Product image of Letizen (Cetirizine Dihydrochloride) supplied by GNH India

Letizen

Active Ingredient:
Cetirizine Dihydrochloride
Origin:
EU

Letizen (Cetirizine Dihydrochloride)

Cetirizine, the active ingredient in Letizen, is a second‑generation antihistamine presented as an oral tablet for oral use. It is used to relieve symptoms of allergic rhinitis and urticaria in both adults and children.

GNH India supplies Letizen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Letizen, a second‑generation antihistamine, acts on histamine‑mediated allergic conditions.
  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge.
  • Urticaria (hives): alleviates itching and diminishes wheal formation.

How It Works

  • Cetirizine selectively antagonizes peripheral histamine H1 receptors, preventing histamine from binding and activating these receptors. By blocking the H1‑mediated cascade, it reduces vascular permeability, sensory nerve stimulation, and smooth‑muscle contraction that underlie the symptoms of allergic reactions.

Side Effects

Cetirizine is generally well tolerated, but adverse reactions can occur.

Common Side Effects

  • Drowsiness: mild sedation may be experienced.
  • Headache: occasional tension‑type headache.
  • Dry mouth: reduced salivation.
  • Fatigue: feeling of tiredness.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction.
  • Angioedema: swelling of face, lips or tongue.
  • Anaphylaxis: rare systemic allergic reaction.

Precautions & Warnings

  • Before using Letizen, consider the following safety points.
  • Use in children: follow prescriber guidance for age‑appropriate dosing.
  • Concurrent CNS depressants: may increase sedation.
  • Liver impairment: dose adjustment may be required.
  • Pregnancy and breastfeeding: consult a healthcare professional.
  • Driving or operating machinery: caution due to possible drowsiness.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Cetirizine may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Alcohol: enhances sedative effect.
  • CNS depressants (e.g., benzodiazepines): may increase drowsiness.
  • Ritonavir: can raise cetirizine plasma levels.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may reduce absorption.
  • Strong CYP3A4 inhibitors (e.g., erythromycin): may modestly increase levels.
  • Digoxin: possible increase in serum concentration.

Frequently Asked Questions

Letizen contains cetirizine, a second‑generation antihistamine that is indicated for the relief of symptoms associated with allergic rhinitis, such as sneezing and nasal congestion, and for the treatment of urticaria (hives), where it helps reduce itching and the appearance of wheals.

Cetirizine works by selectively blocking peripheral histamine H1 receptors. By preventing histamine from binding to these receptors, it stops the cascade that leads to increased vascular permeability, nerve irritation, and smooth‑muscle contraction, thereby alleviating typical allergy symptoms.

The appropriate dose of Letizen is determined by a qualified prescriber based on the patient’s age, weight, renal function and the specific indication. Healthcare professionals tailor the regimen to achieve optimal symptom control while minimizing potential side effects.

Safety data for cetirizine in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the potential risks and benefits with their healthcare provider before starting Letizen.

To request Letizen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letizen (cetirizine) is a second‑generation antihistamine, offering effective allergy relief with a lower incidence of sedation compared with first‑generation agents such as diphenhydramine. Its once‑daily dosing and favorable safety profile make it a common choice for both seasonal and perennial allergic conditions.

Letizen should be stored at ambient temperature below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Letizen is taken orally, usually with a glass of water. It can be taken with or without food, as directed by the prescribing clinician. Swallow the tablet whole; do not crush or chew unless specifically instructed.

While rare, serious adverse reactions to Letizen can include severe skin reactions such as Stevens‑Johnson syndrome, angioedema (swelling of the face, lips or tongue), and anaphylaxis. Immediate medical attention is required if any of these symptoms develop.

Individuals with known hypersensitivity to cetirizine or any component of the formulation should not use Letizen. Caution is also advised for patients with severe hepatic impairment, and it should be used only under medical supervision in pregnant or nursing women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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