Product image of Lethe (Drospirenone, Ethinylestradiol | Lactose Anhydrous) supplied by GNH India

Lethe

Active Ingredient:
Drospirenone, Ethinylestradiol | Lactose Anhydrous
Origin:
EU

Lethe (Drospirenone, Ethinylestradiol | Lactose Anhydrous)

Drospirenone/Ethinylestradiol, the active ingredient in Lethe, is a combined oral contraceptive presented as a tablet for oral use. It prevents pregnancy in women of reproductive age.

GNH India supplies Lethe as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Lethe is a combined oral contraceptive that acts on the hormonal regulation of the menstrual cycle to prevent pregnancy.

  • Contraception: prevents unintended pregnancy in women of child‑bearing potential.
  • Menstrual cycle regulation: helps achieve more predictable bleeding patterns.
  • Management of androgenic symptoms: may improve acne and hirsutism associated with hormonal imbalance.

How It Works

  • Drospirenone/Ethinylestradiol works by suppressing the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH), thereby inhibiting ovulation. It also thickens cervical mucus to impede sperm penetration and induces endometrial changes that reduce the likelihood of implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like.
  • Breast tenderness: transient swelling or discomfort.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or emotional lability.
  • Spotting or breakthrough bleeding: irregular vaginal bleeding.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism.
  • Stroke: ischemic or haemorrhagic events.
  • Myocardial infarction: heart attack risk.
  • Severe hypertension: marked increase in blood pressure.
  • Liver disorders: cholestatic jaundice or hepatic dysfunction.
  • Allergic reactions: anaphylaxis or severe skin rash.

Precautions & Warnings

Before prescribing Lethe, clinicians should evaluate individual risk factors and counsel patients on safe use.

  • Thrombotic risk assessment: avoid in women with a history of clotting disorders.
  • Smoking restriction: do not use in smokers over 35 years of age.
  • Hepatic function review: contraindicated in severe liver disease.
  • Blood pressure monitoring: may elevate systolic/diastolic readings.
  • Missed dose guidance: follow specific instructions for skipped tablets.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Lethe may interact with several medicines that alter its effectiveness or safety profile.

Major Interactions (Avoid)

  • Enzyme inducers (rifampin, carbamazepine, phenytoin): reduce contraceptive efficacy.
  • Antiretrovirals (efavirenz, nevirapine): lower hormone levels.
  • St. John’s wort: diminishes contraceptive effect.
  • Certain antibiotics (griseofulvin): may decrease hormone concentrations.
  • Anticoagulants (warfarin): unpredictable effect on coagulation.

Moderate Interactions (Monitor Closely)

  • Antifungals (ketoconazole, itraconazole): increase hormone exposure.
  • SSRIs (fluoxetine, sertraline): may raise bleeding risk.
  • Diuretics (spironolactone): additive potassium‑sparing effect.
  • NSAIDs (ibuprofen, naproxen): possible blood pressure elevation.
  • Herbal supplements (ginseng): potential reduction in contraceptive reliability.

Frequently Asked Questions

Lethe is a combined oral contraceptive containing drospirenone and ethinylestradiol. It is prescribed to prevent unintended pregnancy in women of reproductive age and may also help regulate menstrual cycles and manage certain androgen‑related skin conditions.

The two hormones work together to suppress the mid‑cycle surge of luteinising hormone and follicle‑stimulating hormone, which stops ovulation. They also thicken cervical mucus to block sperm entry and alter the endometrium, making implantation unlikely.

The dosing regimen for Lethe is determined by the prescribing healthcare professional. Typically, it is taken as one tablet daily at the same time each day, but the exact schedule should follow the prescriber’s instructions.

Lethe is classified as Pregnancy Category X, meaning it must not be used during pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as hormonal contraceptives may affect milk production and infant exposure.

To order Lethe, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lethe contains drospirenone, which has anti‑mineralocorticoid and anti‑androgenic properties, potentially offering benefits such as reduced water retention and improved acne compared with some other estrogen‑progestin combinations. Efficacy in preventing pregnancy is comparable across approved combined oral contraceptives.

Lethe tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and keep out of reach of children.

Lethe is taken orally as a tablet. Patients should swallow the tablet with water once daily, preferably at the same time each day, and follow the specific missed‑dose instructions provided by their healthcare professional.

Serious risks include venous thromboembolism, stroke, myocardial infarction, severe hypertension, and liver disorders. Women with a history of clotting disorders, smoking over 15 cigarettes per day, or certain cardiovascular conditions should avoid using Lethe.

Lethe is contraindicated in women who are pregnant, breastfeeding, have a history of thromboembolic disease, severe liver disease, uncontrolled hypertension, known or suspected estrogen‑dependent tumors, or who are smokers over 35 years of age.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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