Product image of Lerkanidipin Zentiva (Lercanidipine Hydrochloride) supplied by GNH India

Lerkanidipin Zentiva

Active Ingredient:
Lercanidipine Hydrochloride
Origin:
EU

Lerkanidipin Zentiva (Lercanidipine Hydrochloride)

Lercanidipine, the active ingredient in Lerkanidipin Zentiva, is a calcium channel blocker presented as an oral tablet for oral use. It is employed to lower elevated blood pressure in adult patients with hypertension, helping to reduce cardiovascular risk.

GNH India supplies Lerkanidipin Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier, providing quality‑assured medication to hospitals, pharmacies and clinics worldwide. Our distribution network adheres to global standards, facilitating reliable access across multiple regions.

Manufacturer / TM Owner

Zentiva, K.S.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Lercanidipine is a calcium channel blocker used in the management of hypertension.
  • Hypertension: reduction of systolic and diastolic blood pressure, improving cardiovascular outcomes.

How It Works

  • Lercanidipine selectively inhibits L-type calcium channels in vascular smooth muscle, preventing calcium influx. This leads to relaxation of arterial smooth muscle, vasodilation, and a consequent decrease in peripheral vascular resistance, which lowers systemic blood pressure.

Side Effects

Lercanidipine may cause several adverse reactions that vary in frequency and severity.

Common Side Effects

  • Headache: mild to moderate pain often occurring shortly after dosing.
  • Flushing: transient warmth and redness of the skin, especially on the face.
  • Peripheral edema: swelling of the lower limbs due to fluid accumulation.
  • Dizziness: sensation of light‑headedness, particularly when standing quickly.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure that can cause fainting.
  • Angioedema: rapid swelling of the face, lips, tongue, or throat, potentially compromising airway.
  • Hepatotoxicity: rare liver injury manifested by elevated enzymes or jaundice.

Precautions & Warnings

  • When prescribing or dispensing Lercanidipine, several safety considerations should be observed.
  • Monitor blood pressure: adjust therapy based on regular measurements.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent rebound hypertension.
  • Caution in hepatic impairment: dose may need adjustment due to metabolism reliance on the liver.
  • Use with caution in elderly patients: increased sensitivity to vasodilatory effects.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Lercanidipine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma levels leading to excessive hypotension.
  • Co‑administration with other antihypertensives (e.g., ACE inhibitors, beta‑blockers): may cause additive blood‑pressure lowering.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampicin) may reduce drug exposure and effectiveness.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs) may blunt the antihypertensive response.
  • Grapefruit juice may increase systemic exposure, requiring careful monitoring.

Frequently Asked Questions

Lerkanidipin Zentiva contains lercanidipine hydrochloride, a calcium channel blocker indicated for the treatment of hypertension. It helps lower elevated blood pressure by relaxing arterial smooth muscle, thereby reducing cardiovascular risk in adult patients.

Lercanidipine selectively blocks L‑type calcium channels in vascular smooth muscle. By inhibiting calcium entry, it causes vasodilation, decreases peripheral vascular resistance, and ultimately reduces systemic blood pressure.

The dosage of Lerkanidipin Zentiva is determined by the prescribing healthcare professional based on the patient’s clinical condition, response, and any comorbidities. The prescriber will set the appropriate strength and frequency.

Safety data for lercanidipine in pregnancy and lactation are limited, and the product is generally not recommended for use unless the potential benefit justifies the potential risk. Physicians should evaluate each case individually.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lercanidipine belongs to the dihydropyridine class of calcium channel blockers, offering potent vasodilatory effects with a relatively favorable side‑effect profile compared with some older agents. It is often considered when patients need effective blood‑pressure control with once‑daily dosing.

Lerkanidipin Zentiva tablets should be stored at ambient temperature below 25 °C, in the original packaging, and protected from moisture and direct sunlight to maintain product stability.

The medication is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious adverse events, though rare, include severe hypotension, angioedema, and hepatic injury. Patients should be advised to seek immediate medical attention if they experience sudden dizziness, swelling of the face or throat, or signs of liver dysfunction such as jaundice.

Lerkanidipin Zentiva is contraindicated in patients with known hypersensitivity to lercanidipine or any component of the formulation, and it should be used with caution in individuals with severe hepatic impairment or unstable angina. A healthcare professional should assess suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Lercanidipine Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT