side Effects

  • Severe hypotension
  • Myocardial infarction
  • Cardiac arrhythmia
  • Angioedema
  • Hepatic dysfunction
  • Allergic reactions (e.g., rash, urticaria)

Precautions & Warnings

  • Before prescribing Lercanidipine, consider the following precautions.
  • Renal impairment: adjust therapy and monitor renal function.
  • Hepatic dysfunction: monitor liver enzymes and consider dose modification.
  • Concomitant use with strong CYP3A4 inhibitors: avoid or reduce dose to prevent toxicity.
  • Pregnancy and lactation: use only if clearly needed, as safety data are limited.
  • Elderly patients: start with a low dose and monitor blood pressure closely.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Lercanidipine can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels leading to toxicity.
  • Grapefruit juice: can markedly raise drug concentration.
  • Other antihypertensives (e.g., ACE inhibitors, ARBs): risk of excessive hypotension.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Diuretics: may enhance hypotensive effect.
  • Beta‑blockers: additive blood pressure lowering.

Frequently Asked Questions

Lercanidipino Ratiopharm contains lercanidipine, a calcium channel blocker indicated for the treatment of essential hypertension. By lowering elevated blood pressure, it helps reduce the risk of cardiovascular events such as stroke and heart attack in adult patients.

Lercanidipine selectively inhibits L-type calcium channels in arterial smooth muscle. This blocks calcium entry, causing the vessels to relax and dilate, which decreases peripheral vascular resistance and results in a reduction of systemic blood pressure.

The appropriate dose of Lercanidipino Ratiopharm is determined by the prescribing clinician based on the patient’s blood pressure, age, renal and hepatic function, and concomitant medications. The prescriber will select the starting dose and any subsequent adjustments.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and the necessary import documentation.

Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class, offering potent vasodilation with a relatively low effect on heart rate. Compared with agents such as amlodipine, it has a similar efficacy profile but may differ in pharmacokinetic properties and side‑effect frequency, which the prescriber will consider.

Store the tablets at ambient temperature, preferably below 25 °C, in their original packaging. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

Lercanidipino Ratiopharm is taken orally, usually once daily. It can be swallowed with or without food, but patients should follow the specific instructions provided by their healthcare professional.

Serious risks include severe hypotension, angioedema, myocardial infarction, and cardiac arrhythmias. Patients should be advised to seek immediate medical attention if they experience symptoms such as sudden dizziness, swelling of the face or throat, chest pain, or irregular heartbeat.

Lercanidipino Ratiopharm is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation, as well as in individuals with severe aortic stenosis or uncontrolled heart failure. The prescriber should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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