Product image of Letizen (Cetirizine Dihydrochloride) supplied by GNH India

Letizen

Active Ingredient:
Cetirizine Dihydrochloride
Origin:
EU

Letizen (Cetirizine Dihydrochloride)

Cetirizine dihydrochloride, the active ingredient in Letizen, is an H1‑receptor antagonist presented as an oral tablet for systemic use. It relieves the nasal and skin symptoms of allergic rhinitis, seasonal hay fever and chronic idiopathic urticaria in both adults and children.\n\nGNH India supplies Letizen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Letizen is an oral antihistamine that acts on the histamine‑mediated allergic pathway.\n\nAllergic rhinitis: reduces sneezing, nasal itching, and runny nose.\nSeasonal allergic rhinitis (hay fever): alleviates eye and nasal itching, congestion and watery discharge.\nChronic idiopathic urticaria: diminishes hives and associated itching.

How It Works

  • Cetirizine dihydrochloride selectively blocks peripheral H1 receptors, preventing histamine from binding to mast‑cell and basophil receptors. By inhibiting this interaction, it stops the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby reducing the classic signs of an allergic response.

Side Effects

  • Adverse reactions may occur with cetirizine use.\n\nCommon Side Effects:\n- Drowsiness\n- Dry mouth\n- Headache\n- Fatigue\n\nSerious or Rare Side Effects:\n- Anaphylactic reaction\n- Stevens‑Johnson syndrome\n- Angioedema

Precautions & Warnings

  • Before using Letizen, consider the following safety points.\n\nPregnancy: consult a healthcare professional; safety data are limited.\nBreastfeeding: use with caution; cetirizine may pass into milk.\nRenal impairment: dose adjustment may be required in reduced kidney function.\nElderly: monitor for increased sedation or confusion.\nDrug interactions: avoid concurrent use with other CNS depressants without medical advice.\nStore at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

  • Cetirizine can interact with several medicines; monitoring is advised.\n\nMajor Interactions (Avoid):\n- Alcohol: may increase sedation.\n- Other antihistamines: additive antihistaminic effect.\n- CNS depressants (e.g., benzodiazepines): enhanced drowsiness.\n\nModerate Interactions (Monitor Closely):\n- Theophylline: may raise plasma cetirizine levels.\n- Ritonavir: can increase cetirizine exposure.\n- Ketoconazole: may elevate cetirizine concentrations.

Frequently Asked Questions

Letizen contains cetirizine dihydrochloride and is used to relieve the symptoms of allergic rhinitis, seasonal hay fever and chronic idiopathic urticaria. It helps reduce sneezing, itching, runny nose, watery eyes and hives associated with these allergic conditions.

Cetirizine works by selectively blocking peripheral H1 histamine receptors. By preventing histamine from binding to these receptors, it stops the cascade that causes vasodilation, increased vascular permeability and nerve stimulation, which are responsible for typical allergy symptoms.

The exact dose of Letizen is determined by the prescribing clinician based on the patient’s age, weight and clinical condition. In most adult cases, a single 10 mg tablet taken once daily is common, but the prescriber may adjust the regimen as needed.

Safety data for cetirizine in pregnancy are limited, so Letizen should only be used if the potential benefit outweighs any risk and after consulting a healthcare professional. During breastfeeding, cetirizine can be excreted in milk; caution and medical advice are recommended.

To order Letizen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letizen (cetirizine) is a second‑generation antihistamine that offers effective allergy relief with a lower incidence of sedation compared with first‑generation agents such as diphenhydramine. Its once‑daily dosing and favorable safety profile make it a common choice for chronic allergic conditions.

Letizen tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Letizen is taken orally with or without food. The tablet should be swallowed whole with a glass of water. Patients should follow the dosing instructions provided by their healthcare professional and avoid crushing or chewing the tablet unless directed otherwise.

While rare, serious adverse reactions can include anaphylaxis, Stevens‑Johnson syndrome and angioedema. Any signs of severe allergic response—such as difficulty breathing, swelling of the face or throat, or widespread rash—require immediate medical attention.

Letizen should be avoided in individuals with known hypersensitivity to cetirizine or any other component of the formulation. Caution is also advised for patients with severe renal impairment, pregnant or breastfeeding women unless directed by a physician, and those taking interacting CNS depressants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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