Product image of Lergigan (Promethazine Hydrochloride) supplied by GNH India

Lergigan

Active Ingredient:
Promethazine Hydrochloride
Origin:
EU

Lergigan (Promethazine Hydrochloride)

Promethazine Hydrochloride, the active ingredient in Lergigan, is a first‑generation H1 antihistamine presented as an oral dosage form for oral use. It is employed to relieve allergic symptoms, prevent motion‑induced nausea, and provide sedation before surgical procedures in both adult and pediatric populations where appropriate.

GNH India supplies Lergigan as a licensed, GDP‑compliant international pharmaceutical supplier, delivering the product through regulated distribution channels to hospitals, pharmacies, and clinics worldwide, ensuring quality assurance and adherence to global regulatory standards and are widely used.

Manufacturer / TM Owner

Viatris Ab

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Indications & Clinical Uses

  • Promethazine Hydrochloride acts on histamine H1 receptors and is used for several allergic and nausea‑related conditions.
  • Allergic rhinitis: relief of nasal congestion, itching, sneezing, and watery eyes.
  • Urticaria: reduction of hives and associated itching.
  • Motion sickness: prevention and treatment of nausea, vomiting, and dizziness caused by travel.
  • Pre‑operative sedation: calming anxiety and providing sedation before surgical procedures.

How It Works

  • Promethazine Hydrochloride works by competitively blocking histamine H1 receptors in peripheral tissues and the central nervous system, reducing the actions of endogenous histamine that cause allergic symptoms. It also exhibits anticholinergic activity by inhibiting muscarinic receptors and modest dopamine D2 antagonism, contributing to its anti‑emetic and sedative properties. These combined effects dampen vestibular input and decrease the chemoreceptor trigger zone response, further preventing nausea.

Side Effects

Promethazine Hydrochloride may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Blurred vision
  • Constipation
  • Dizziness

Serious or Rare Side Effects

  • Severe allergic reactions (anaphylaxis)
  • Blood dyscrasias such as agranulocytosis
  • Seizures
  • Cardiac arrhythmias

Precautions & Warnings

  • When prescribing Promethazine Hydrochloride, several precautions should be observed to ensure patient safety.
  • Pregnancy: Use only if potential benefit justifies the potential risk to the fetus.
  • Elderly: Increased sensitivity to sedation and anticholinergic effects; dose may require adjustment.
  • Operating machinery: Avoid driving or operating heavy equipment due to possible drowsiness.
  • Concurrent CNS depressants: May potentiate sedation and respiratory depression.
  • Store at room temperature: Keep in the original container, protect from moisture and light.

Avoid Interactions

Promethazine Hydrochloride can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Alcohol: additive central nervous system depression leading to profound sedation.
  • Opioids: enhanced respiratory depression and sedation.
  • Benzodiazepines or barbiturates: increased sedative effect and risk of respiratory compromise.
  • Anticholinergic drugs: cumulative anticholinergic burden may cause severe dry mouth, urinary retention, or confusion.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: possible additive hypotensive effect.
  • Tricyclic antidepressants: increased anticholinergic side effects.
  • Theophylline: promethazine may raise plasma theophylline concentrations.

Frequently Asked Questions

Lergigan contains promethazine hydrochloride and is prescribed to relieve symptoms of allergic reactions such as rhinitis and urticaria, to prevent and treat motion‑induced nausea and vomiting, and to provide sedation or anxiety relief before surgical or diagnostic procedures.

Promethazine hydrochloride blocks histamine H1 receptors, reducing the effects of endogenous histamine that cause itching, swelling, and vasodilation. Its anticholinergic and dopamine‑blocking activities also suppress the vomiting centre and produce a calming, sedative effect.

The dose of Lergigan is individualized by the prescribing clinician based on the patient’s age, weight, medical condition, and response to therapy. Only a qualified health‑care professional should determine the appropriate regimen.

Promethazine is classified as a pregnancy‑category drug that should be used only when the potential benefit outweighs any risk to the fetus. It is excreted in breast milk, so breastfeeding mothers should discuss alternatives with their health‑care provider.

To request Lergigan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with second‑generation H1 antihistamines, promethazine offers stronger sedative and anti‑emetic effects but is more likely to cause drowsiness and anticholinergic side effects. It is often chosen when both allergy relief and nausea control are needed, whereas newer agents are preferred for non‑sedating allergy treatment.

Lergigan should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Lergigan is taken by mouth as directed by a health‑care professional. The tablet should be swallowed whole with water and can be taken with or without food, unless the prescriber advises otherwise.

Serious adverse events include severe allergic reactions such as anaphylaxis, blood disorders like agranulocytosis, seizures, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience symptoms such as difficulty breathing, rash, fever, or irregular heartbeat.

Lergigan is contraindicated in individuals with known hypersensitivity to promethazine or other phenothiazines, in patients with severe respiratory depression, and in newborns or infants under two months of age. Caution is also advised for those with glaucoma, urinary retention, or significant liver disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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