Product image of Letizen (Cetirizine Dihydrochloride) supplied by GNH India

Letizen

Active Ingredient:
Cetirizine Dihydrochloride
Origin:
EU

Letizen (Cetirizine Dihydrochloride)

Cetirizine, the active ingredient in Letizen, is a second‑generation antihistamine presented as an oral tablet for systemic use. It alleviates symptoms of allergic rhinitis, chronic urticaria and allergic conjunctivitis in adults and children.

GNH India supplies Letizen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory support and consistent product quality across multiple markets. The company adheres to stringent quality standards, ensures traceability, and offers flexible logistics to meet the needs of healthcare providers in Europe, Asia and Africa.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Cetirizine is used to manage allergic conditions by blocking peripheral H1 receptors.
  • Allergic rhinitis: reduces nasal congestion, sneezing and itching.
  • Urticaria: relieves hives and associated itching.
  • Allergic conjunctivitis: diminishes eye redness, tearing and itching.

How It Works

  • Cetirizine acts as a selective antagonist of peripheral histamine H1 receptors. By competitively binding to these receptors, it prevents histamine released from mast cells and basophils from triggering the cascade that leads to vasodilation, increased vascular permeability and sensory nerve stimulation. The result is a reduction in the classic signs of allergy such as itching, swelling, rhinorrhea and conjunctival irritation, without significant sedation due to limited penetration of the blood‑brain barrier.

Side Effects

Cetirizine may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dry mouth: mild sensation of oral dryness.
  • Headache: transient mild headache.
  • Drowsiness: occasional mild somnolence, less frequent than first‑generation antihistamines.
  • Fatigue: feeling of reduced energy.
  • Nausea: mild stomach upset.

Serious or Rare Side Effects

  • Anaphylaxis: rare severe allergic reaction requiring immediate medical attention.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac arrhythmia: very rare reports of rhythm disturbances.
  • Hepatic dysfunction: uncommon elevation of liver enzymes.
  • Blood dyscrasias: rare cases of neutropenia or thrombocytopenia.

Precautions & Warnings

  • When prescribing cetirizine, consider the following precautions to ensure safe use.
  • Renal impairment: adjust dose in patients with severe kidney dysfunction.
  • Elderly patients: monitor for increased sedation or confusion.
  • Pregnancy and lactation: use only if clearly needed after risk‑benefit assessment.
  • Concomitant CNS depressants: avoid excessive drowsiness when combined with alcohol or sedatives.
  • Driving and machinery: caution if experiencing any degree of drowsiness.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original packaging.

Avoid Interactions

Cetirizine can interact with other medicines, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Ketoconazole or erythromycin: may increase cetirizine plasma levels, raising risk of side effects.
  • Theophylline: can reduce antihistamine effect, leading to inadequate symptom control.
  • Alcohol: additive CNS depression may cause marked drowsiness.

Moderate Interactions (Monitor Closely)

  • Ritonavir: may modestly raise cetirizine concentrations.
  • Cimetidine: can slightly increase cetirizine exposure.
  • Other antihistamines: combined use may enhance sedation.

Frequently Asked Questions

Letizen contains cetirizine, a second‑generation antihistamine indicated for the relief of symptoms associated with allergic rhinitis, chronic urticaria (hives) and allergic conjunctivitis. It helps reduce nasal congestion, itching, sneezing, eye irritation and skin rash caused by allergic reactions.

Cetirizine selectively blocks peripheral H1 histamine receptors. By preventing histamine from binding to these receptors, it stops the cascade that leads to vasodilation, increased vascular permeability and nerve stimulation, thereby reducing the typical signs of allergy such as itching, swelling and redness.

The appropriate dose of Letizen is determined by the prescribing healthcare professional based on the patient’s age, weight, renal function and the severity of the allergic condition. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for cetirizine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider after a careful risk‑benefit assessment.

To order Letizen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and assistance with import documentation.

Letizen (cetirizine) is a second‑generation antihistamine, offering effective allergy relief with a lower incidence of sedation compared with first‑generation agents such as diphenhydramine. Compared with other second‑generation drugs like loratadine, cetirizine may have a slightly faster onset of action, while still maintaining a favorable safety profile.

Letizen tablets should be stored at ambient temperature, preferably below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Letizen is taken orally, usually with a glass of water. It can be taken with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush, chew, or split it unless specifically instructed by a healthcare professional.

Although rare, serious adverse reactions may include anaphylaxis, severe skin reactions such as Stevens‑Johnson syndrome, cardiac arrhythmias, hepatic dysfunction, and blood dyscrasias. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, widespread rash, yellowing of the skin or eyes, or unexplained bruising or bleeding.

Letizen should be avoided in individuals with known hypersensitivity to cetirizine or any of its excipients. Caution is advised for patients with severe renal impairment, those taking interacting medications listed under major interactions, and pregnant or breastfeeding women unless the benefit outweighs the risk as assessed by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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