Product image of Lerkanidipin Actavis (Lercanidipine Hydrochloride) supplied by GNH India

Lerkanidipin Actavis

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lerkanidipin Actavis (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lerkanidipin Actavis, is a calcium channel blocker presented as an oral tablet for oral use. It is prescribed to lower elevated blood pressure in adult patients with hypertension.
GNH India supplies Lerkanidipin Actavis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Actavis Group Ptc Ehf.

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Indications & Clinical Uses

Lerkanidipin Actavis is a calcium channel blocker used in the management of high blood pressure.

  • Hypertension: reduces systolic and diastolic blood pressure, helping to prevent cardiovascular complications in adults.

How It Works

  • Lercanidipine selectively blocks L‑type calcium channels in vascular smooth muscle, inhibiting calcium influx. This causes relaxation of arterial smooth muscle, leading to vasodilation, decreased peripheral vascular resistance, and ultimately a reduction in systemic blood pressure.

Side Effects

Lercanidipine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Flushing: transient warmth and redness of the skin.
  • Peripheral edema: swelling of ankles or feet.
  • Dizziness or light‑headedness, especially after standing.
  • Tachycardia or palpitations.
  • Gastrointestinal discomfort such as nausea.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Myocardial infarction or acute coronary syndrome.
  • Hepatic enzyme elevation or liver injury.
  • Severe allergic reactions including rash or bronchospasm.
  • Cardiac arrhythmias requiring medical attention.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential risks.

  • Blood pressure monitoring: check regularly to ensure therapeutic response.
  • Hepatic function: assess liver enzymes in patients with known liver disease.
  • Elderly patients: start at the lowest dose and monitor for orthostatic effects.
  • Concomitant antihypertensives: adjust doses to avoid excessive hypotension.
  • Discontinuation: do not stop abruptly without medical guidance.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lercanidipine can interact with several drug classes, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase plasma levels.
  • Grapefruit juice: can markedly raise drug concentration.
  • Other calcium channel blockers: additive vasodilatory effect leading to hypotension.

Moderate Interactions (Monitor Closely):\n- Diuretics: may enhance blood‑pressure lowering effect.

  • ACE inhibitors or ARBs: combined therapy may require dose adjustments.
  • Beta‑blockers: monitor for bradycardia or excessive blood‑pressure reduction.
  • NSAIDs: may blunt antihypertensive response.
  • Simvastatin: increased risk of statin‑related muscle toxicity.

Frequently Asked Questions

Lerkanidipin Actavis contains lercanidipine, a calcium channel blocker indicated for the treatment of hypertension. By lowering elevated blood pressure, it helps reduce the risk of cardiovascular events such as stroke and heart attack in adult patients.

Lercanidipine selectively inhibits L‑type calcium channels in the smooth muscle of arterial walls. This blockade prevents calcium entry, causing the vessels to relax and dilate, which decreases peripheral resistance and lowers systemic blood pressure.

The appropriate dose of Lerkanidipin Actavis is determined by the prescribing healthcare professional based on the individual’s blood‑pressure profile, age, renal and hepatic function, and concomitant medications. Patients should follow the prescriber’s instructions exactly.

Safety data for lercanidipine in pregnancy and lactation are limited, and the product is generally not recommended unless the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both lercanidipine and amlodipine belong to the dihydropyridine class of calcium channel blockers and lower blood pressure by vasodilation. Lercanidipine has a longer half‑life and may provide smoother blood‑pressure control with a lower incidence of reflex tachycardia, but individual response varies.

Lerkanidipin Actavis tablets should be stored at temperatures below 25 °C in their original blister pack, protected from moisture and direct sunlight. Do not store in bathrooms or near heat sources, and keep out of reach of children.

The medication is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water. Patients should not crush, chew, or split the tablet unless specifically instructed by a healthcare professional.

Serious adverse events, although rare, include angioedema, severe hypotension, myocardial infarction, and significant liver enzyme elevations. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden fainting, chest pain, or jaundice.

Lerkanidipin Actavis is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation, and in those with severe aortic stenosis or unstable angina. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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