Product image of Lescol (Fluvastatin Sodium) supplied by GNH India

Lescol

Active Ingredient:
Fluvastatin Sodium
Origin:
EU

Lescol (Fluvastatin Sodium)

Fluvastatin, the active ingredient in Lescol, is a statin (HMG‑CoA reductase inhibitor) presented as an oral tablet for oral use. It lowers elevated cholesterol levels and is prescribed for patients with hypercholesterolemia or at risk of cardiovascular disease.

GNH India supplies Lescol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution. Clients benefit from comprehensive regulatory support and timely delivery across multiple regions efficiently.

Manufacturer / TM Owner

Ethyx Pharmaceuticals

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Indications & Clinical Uses

Lescol (fluvastatin) is used to manage disorders of lipid metabolism and reduce cardiovascular risk.

  • Hypercholesterolemia: reduces low‑density lipoprotein (LDL) cholesterol levels.
  • Hyperlipidemia: lowers total cholesterol and triglycerides.
  • Cardiovascular risk reduction: helps prevent myocardial infarction and stroke in patients with elevated cholesterol.

How It Works

  • Fluvastatin inhibits HMG‑CoA reductase, the key enzyme that catalyzes the conversion of HMG‑CoA to mevalonate, a precursor in cholesterol biosynthesis. By blocking this rate‑limiting step, hepatic synthesis of cholesterol declines, leading to up‑regulation of LDL receptors and increased clearance of circulating LDL particles, thereby lowering plasma cholesterol concentrations.

Side Effects

Fluvastatin may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache: mild to moderate pain in the head.
  • Muscle pain: soreness or weakness in skeletal muscles.
  • Elevated liver enzymes: mild increase in ALT or AST.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with risk of kidney injury.
  • Hepatotoxicity: significant elevation of liver enzymes or hepatitis.
  • Severe allergic reaction: rash, angioedema or anaphylaxis.

Precautions & Warnings

When prescribing fluvastatin, clinicians should consider several safety precautions.

  • Liver function monitoring: assess hepatic enzymes before initiation and periodically during therapy.
  • Muscle toxicity vigilance: discontinue if unexplained muscle pain, tenderness or weakness occurs.
  • Drug interactions review: avoid concomitant use with strong CYP3A4 inhibitors.
  • Pregnancy contraindication: do not use in pregnant women due to fetal risk.
  • Renal impairment adjustment: evaluate kidney function and adjust dose if necessary.
  • Store at ambient temperature: keep tablets in original packaging, protect from moisture and light.

Avoid Interactions

Fluvastatin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): may cause dangerous increases in fluvastatin levels.
  • Gemfibrozil: combined use raises risk of muscle toxicity.
  • Cyclosporine: enhances statin exposure and myopathy risk.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin): fluvastatin may potentiate anticoagulant effect, monitor INR.
  • Digoxin: possible increase in serum digoxin concentrations.
  • Niacin: may increase risk of myopathy when used together.

Frequently Asked Questions

Lescol contains fluvastatin, a statin that is prescribed to lower elevated cholesterol levels, treat hypercholesterolemia and hyperlipidemia, and reduce the risk of cardiovascular events such as heart attack and stroke in patients with high cholesterol.

Fluvastatin works by inhibiting the enzyme HMG‑CoA reductase, which is essential for cholesterol synthesis in the liver. This inhibition reduces the production of cholesterol, increases the number of LDL receptors on liver cells, and enhances the removal of LDL cholesterol from the bloodstream.

The appropriate dose of Lescol is determined by the prescribing healthcare professional based on the patient’s cholesterol levels, overall cardiovascular risk, and individual tolerance. Dosage may be adjusted over time according to therapeutic response and laboratory monitoring.

Lescol is classified as pregnancy category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as safety has not been established and the drug may pass into breast milk.

To order Lescol, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lescol (fluvastatin) is generally considered a moderate‑potency statin with a relatively short half‑life. Compared with high‑intensity statins such as atorvastatin or rosuvastatin, fluvastatin may require higher doses to achieve similar LDL‑cholesterol reductions, but it has a lower risk of certain drug‑drug interactions.

Lescol tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Lescol is taken orally as a tablet, usually once daily. The tablet should be swallowed whole with a glass of water and can be taken with or without food, unless otherwise directed by the prescriber.

The most serious adverse reactions to Lescol include rhabdomyolysis (severe muscle breakdown that can lead to kidney failure), significant liver injury (hepatotoxicity), and severe allergic reactions such as anaphylaxis. Patients should report unexplained muscle pain, weakness, or jaundice promptly.

Lescol should not be used by individuals with active liver disease, unexplained persistent elevations of hepatic enzymes, pregnancy, or by those who are breastfeeding. It is also contraindicated in patients with known hypersensitivity to fluvastatin or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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