Product image of Letizen S (Cetirizine Dihydrochloride) supplied by GNH India

Letizen S

Active Ingredient:
Cetirizine Dihydrochloride
Origin:
EU

Letizen S (Cetirizine Dihydrochloride)

Cetirizine, the active ingredient in Letizen S, is a second‑generation H1 antihistamine presented as an oral tablet for oral use. It is used to relieve symptoms of allergic rhinitis, seasonal and perennial allergies, and chronic idiopathic urticaria in adults and children.

GNH India supplies Letizen S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka-Farma D.O.O.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Letizen S, a second‑generation H1 antihistamine, is indicated for several allergic and hypersensitivity conditions.
  • Allergic rhinitis: reduces sneezing, itching, and nasal discharge.
  • Seasonal allergic rhinitis: alleviates symptoms triggered by pollen or outdoor allergens.
  • Perennial allergic rhinitis: controls year‑round nasal allergy symptoms.
  • Chronic idiopathic urticaria: diminishes hives and associated itching.
  • Other hypersensitivity reactions: mitigates skin and mucosal allergic responses.

How It Works

  • Cetirizine dihydrochloride acts as a selective peripheral H1‑receptor antagonist. By binding to H1 receptors on mast cells and basophils, it blocks the action of histamine, preventing vasodilation and increased vascular permeability that cause typical allergic manifestations such as itching, swelling, and rhinorrhea.

Side Effects

Cetirizine is generally well tolerated, but some adverse reactions may occur.

Common Side Effects

  • Mild headache.
  • Drowsiness or fatigue (less frequent than first‑generation antihistamines).
  • Dry mouth.
  • Nausea or abdominal discomfort.
  • Dizziness.
  • Sore throat.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with rash, swelling, or difficulty breathing.
  • Cardiac arrhythmias in susceptible individuals.
  • Liver enzyme elevations.
  • Blood dyscrasias such as neutropenia.
  • Persistent tachycardia.
  • Severe skin reactions like Stevens‑Johnson syndrome.

Precautions & Warnings

  • Before using Letizen S, consider the following precautions.
  • Pregnancy: Category B; discuss use with a healthcare professional.
  • Breastfeeding: Small amounts may be excreted in milk; consult a physician.
  • Renal impairment: Dose adjustment may be required.
  • Elderly patients: Monitor for increased sedation.
  • Driving or operating machinery: Caution if experiencing drowsiness.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Cetirizine may interact with several medicines; awareness helps avoid adverse effects.

Major Interactions (Avoid)

  • Ketoconazole or erythromycin: may increase cetirizine plasma levels.
  • Theophylline: can reduce antihistamine efficacy.
  • Alcohol: additive CNS depression.

Moderate Interactions (Monitor Closely)

  • Other antihistamines: risk of additive sedation.
  • CNS depressants (benzodiazepines, opioids): may enhance drowsiness.
  • Rifampicin: may lower cetirizine concentrations.

Frequently Asked Questions

Letizen S contains cetirizine, which is indicated for relief of symptoms associated with allergic rhinitis, both seasonal and perennial, as well as chronic idiopathic urticaria and other hypersensitivity reactions. It helps reduce sneezing, itching, nasal discharge, and hives.

Cetirizine is a selective H1‑receptor antagonist. By blocking peripheral H1 receptors on mast cells and basophils, it prevents histamine from binding, thereby reducing vasodilation, increased vascular permeability, and the resulting allergic symptoms such as itching and swelling.

The appropriate dose of Letizen S is determined by a prescriber based on the patient’s age, condition, and clinical response. Healthcare professionals tailor the regimen to achieve optimal symptom control while minimizing potential side effects.

Cetirizine is classified as Pregnancy Category B, indicating no evidence of risk in animal studies, but human data are limited. It is excreted in small amounts in breast milk, so a healthcare provider should evaluate the benefit‑risk balance before use in pregnant or nursing women.

To place an order, submit an enquiry on the Letizen S product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Letizen S (cetirizine) is a second‑generation antihistamine offering effective allergy relief with a lower incidence of sedation compared with first‑generation agents like diphenhydramine. Compared with other second‑generation drugs such as loratadine, cetirizine may provide slightly faster onset of action for some patients.

Letizen S should be stored at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture, excessive heat, and direct sunlight to maintain stability and potency throughout the shelf life.

Letizen S is taken orally, usually with a glass of water. The tablet can be swallowed with or without food, unless the prescriber advises otherwise. Patients should follow the dosing instructions provided by their healthcare professional.

Serious but rare risks include anaphylactic reactions, severe skin reactions such as Stevens‑Johnson syndrome, and cardiac arrhythmias in susceptible individuals. Patients should seek immediate medical attention if they experience symptoms like difficulty breathing, rash, or irregular heartbeat.

Letizen S should be avoided in individuals with known hypersensitivity to cetirizine or any component of the formulation. Caution is also advised for patients with severe renal impairment, pregnant or nursing women without medical guidance, and those taking interacting medications without physician supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.