Product image of Lescol Prolib (Fluvastatin Sodium) supplied by GNH India

Lescol Prolib

Active Ingredient:
Fluvastatin Sodium
Origin:
EU

Lescol Prolib (Fluvastatin Sodium)

Fluvastatin, the active ingredient in Lescol Prolib, is a HMG‑CoA reductase inhibitor presented as an oral tablet for oral use. It lowers elevated cholesterol and triglyceride levels and is used in patients with hypercholesterolemia or other lipid disorders.

GNH India supplies Lescol Prolib as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ethyx Pharmaceuticals

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Indications & Clinical Uses

Lescol Prolib, a statin medication, acts on the cholesterol synthesis pathway to manage dyslipidaemia.

  • Hypercholesterolemia: reduces low‑density lipoprotein (LDL) cholesterol levels.
  • Hyperlipidemia: lowers total cholesterol and triglycerides.
  • Prevention of cardiovascular events: decreases the risk of myocardial infarction and stroke in patients with elevated LDL cholesterol.

How It Works

  • Fluvastatin selectively inhibits HMG‑CoA reductase, the rate‑limiting enzyme in hepatic cholesterol biosynthesis. This inhibition reduces intracellular cholesterol, prompting up‑regulation of LDL receptors on hepatocytes, which enhances clearance of circulating LDL particles and lowers plasma cholesterol concentrations.

Side Effects

Common Side Effects

  • Headache: mild to moderate intensity.
  • Muscle pain: aching or soreness without weakness.
  • Abdominal discomfort: occasional stomach upset.
  • Nausea: transient feeling of queasiness.

Serious or Rare Side Effects

  • Rhabdomyolysis: severe muscle breakdown with potential renal failure.
  • Severe liver injury: marked elevation of transaminases or hepatitis.
  • Allergic reactions: rash, pruritus, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Pregnancy: contraindicated due to potential fetal harm.
  • Liver disease: avoid or monitor hepatic function closely.
  • Renal impairment: dose adjustment may be required.
  • Drug interactions: review concomitant medications for statin‑related interactions.
  • Monitoring: periodic lipid profile and liver enzyme assessments are recommended.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Fluvastatin may interact with several medicines; careful assessment is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin): increase fluvastatin exposure.
  • Gemfibrozil: heightened risk of myopathy.
  • Co‑administration with other statins: risk of additive toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, requiring INR monitoring.
  • Niacin: potential for increased liver enzyme elevations.
  • Antihypertensives: possible additive blood‑pressure lowering effect.

Frequently Asked Questions

Lescol Prolib contains fluvastatin, a statin that is prescribed to lower elevated cholesterol and triglyceride levels in patients with hypercholesterolemia or hyperlipidemia, and to reduce the risk of cardiovascular events such as heart attack and stroke.

Fluvastatin inhibits the enzyme HMG‑CoA reductase, which is essential for cholesterol synthesis in the liver. By blocking this step, the drug lowers hepatic cholesterol production, leading to increased LDL‑receptor expression and enhanced removal of LDL cholesterol from the bloodstream.

The dosage of Lescol Prolib is individualized by a prescriber based on the patient’s lipid profile, cardiovascular risk, and tolerability. The prescribing clinician determines the appropriate strength and dosing schedule.

Lescol Prolib is contraindicated in pregnancy because statins can cause fetal harm. It is also not recommended while breastfeeding, as fluvastatin may be excreted in breast milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lescol Prolib (fluvastatin) is a moderate‑intensity statin with a relatively short half‑life, offering flexibility in dosing and a lower potential for drug‑drug interactions compared with some higher‑potency statins. Choice of statin depends on individual risk factors, target lipid levels and tolerance.

Lescol Prolib should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Lescol Prolib is taken orally, usually once daily, with or without food, as directed by the prescribing healthcare professional. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

The most serious risks include rhabdomyolysis (severe muscle breakdown), significant liver injury, and rare allergic reactions such as anaphylaxis. Patients should report unexplained muscle pain, weakness, dark urine, or signs of liver dysfunction promptly.

Lescol Prolib should not be used by individuals who are pregnant, have active liver disease, or have a known hypersensitivity to fluvastatin or any excipients in the formulation. It is also contraindicated in patients taking certain strong CYP3A4 inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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