Product image of Lercaton Plus (Enalapril Maleate, Lercanidipine Hydrochloride) supplied by GNH India

Lercaton Plus

Active Ingredient:
Enalapril Maleate, Lercanidipine Hydrochloride
Origin:
EU

Lercaton Plus (Enalapril Maleate, Lercanidipine Hydrochloride)

Enalapril maleate and lercanidipine hydrochloride, the active ingredients in Lercaton Plus, are an ACE inhibitor and calcium channel blocker combination presented as a tablet for oral use. It treats hypertension in adult patients.

GNH India supplies Lercaton Plus as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Lercaton Plus is an antihypertensive medication that acts on the renin‑angiotensin system and vascular smooth‑muscle calcium channels.

  • Essential hypertension: lowers systolic and diastolic blood pressure to target levels.
  • Secondary hypertension: assists in controlling elevated blood pressure due to underlying causes.
  • Isolated systolic hypertension: helps achieve recommended systolic pressure goals.

How It Works

  • Enalapril maleate inhibits angiotensin‑converting enzyme, reducing formation of angiotensin II and decreasing vasoconstriction. Lercanidipine hydrochloride blocks L‑type calcium channels in vascular smooth muscle, producing vasodilation. The combined actions result in reduced peripheral resistance and lowered arterial pressure.

Side Effects

Common Side Effects

  • Dizziness: feeling light‑headed, especially after standing.
  • Headache: mild to moderate intensity.
  • Cough: dry, non‑productive cough.
  • Peripheral edema: swelling of ankles or feet.
  • Flushing: transient warmth and redness of the skin.
  • Fatigue: general tiredness.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat that may impair breathing.
  • Severe hypotension: markedly low blood pressure causing faintness.
  • Liver dysfunction: abnormal liver enzyme elevations.
  • Neutropenia: reduced white blood cell count increasing infection risk.
  • Myocardial infarction: rare occurrence of heart attack.
  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.

Precautions & Warnings

Before prescribing Lercaton Plus, clinicians should consider several safety measures.

  • Blood pressure monitoring: check regularly to avoid excessive hypotension.
  • Renal function assessment: evaluate kidney status prior to initiation.
  • ACE inhibitor intolerance: avoid in patients with known hypersensitivity.
  • Hepatic impairment: use caution in patients with liver disease.
  • Concomitant potassium‑sparing agents: monitor serum potassium levels.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lercaton Plus may interact with other medicines, requiring attention to potential effects.

Major Interactions (Avoid)

  • Aliskiren in diabetic patients: combined use can increase risk of renal impairment.
  • Potassium supplements or potassium‑sparing diuretics: may cause hyperkalaemia.
  • NSAIDs: can blunt antihypertensive efficacy.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive effect.
  • Lithium: concurrent use can raise lithium concentrations.
  • Beta‑blockers: may mask tachycardia signs of hypotension.

Frequently Asked Questions

Lercaton Plus is prescribed to lower high blood pressure (hypertension) by combining an ACE inhibitor with a calcium‑channel blocker, providing a dual mechanism to achieve better blood‑pressure control in adult patients.

Enalapril blocks the conversion of angiotensin I to angiotensin II, reducing vasoconstriction, while lercanidipine blocks L‑type calcium channels in vascular smooth muscle, causing vasodilation. Together they lower peripheral resistance and blood pressure.

The dose of Lercaton Plus is individualized by the prescribing clinician based on the patient’s blood‑pressure level, response, and overall health status. No fixed regimen is provided here.

Safety of Lercaton Plus in pregnancy or lactation has not been fully established. Physicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapies, Lercaton Plus offers a combined ACE‑inhibitor and calcium‑channel blocker effect, which can improve blood‑pressure control and may reduce the need for multiple separate pills. It is generally considered when monotherapy does not achieve target pressures.

Lercaton Plus tablets should be stored at ambient temperature below 25 °C, kept in the original packaging, and protected from moisture and direct sunlight to maintain stability.

Lercaton Plus is taken orally, usually once daily, with or without food as directed by the prescribing healthcare professional.

Serious risks include angioedema, severe hypotension, liver dysfunction, neutropenia, myocardial infarction, and anaphylactic reactions. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, chest pain, or signs of an allergic reaction.

Lercaton Plus should be avoided in individuals with known hypersensitivity to ACE inhibitors or calcium‑channel blockers, a history of angioedema, severe renal or hepatic impairment, and in patients taking contraindicated medications such as aliskiren in diabetes.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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