Product image of Lercapress (Lercanidipine Hydrochloride) supplied by GNH India

Lercapress

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercapress (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lercapress, is a calcium channel blocker presented as an oral tablet for oral use. It treats hypertension in adult patients by relaxing vascular smooth muscle and lowering blood pressure.

GNH India supplies Lercapress as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Lercapress is a calcium‑channel‑blocking antihypertensive used to manage elevated blood pressure.
  • Hypertension: lowers systolic and diastolic pressure, helping to reduce the risk of stroke, myocardial infarction and other cardiovascular complications.

How It Works

  • Lercanidipine hydrochloride selectively blocks L‑type calcium channels in vascular smooth muscle. By inhibiting calcium influx, it prevents contraction of arterial walls, producing dose‑dependent vasodilation. The resulting reduction in peripheral vascular resistance leads to a sustained decrease in systemic blood pressure without significant negative inotropic effects on the heart.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Headache
  • Flushing
  • Peripheral edema
  • Dizziness
  • Tachycardia
  • Fatigue

Serious or Rare Side Effects

  • Severe hypotension
  • Myocardial infarction
  • Angioedema
  • Hepatic injury
  • Life‑threatening arrhythmias

Precautions & Warnings

Patients should be monitored for blood‑pressure response and potential adverse events.

  • Blood pressure monitoring: check regularly after initiation and dose adjustments.
  • Hepatic impairment: use with caution; dose may need adjustment.
  • Elderly patients: start at lower dose and titrate slowly.
  • Concomitant antihypertensives: assess for additive hypotensive effect.
  • Hypersensitivity: discontinue if allergic reaction occurs.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lercapress can interact with several drug classes; clinical judgment is required.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels.
  • Other potent antihypertensives: risk of excessive hypotension.
  • Grapefruit juice: can elevate drug exposure.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce efficacy.

  • Diuretics: may enhance electrolyte disturbances.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may attenuate blood‑pressure‑lowering effect.

Frequently Asked Questions

Lercapress contains lercanidipine hydrochloride, a calcium‑channel blocker prescribed to lower high blood pressure in adult patients. By relaxing arterial smooth muscle, it helps achieve target blood‑pressure levels and reduces the risk of cardiovascular events associated with hypertension.

Lercanidipine selectively inhibits L‑type calcium channels on vascular smooth‑muscle cells. This blocks calcium entry, preventing muscle contraction and causing dose‑dependent vasodilation. The resulting fall in peripheral resistance leads to a sustained reduction in systemic blood pressure.

The appropriate dose of Lercapress is determined by the prescribing clinician based on the patient’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. Dosage adjustments are individualized and should follow the prescriber’s instructions.

Safety data for lercanidipine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lercapress belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or beta‑blockers, it has a lower incidence of cough and may be better tolerated in patients with reactive airway disease, but it can cause peripheral edema more frequently.

Lercapress tablets should be stored at temperatures below 25 °C, in the original container, protected from moisture and direct sunlight. Do not store in humid environments such as bathrooms or near heat sources.

Lercapress is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious adverse events, although rare, include severe hypotension, myocardial infarction, angioedema and life‑threatening arrhythmias. Patients should seek immediate medical attention if they experience sudden dizziness, chest pain, swelling of the face or throat, or irregular heartbeats.

Lercapress is contraindicated in individuals with known hypersensitivity to lercanidipine or any component of the formulation. It should also be avoided in patients with severe aortic stenosis or uncontrolled heart failure unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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