Product image of Lercaril (Enalapril Maleate, Lercanidipine Hydrochloride) supplied by GNH India

Lercaril

Active Ingredient:
Enalapril Maleate, Lercanidipine Hydrochloride
Origin:
EU

Lercaril (Enalapril Maleate, Lercanidipine Hydrochloride)

Enalapril maleate and lercanidipine hydrochloride, the active ingredients in Lercaril, are an ACE inhibitor and a dihydropyridine calcium‑channel blocker presented as a tablet for oral use. They lower elevated blood pressure in adult patients with hypertension and provide a combined therapeutic approach that improves vascular tone and reduces cardiovascular risk.

GNH India supplies Lercaril as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable logistics for cross‑border medication distribution.

Manufacturer / TM Owner

Recordati Ireland Ltd.

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Indications & Clinical Uses

  • Lercaril combines an ACE inhibitor and a calcium‑channel blocker to treat hypertension, a condition characterized by persistently high arterial pressure.
  • Hypertension: reduces systolic and diastolic blood pressure in patients with primary hypertension.
  • Essential hypertension: provides additive blood‑pressure control when monotherapy is insufficient.
  • High blood pressure: improves overall cardiovascular risk profile by targeting two complementary pathways.

How It Works

  • Enalapril maleate inhibits angiotensin‑converting enzyme, decreasing formation of angiotensin II and reducing vasoconstriction and aldosterone release. Lercanidipine hydrochloride blocks L‑type calcium channels in vascular smooth muscle, leading to arterial vasodilation. The dual action yields additive reduction of peripheral resistance and blood pressure.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Headache, often mild and transient.
  • Flushing or warmth sensation.
  • Peripheral edema, typically mild swelling of the ankles.
  • Persistent dry cough, characteristic of ACE inhibition.
  • Fatigue or general weakness.

Serious or Rare Side Effects

  • Angioedema involving face, lips, tongue or airway.
  • Severe hypotension causing fainting or shock.
  • Hepatic dysfunction with elevated liver enzymes.
  • Acute myocardial infarction or worsening heart failure.
  • Life‑threatening arrhythmias.
  • Acute renal failure, especially in patients with pre‑existing kidney disease.

Precautions & Warnings

  • Before initiating therapy, clinicians should assess baseline blood pressure, renal function and electrolyte status.
  • Monitor blood pressure regularly to avoid excessive hypotension.
  • Assess renal function periodically, especially in patients with chronic kidney disease.
  • Check serum potassium and sodium levels when combined with diuretics.
  • Use caution in patients with hepatic impairment or a history of angioedema.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lercaril may interact with several drug classes that affect blood pressure or electrolyte balance.

Major Interactions (Avoid)

  • Concomitant use of aliskiren in diabetic patients.
  • Potassium‑sparing diuretics that increase serum potassium.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs) that may blunt antihypertensive effect.

Moderate Interactions (Monitor Closely):\n- Thiazide diuretics, which can enhance hypotensive response.

  • Strong CYP3A4 inhibitors or inducers that may alter lercanidipine levels.

Frequently Asked Questions

Lercaril is prescribed to lower high blood pressure in adult patients. It combines two agents—an ACE inhibitor and a calcium‑channel blocker—to provide additive blood‑pressure reduction, making it suitable for individuals whose hypertension is not adequately controlled with a single medication.

The enalapril component blocks the angiotensin‑converting enzyme, reducing angiotensin II levels and decreasing vasoconstriction. Lercanidipine blocks L‑type calcium channels in vascular smooth muscle, causing arterial dilation. Together, they lower peripheral resistance and help maintain normal blood‑pressure levels.

The specific dose of Lercaril is determined by the prescribing clinician based on the patient’s blood‑pressure readings, overall health status, and any concurrent medications. Dosage adjustments are made to achieve target blood‑pressure goals while minimizing side effects.

Safety of Lercaril in pregnancy or while breastfeeding has not been fully established. ACE inhibitors are generally avoided during the second and third trimesters because of potential fetal harm. Patients who are pregnant, planning pregnancy, or nursing should discuss alternatives with their healthcare provider.

To request Lercaril, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike monotherapy agents, Lercaril delivers a fixed‑dose combination of an ACE inhibitor and a calcium‑channel blocker, offering broader blood‑pressure control through two mechanisms. This can improve efficacy and simplify regimens compared with taking two separate tablets, while maintaining a comparable safety profile.

Lercaril tablets should be stored at temperatures below 25 °C, in the original packaging, and protected from moisture and direct sunlight. Keeping the product in a dry, cool environment helps preserve its potency throughout its shelf life.

Lercaril is taken orally, usually once daily, with or without food as directed by the prescriber. The tablet should be swallowed whole with a glass of water and not crushed or chewed unless specifically advised by a healthcare professional.

Serious risks include angioedema, which can cause swelling of the face, lips, tongue or airway, and severe hypotension leading to dizziness or fainting. Patients should seek immediate medical attention if they experience rapid swelling, difficulty breathing, or a sudden drop in blood pressure.

Lercaril is contraindicated in individuals with a known hypersensitivity to enalapril, lercanidipine, or any component of the formulation. It should also be avoided in patients with a history of angioedema related to ACE‑inhibitor therapy and in those with severe renal or hepatic impairment unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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