Product image of Lercanidipino Viatris (Lercanidipine Hydrochloride) supplied by GNH India

Lercanidipino Viatris

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanidipino Viatris (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lercanidipino Viatris, is a calcium channel blocker presented as an oral tablet for oral use. It is indicated for the management of hypertension in adult patients.
GNH India supplies Lercanidipino Viatris as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Limited

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Indications & Clinical Uses

  • Lercanidipine is a dihydropyridine calcium‑channel blocker used to treat conditions related to elevated arterial pressure.
  • Hypertension: lowers systolic and diastolic blood pressure in patients with primary hypertension.

How It Works

  • Lercanidipine selectively inhibits L‑type calcium channels in vascular smooth muscle, reducing calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation, decreased peripheral vascular resistance, and ultimately a reduction in systemic blood pressure.

Side Effects

Lercanidipine may be associated with a range of adverse reactions. Patients should be informed of both frequent and uncommon events.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Flushing: warmth and redness, typically occurring shortly after dosing.
  • Peripheral edema: swelling of the ankles or feet.
  • Dizziness or light‑headedness, especially when standing quickly.
  • Tachycardia or palpitations.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Angioedema: swelling of face, lips, tongue, or throat.
  • Myocardial infarction: chest pain or discomfort suggestive of heart attack.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Anaphylactic reaction: rapid onset of breathing difficulty, hives, or shock.

Precautions & Warnings

Before initiating therapy with lercanidipine, clinicians should consider several safety aspects.

  • Blood pressure monitoring: ensure adequate control and avoid excessive hypotension.
  • Hepatic impairment: dose adjustment may be required in patients with liver dysfunction.
  • Elderly patients: start at the lowest effective dose and monitor for orthostatic effects.
  • Concomitant antihypertensives: assess risk of additive blood‑pressure lowering.
  • Severe hypotension: contraindicated in patients with markedly low blood pressure.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase plasma concentrations and risk of hypotension.
  • Co‑administration with other potent antihypertensives: can cause excessive blood‑pressure reduction.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may lower drug exposure and reduce effectiveness.
  • Grapefruit juice: can raise lercanidipine levels, enhancing side effects.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may blunt antihypertensive response.
  • Diuretics: may increase risk of electrolyte disturbances when combined.
  • Beta‑blockers: monitor for additive bradycardia or AV‑block.

Frequently Asked Questions

Lercanidipino Viatris contains lercanidipine, a calcium‑channel blocker that is prescribed to lower high blood pressure in adults with primary hypertension. By reducing arterial resistance, it helps achieve target blood‑pressure levels and lowers the risk of cardiovascular complications.

Lercanidipine selectively blocks L‑type calcium channels in the smooth muscle of arteries. This inhibition reduces calcium entry into the cells, causing the muscle to relax, which widens the blood vessels (vasodilation). The resulting decrease in peripheral vascular resistance leads to lower systolic and diastolic blood pressure.

The exact dose of lercanidipine is determined by the prescribing clinician based on the patient’s blood‑pressure readings, age, renal and hepatic function, and concomitant medications. The prescriber will select the appropriate strength and titrate as needed to achieve optimal control.

Safety data for lercanidipine in pregnancy and lactation are limited, and the product is generally not recommended unless the potential benefit outweighs the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Lercanidipine belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or ARBs, it may produce fewer cough or angio‑edema issues but can be associated with peripheral edema. Choice of therapy depends on patient comorbidities, tolerability, and physician preference.

Lercanidipino Viatris should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout its shelf life.

The medication is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water and do not crush or chew it unless instructed otherwise.

Serious adverse events, though rare, include severe hypotension, angio‑edema, myocardial infarction, hepatic dysfunction, and anaphylactic reactions. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, chest pain, or signs of liver injury.

Lercanidipine is contraindicated in patients with known hypersensitivity to the drug or any component of the formulation, and in individuals with severe hypotension (blood pressure markedly below normal). Caution is also advised for patients with significant hepatic impairment or those taking strong CYP3A4 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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