Product image of Lercanidipino Tevagen (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipino Tevagen

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipino Tevagen (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipino Tevagen, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension by relaxing vascular smooth muscle and lowering peripheral resistance.
GNH India supplies Lercanidipino Tevagen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma S.L.U.,

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Indications & Clinical Uses

  • Lercanidipino Tevagen is a calcium‑channel‑blocking antihypertensive that lowers elevated blood pressure.
  • Hypertension: lowers systolic and diastolic pressure in patients with primary hypertension.
  • Isolated systolic hypertension: helps control elevated systolic pressure when diastolic values are normal.
  • Essential hypertension: reduces cardiovascular risk by maintaining target blood pressure levels.

How It Works

  • Lercanidipine selectively inhibits L‑type calcium channels in vascular smooth muscle, preventing calcium influx that is necessary for contraction. This leads to arterial vasodilation, decreased peripheral vascular resistance, and ultimately a reduction in systemic blood pressure without significant effect on cardiac contractility.

Side Effects

Lercanidipino Tevagen may cause a range of adverse reactions. Patients should be aware of both frequent and rare events.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Flushing: sensation of warmth and redness, usually resolves spontaneously.
  • Peripheral edema: swelling of ankles or feet, may require monitoring.
  • Dizziness: especially upon standing, related to blood pressure lowering.
  • Fatigue: general tiredness without specific cause.
  • Tachycardia: increased heart rate in some individuals.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Myocardial infarction: rare occurrence of heart attack.
  • Arrhythmia: abnormal heart rhythms, potentially life‑threatening.
  • Angioedema: swelling of face, lips, tongue, or throat.
  • Hepatic enzyme elevation: abnormal liver function tests.

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety factors.
  • Monitor blood pressure: ensure target levels are achieved without excessive drop.
  • Assess renal function: adjust use in patients with severe renal impairment.
  • Avoid abrupt discontinuation: sudden stop may cause rebound hypertension.
  • Use with caution in elderly: increased sensitivity to hypotensive effects.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light.

Avoid Interactions

Lercanidipino Tevagen can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampicin): may reduce therapeutic effect.
  • Grapefruit juice: can raise drug levels and risk of hypotension.

Moderate Interactions (Monitor Closely)

  • Diuretics: additive blood‑pressure‑lowering effect, may require dose adjustment.
  • Beta‑blockers: combined use can enhance hypotensive response.

Frequently Asked Questions

Lercanidipino Tevagen contains lercanidipine, a calcium‑channel blocker indicated for the treatment of hypertension. It helps lower elevated systolic and diastolic blood pressure by relaxing arterial smooth muscle, thereby reducing peripheral vascular resistance.

Lercanidipine selectively blocks L‑type calcium channels on vascular smooth‑muscle cells. By preventing calcium entry, it inhibits muscle contraction, causing arterial vasodilation. The resulting decrease in peripheral resistance leads to a reduction in systemic blood pressure.

The appropriate dose of Lercanidipino Tevagen is determined by the prescribing clinician based on the patient’s blood‑pressure profile, age, renal function, and concomitant therapies. Dosage adjustments are made to achieve target blood‑pressure goals while minimizing side effects.

Safety data for lercanidipine in pregnancy and lactation are limited, and the product is not classified in a specific pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and a healthcare professional should be consulted.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class and offers a long‑acting vasodilatory effect. Compared with amlodipine, another dihydropyridine, lercanidipine may have a slightly lower incidence of peripheral edema, but both share similar efficacy in lowering blood pressure.

Lercanidipino Tevagen should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

The medication is taken orally, usually once daily, with or without food. Patients should swallow the tablet whole with a glass of water and follow the dosing schedule prescribed by their healthcare provider.

Serious adverse events, although rare, include severe hypotension, myocardial infarction, arrhythmias, angioedema, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience symptoms such as faintness, chest pain, irregular heartbeat, swelling of the face or throat, or jaundice.

Lercanidipino Tevagen is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation, as well as in individuals with severe hypotension, cardiogenic shock, or unstable angina. Clinicians should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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