Product image of Lercanil (Lercanidipine Hydrochloride) supplied by GNH India

Lercanil

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercanil (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lercanil, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to lower elevated blood pressure in adult patients with hypertension. The drug inhibits L‑type calcium channels in vascular smooth muscle, producing vasodilation and decreasing systemic vascular resistance.

GNH India supplies Lercanil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance, regulatory compliance, and reliable logistics for global distribution through its established network of partners.

Manufacturer / TM Owner

Berlin-Chemie Menarini Hrvatska D.O.O.

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Indications & Clinical Uses

  • Lercanil is a calcium channel blocker indicated for the management of hypertension, acting on the vascular smooth‑muscle tone to lower blood pressure.
  • Hypertension: reduces systolic and diastolic blood pressure, helping patients achieve target levels and decreasing the risk of cardiovascular complications.

How It Works

  • Lercanidipine Hydrochloride selectively blocks L‑type calcium channels located on vascular smooth‑muscle cells. By preventing calcium influx, it relaxes arterial smooth muscle, leading to vasodilation, decreased peripheral resistance, and a consequent reduction in systemic blood pressure. The drug’s high lipophilicity allows prolonged action and a once‑daily dosing profile. It exhibits a gradual onset of action and maintains therapeutic plasma concentrations over 24 hours, supporting consistent antihypertensive effect.

Side Effects

Lercanidipine may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Headache: mild to moderate intensity, often transient.
  • Flushing: sensation of warmth, usually temporary.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness: may occur upon standing.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Angioedema: swelling of face, lips, tongue, or throat.
  • Hepatic dysfunction: abnormal liver enzymes or jaundice.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Blood pressure monitoring: regularly assess to avoid excessive hypotension.
  • Hepatic impairment: use with caution; dose adjustment may be needed.
  • Elderly patients: start at lower dose and monitor for dizziness.
  • Concomitant antihypertensives: evaluate risk of additive blood pressure lowering.
  • CYP3A4 inhibitors: avoid strong inhibitors that may increase drug exposure.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Lercanil can interact with other medicines, influencing its efficacy and safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may raise plasma levels and increase adverse effects.
  • Combined use with other potent antihypertensives: risk of severe hypotension.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampicin): may reduce effectiveness.

  • Grapefruit juice: can modestly increase drug exposure.
  • Diuretics: may enhance blood pressure lowering.
  • NSAIDs: may attenuate antihypertensive effect.

Frequently Asked Questions

Lercanil contains Lercanidipine Hydrochloride, a calcium channel blocker indicated for the treatment of hypertension. It helps lower elevated blood pressure in adult patients, reducing the risk of cardiovascular events associated with uncontrolled hypertension.

Lercanidipine Hydrochloride selectively inhibits L‑type calcium channels on vascular smooth‑muscle cells. This blockade prevents calcium entry, causing relaxation of arterial smooth muscle, vasodilation, and a reduction in peripheral vascular resistance, which together lower systemic blood pressure.

The appropriate dose of Lercanil is determined by the prescribing healthcare professional based on the individual’s blood pressure response, age, renal and hepatic function, and concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Lercanil in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Lercanil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will provide pricing, availability, shipping details, and any required import documentation.

Lercanil belongs to the calcium channel blocker class, offering once‑daily dosing and a favorable side‑effect profile compared with some beta‑blockers or diuretics. Its high lipophilicity provides a prolonged duration of action, making it an effective option for patients who need consistent blood‑pressure control.

Lercanil should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and direct sunlight to maintain stability throughout its shelf life.

Lercanil is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events, though rare, include severe hypotension, angioedema, and hepatic dysfunction. Patients should seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, or signs of liver injury such as jaundice or dark urine.

Lercanil is contraindicated in patients with known hypersensitivity to Lercanidipine or any component of the formulation. Caution is advised in individuals with severe hepatic impairment, uncontrolled heart failure, or those taking strong CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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