Product image of Lesamor (Hydrochlorothiazide, Telmisartan) supplied by GNH India

Lesamor

Active Ingredient:
Hydrochlorothiazide, Telmisartan
Origin:
EU

Lesamor (Hydrochlorothiazide, Telmisartan)

Hydrochlorothiazide / Telmisartan, the active ingredient in Lesamor, is a thiazide diuretic and angiotensin II receptor blocker presented as a tablet for oral use. It is prescribed to manage hypertension in adult patients, often when monotherapy is insufficient and to improve blood pressure control.

GNH India supplies Lesamor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to strict quality standards and provides regulatory documentation for each batch. Customers benefit from reliable logistics, competitive pricing, and responsive technical support.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Lesamor, a combination of a thiazide diuretic and an angiotensin II receptor blocker, is indicated for the treatment of hypertension.

  • Essential hypertension: lowers systolic and diastolic blood pressure to target levels.
  • Hypertension in patients with diabetes: improves blood pressure control and may provide renal protective benefits.
  • Hypertension resistant to monotherapy: offers additive antihypertensive effect when combined therapy is required.

How It Works

  • Telmisartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone-mediated sodium retention. Hydrochlorothiazide inhibits NaCl reabsorption in the distal convoluted tubule, promoting urinary excretion of sodium and water. The combined actions reduce plasma volume and systemic vascular resistance, resulting in lowered arterial pressure.

Side Effects

Common Side Effects

  • Dizziness: may occur due to reduced blood pressure.
  • Increased urination: result of the diuretic component.
  • Electrolyte imbalance (low potassium): caused by enhanced sodium excretion.

Serious or Rare Side Effects

  • Severe dehydration: can lead to hypotension and renal impairment.
  • Hyperkalemia or severe hypokalemia: significant electrolyte disturbances.
  • Angioedema: swelling of face, lips, or airway requiring immediate medical attention.
  • Hepatic dysfunction: abnormal liver enzymes or jaundice.
  • Renal impairment: worsening kidney function, especially in patients with pre‑existing disease.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor blood pressure: adjust dosage based on therapeutic response.
  • Assess renal function: check serum creatinine and eGFR prior to and during treatment.
  • Check electrolytes: especially potassium and sodium levels.
  • Avoid use in pregnancy: category D, potential fetal harm.
  • Caution in elderly patients: increased risk of volume depletion and orthostatic hypotension.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Lesamor may interact with several medicines; review patient medication lists carefully.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: risk of hyperkalemia.
  • Lithium: increased lithium concentrations and toxicity.
  • NSAIDs: may blunt antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: additive risk of renal dysfunction and hyperkalemia.
  • Other antihypertensives: potential for excessive hypotension.
  • Cyclosporine: may elevate serum creatinine and reduce drug clearance.

Frequently Asked Questions

Lesamor is a prescription medication that combines hydrochlorothiazide and telmisartan to treat high blood pressure (hypertension) in adult patients. The combination helps lower both systolic and diastolic pressures, especially when a single agent does not achieve target control.

Telmisartan blocks angiotensin II type 1 receptors, reducing vasoconstriction and aldosterone release, while hydrochlorothiazide inhibits sodium‑chloride reabsorption in the distal tubule, increasing urinary excretion of water and electrolytes. Together they decrease vascular resistance and plasma volume, lowering blood pressure.

The specific dose of Lesamor is determined by the prescribing clinician based on the patient’s blood pressure, renal function, and overall health status. Dosage adjustments are made according to therapeutic response and tolerability.

Lesamor is classified as pregnancy category D, indicating evidence of risk to the fetus, and it should be avoided during pregnancy unless clearly needed. Safety during breastfeeding has not been established, so it is generally not recommended without medical supervision.

To order Lesamor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑agent therapies, Lesamor offers the convenience of two mechanisms in one tablet, often providing better blood pressure control than either component alone. It may be preferred over other combination products when a thiazide‑diuretic plus an ARB is clinically appropriate.

Lesamor tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Protect them from moisture, direct sunlight, and excessive heat to maintain potency and stability.

Lesamor is taken orally, usually once daily, with or without food, as directed by the prescribing healthcare professional. Swallow the tablet whole with a full glass of water; do not crush or split unless instructed.

Serious risks include severe dehydration, electrolyte disturbances such as hyper‑ or hypokalemia, acute kidney injury, angioedema, and marked hypotension. Patients should seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, or signs of renal failure.

Lesamor should not be used by individuals with known hypersensitivity to hydrochlorothiazide, telmisartan, or any component of the formulation. It is also contraindicated in patients with severe renal impairment, anuria, or in women who are pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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