Product image of Lercanidipino Recordati (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipino Recordati

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipino Recordati (Lercanidipine Hydrochloride)

Lercanidipine hydrochloride, the active ingredient in Lercanidipino Recordati, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to treat hypertension in adult patients by relaxing vascular smooth muscle and lowering peripheral resistance.

GNH India supplies Lercanidipino Recordati as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Casen Recordati, S.L.

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Indications & Clinical Uses

  • Lercanidipine is indicated for the management of hypertension, a condition characterized by elevated arterial pressure.
  • Hypertension: reduces systolic and diastolic blood pressure by relaxing peripheral arteries.

How It Works

  • Lercanidipine hydrochloride selectively blocks L-type calcium channels in vascular smooth muscle cells. Inhibition of calcium influx prevents contraction of the smooth muscle, leading to vasodilation, decreased peripheral vascular resistance, and ultimately a reduction in systemic blood pressure.

Side Effects

Lercanidipine may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate head pain often occurring early in therapy.
  • Flushing: transient warmth and reddening of the skin, especially on the face.
  • Peripheral edema: swelling of the ankles or feet due to fluid accumulation.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure that can cause dizziness or fainting.
  • Angioedema: swelling of the face, lips, tongue, or throat that may compromise breathing.
  • Liver enzyme elevation: abnormal hepatic function tests indicating possible liver involvement.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety factors.

  • Dose adjustment: consider lower starting doses in elderly patients.
  • Renal impairment: monitor kidney function and adjust if necessary.
  • Hepatic impairment: use with caution and observe liver enzymes.
  • Concomitant antihypertensives: risk of additive blood‑pressure lowering effects.
  • Pregnancy: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Lercanidipine can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels.
  • Grapefruit juice: can elevate drug concentration and enhance hypotensive effect.
  • Other calcium channel blockers: additive vasodilatory action may cause excessive hypotension.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance antihypertensive effect and lead to electrolyte imbalance.
  • Beta‑blockers: combined effect on blood pressure warrants close monitoring.
  • ACE inhibitors/ARBs: monitor renal function and potassium levels when used together.

Frequently Asked Questions

Lercanidipino Recordati contains lercanidipine hydrochloride, which is prescribed to lower high blood pressure in adults. By relaxing the smooth muscle of blood vessels, it helps achieve and maintain target blood‑pressure levels, reducing the risk of cardiovascular complications associated with hypertension.

Lercanidipine selectively blocks L‑type calcium channels in vascular smooth‑muscle cells. This inhibition prevents calcium‑dependent contraction, causing the vessels to dilate. The resulting decrease in peripheral vascular resistance leads to a reduction in systolic and diastolic blood pressure.

The appropriate dose is determined by the prescribing clinician based on the individual’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. The prescriber will select the starting dose and any subsequent adjustments according to clinical response and tolerability.

Safety data for lercanidipine in pregnancy are limited, and the product is generally not recommended unless the potential benefit justifies the potential risk to the fetus. Likewise, it is not known whether the drug is excreted in human milk; caution is advised for nursing mothers.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class, offering a long‑acting vasodilatory effect with once‑daily dosing. Compared with agents such as amlodipine, it has a similar efficacy profile but may differ in pharmacokinetic properties, tolerability, and specific drug‑interaction potential, which clinicians consider when individualising therapy.

Store the tablets at ambient temperature, preferably below 25 °C. Keep them in the original container, protect from moisture, heat and direct sunlight. Do not use the product after the expiry date printed on the packaging.

The medication is taken orally, usually once daily, with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious adverse events, although rare, include severe hypotension, angioedema (swelling of the face, lips, tongue or throat), and significant liver‑enzyme elevations. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the airway, or signs of liver dysfunction such as jaundice.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation. It should also be avoided in individuals with severe aortic stenosis, unstable angina, or those taking strong CYP3A4 inhibitors without appropriate dose adjustment and monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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