Product image of Lestinora (Melatonin) supplied by GNH India

Lestinora

Active Ingredient:
Melatonin
Origin:
EU

Lestinora (Melatonin)

Melatonin, the active ingredient in Lestinora, is a melatonin receptor agonist presented as an oral formulation for oral use. It helps manage insomnia, sleep onset difficulties and jet lag in adults.

GNH India supplies Lestinora as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for healthcare providers across multiple regions. All batches are manufactured under GMP conditions and undergo full regulatory review before distribution. Customers benefit from competitive pricing and comprehensive technical support.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

  • Lestinora (melatonin) acts on melatonin receptors to regulate the sleep‑wake cycle, addressing several sleep‑related conditions.
  • Insomnia: improves sleep initiation and maintenance in individuals with difficulty falling or staying asleep.
  • Sleep onset difficulties: reduces the time required to fall asleep for people experiencing delayed sleep onset.
  • Jet lag: helps realign circadian rhythms after rapid travel across time zones.

How It Works

  • Melatonin binds to MT1 and MT2 receptors in the suprachiasmatic nucleus of the hypothalamus, mimicking the endogenous hormone released during darkness. Activation of these G‑protein‑coupled receptors modulates intracellular cyclic AMP levels, leading to a phase‑shift of the circadian clock and promotion of sleep onset. By reinforcing the physiological night signal, melatonin facilitates the transition to sleep without directly depressing central nervous system activity.

Side Effects

Melatonin is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Drowsiness or daytime sleepiness.
  • Headache.
  • Dizziness.
  • Nausea.

Serious or Rare Side Effects

  • Allergic reaction such as rash, itching, swelling, or difficulty breathing.
  • Mood changes, including depression or agitation, especially with high doses.

Precautions & Warnings

  • When considering melatonin therapy, several precautionary measures should be observed.
  • Assess underlying conditions: evaluate for sleep disorders, depression, or seizure disorders before use.
  • Review concomitant medications: check for interactions with anticoagulants, immunosuppressants, or CNS depressants.
  • Adjust dosing in the elderly: start with the lowest effective dose due to increased sensitivity.
  • Avoid use in children unless advised by a pediatric specialist.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Melatonin may interact with other medicines, requiring attention to avoid reduced efficacy or increased risk.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): may increase bleeding risk.
  • Immunosuppressants (e.g., cyclosporine): may alter drug levels.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): additive sedation.
  • Antidiabetic agents: possible effect on glucose control.
  • Hormonal contraceptives: may reduce effectiveness.

Frequently Asked Questions

Lestinora contains melatonin and is used to help manage sleep‑related conditions such as insomnia, difficulty falling asleep and jet lag. By supporting the body’s natural circadian rhythm, it can improve sleep onset and overall sleep quality in adults who experience these disturbances.

Melatonin works by binding to MT1 and MT2 receptors in the brain’s suprachiasmatic nucleus, the central regulator of the circadian clock. This activation signals darkness, helping to shift the internal rhythm and promote the transition from wakefulness to sleep without directly depressing the central nervous system.

The appropriate dose of Lestinora is determined by a qualified prescriber based on the individual’s age, condition severity, and response to therapy. Healthcare professionals will select the strength and dosing schedule that best fits the patient’s needs.

Safety data for melatonin use in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before starting Lestinora.

To order Lestinora, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike sedative‑hypnotics that act on GABA receptors, melatonin works by normalising the body’s circadian signalling. This mechanism generally results in fewer cognitive side effects and a lower risk of dependence, making it a preferred option for short‑term regulation of sleep timing.

Lestinora should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Lestinora is taken orally, usually shortly before the intended bedtime. The tablet or capsule is swallowed whole with a glass of water. Patients should follow the timing and dosage instructions provided by their prescriber for optimal effect.

Serious risks, although rare, include allergic reactions such as rash, swelling, or difficulty breathing, and mood alterations like depression or agitation. If any of these symptoms occur, the patient should seek immediate medical attention.

Lestinora is not recommended for individuals with known hypersensitivity to melatonin, for children unless specifically prescribed by a pediatric specialist, and for patients taking certain medications that may interact significantly, such as anticoagulants or immunosuppressants, without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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