Product image of Lescol Mr (Fluvastatin Sodium) supplied by GNH India

Lescol Mr

Active Ingredient:
Fluvastatin Sodium
Origin:
EU

Lescol Mr (Fluvastatin Sodium)

Fluvastatin Sodium, the active ingredient in Lescol MR, is a HMG‑CoA reductase inhibitor presented as an oral tablet for oral use. It treats hypercholesterolemia, hyperlipidemia and helps prevent cardiovascular disease in adult patients.
GNH India supplies Lescol MR as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ethyx Pharmaceuticals

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Indications & Clinical Uses

Lescol MR, a statin that lowers blood lipids, is indicated for the following conditions:

  • Hypercholesterolemia: reduces low‑density lipoprotein (LDL) cholesterol levels.
  • Hyperlipidemia: lowers total cholesterol and triglyceride concentrations.
  • Prevention of cardiovascular disease: decreases the risk of myocardial infarction, stroke and related events.

How It Works

  • Fluvastatin sodium competitively inhibits HMG‑CoA reductase, the key enzyme in hepatic cholesterol biosynthesis. This inhibition reduces intracellular cholesterol synthesis, prompting up‑regulation of LDL receptors on hepatocyte surfaces and enhancing clearance of circulating LDL particles, thereby lowering plasma cholesterol levels.

Side Effects

Common Side Effects

  • Headache: mild to moderate pain in the head region.
  • Abdominal pain: discomfort or cramping in the stomach area.
  • Nausea: feeling of queasiness or urge to vomit.
  • Muscle pain (myalgia): soreness or aching in skeletal muscles.
  • Constipation: difficulty passing stools.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown that can lead to kidney injury.
  • Elevated liver enzymes: signs of hepatic injury requiring monitoring.
  • Severe allergic reactions: rash, swelling, or anaphylaxis.
  • Myopathy: significant muscle weakness with elevated creatine kinase.
  • Hepatitis: inflammation of the liver.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Monitor liver function: obtain baseline and periodic liver enzyme tests.
  • Assess muscle symptoms: report unexplained muscle pain or weakness promptly.
  • Evaluate renal function: adjust use in severe renal impairment.
  • Avoid in active liver disease: contraindicated in patients with ongoing hepatic injury.
  • Use caution in pregnancy: safety not established; weigh risks and benefits.
  • Store at ambient temperature: keep below 25°C, protect from moisture and keep in original packaging.

Avoid Interactions

Fluvastatin may interact with other medicines. Review the following:

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): may increase fluvastatin exposure.
  • Gemfibrozil: raises risk of myopathy and rhabdomyolysis.
  • Cyclosporine: elevates plasma concentrations of fluvastatin.

Moderate Interactions (Monitor Closely)

  • Antacids (e.g., aluminum hydroxide): can reduce fluvastatin absorption.
  • Warfarin: fluvastatin may enhance anticoagulant effect; monitor INR regularly.

Frequently Asked Questions

Lescol MR contains fluvastatin sodium, a statin indicated for the treatment of hypercholesterolemia and hyperlipidemia, and for reducing the risk of cardiovascular events in patients with elevated lipid levels.

Fluvastatin inhibits the hepatic enzyme HMG‑CoA reductase, the rate‑limiting step in cholesterol synthesis. This decreases cholesterol production, up‑regulates LDL receptors, and enhances removal of LDL from the bloodstream.

The dosage of Lescol MR is individualized by the prescribing healthcare professional based on the patient’s lipid profile, cardiovascular risk, and tolerability. The prescriber determines the appropriate strength and dosing schedule, which may be adjusted during therapy.

Safety of fluvastatin during pregnancy and lactation has not been established. It is generally contraindicated in pregnant women because of potential teratogenic effects, and breastfeeding is not recommended unless a physician determines that the benefits outweigh the risks.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lescol MR (fluvastatin) is a moderate‑intensity statin with a relatively short half‑life compared with agents such as atorvastatin or rosuvastatin. It may be preferred in patients who need modest LDL‑cholesterol reductions or who have experienced intolerance to higher‑potency statins, though individual response varies.

Lescol MR tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Lescol MR is taken orally, usually once daily in the evening, with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew the modified‑release formulation.

The most serious adverse reactions include rhabdomyolysis, severe liver injury, and hypersensitivity reactions such as Stevens‑Johnson syndrome. Patients should promptly report unexplained muscle pain, weakness, dark urine, or signs of liver dysfunction such as jaundice.

Lescol MR is contraindicated in patients with active liver disease, unexplained persistent elevations of serum transaminases, known hypersensitivity to fluvastatin or any excipients, and in women who are pregnant or may become pregnant without appropriate contraception. Caution is also advised in severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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