Product image of Lercatio (Lercanidipine Hydrochloride) supplied by GNH India

Lercatio

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lercatio (Lercanidipine Hydrochloride)

Lercanidipine Hydrochloride, the active ingredient in Lercatio, is a calcium channel blocker presented as an oral dosage form for oral use. It is employed to lower elevated blood pressure in adult patients with hypertension.
GNH India supplies Lercatio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hexal A/S

1
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Indications & Clinical Uses

  • Lercatio belongs to the calcium channel blocker class and is used to manage high blood pressure.
  • Hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications associated with sustained hypertension.

How It Works

  • Lercanidipine Hydrochloride selectively inhibits calcium influx through L‑type calcium channels located on vascular smooth muscle cells. By blocking these channels, it prevents calcium‑dependent contraction, leading to relaxation of arterial smooth muscle, vasodilation, and a consequent reduction in peripheral vascular resistance and arterial blood pressure.

Side Effects

Lercatio may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Headache: mild to moderate intensity, often occurring early in therapy.
  • Flushing: sensation of warmth and redness, usually transient.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness: especially when standing quickly.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure requiring medical attention.
  • Hepatic dysfunction: abnormal liver enzyme elevations.
  • Allergic reactions: rash, pruritus, or angioedema.
  • Cardiac arrhythmias: irregular heart rhythms in susceptible individuals.

Precautions & Warnings

Before initiating therapy, certain considerations are recommended.

  • Renal impairment: assess kidney function and adjust therapy if needed.
  • Hepatic disease: monitor liver enzymes and use with caution.
  • Concomitant antihypertensives: avoid excessive blood pressure lowering.
  • Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lercatio can interact with several medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase lercanidipine plasma levels, raising risk of hypotension.
  • Grapefruit juice: can elevate drug concentration, leading to excessive vasodilation.

Moderate Interactions (Monitor Closely):\n- Other antihypertensives (e.g., ACE inhibitors, diuretics): may cause additive blood pressure reduction.

  • Simvastatin: lercanidipine may increase statin exposure, raising risk of myopathy.
  • Beta‑blockers: combined effect on heart rate and blood pressure should be monitored.

Frequently Asked Questions

Lercatio contains lercanidipine hydrochloride, a calcium channel blocker prescribed to lower high blood pressure in adults diagnosed with hypertension. By reducing vascular resistance, it helps prevent complications such as stroke, heart attack, and kidney damage associated with uncontrolled hypertension.

Lercanidipine selectively blocks L‑type calcium channels on arterial smooth‑muscle cells. This inhibition prevents calcium‑driven contraction, causing the blood vessels to relax and widen (vasodilation). The resulting drop in peripheral resistance lowers both systolic and diastolic blood pressure.

The appropriate dose of Lercatio is determined by the prescribing healthcare professional based on the individual’s blood pressure, response to therapy, and any co‑existing medical conditions. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of lercanidipine in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To request Lercatio, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lercatio belongs to the dihydropyridine calcium‑channel blocker class, which primarily causes arterial vasodilation. Compared with ACE inhibitors or beta‑blockers, it has a lower incidence of cough but may be more likely to cause peripheral edema. Choice of therapy depends on patient profile, comorbidities, and tolerability.

Lercatio should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight. Do not store in bathrooms or near kitchen appliances that generate heat.

Lercatio is taken orally, usually once daily, with or without food. Swallow the tablet whole with a glass of water. Patients should follow the dosing schedule prescribed by their healthcare provider and avoid missing doses.

Serious risks include severe hypotension, which can cause fainting or shock, and rare hepatic dysfunction manifested by elevated liver enzymes. Allergic reactions such as rash, angioedema, or anaphylaxis may also occur. Any sudden or severe symptoms should prompt immediate medical evaluation.

Lercatio is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation. It should also be avoided in individuals with severe aortic stenosis, cardiogenic shock, or uncontrolled heart failure, as the vasodilatory effect may worsen these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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