Product image of Letizen S (Cetirizine Dihydrochloride) supplied by GNH India

Letizen S

Active Ingredient:
Cetirizine Dihydrochloride
Origin:
EU

Letizen S (Cetirizine Dihydrochloride)

Cetirizine, the active ingredient in Letizen S, is a H1 receptor antagonist presented as an oral tablet for oral use. It relieves symptoms of allergic rhinitis and urticaria in adults and children when appropriate.
GNH India supplies Letizen S as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Letizen S, an antihistamine, acts on the histamine H1 pathway to control allergic conditions.
  • Allergic rhinitis: reduces nasal congestion, itching, sneezing and watery discharge.
  • Urticaria: alleviates itching and hives associated with chronic or acute hives.
  • Allergic conjunctivitis: helps diminish eye itching, redness and tearing.

How It Works

  • Cetirizine dihydrochloride selectively blocks peripheral histamine H1 receptors, preventing histamine from binding and activating the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation. By inhibiting this receptor, the drug diminishes the classic signs of allergic inflammation without crossing the blood‑brain barrier in significant amounts.

Side Effects

Common Side Effects

  • Drowsiness: mild to moderate sleepiness.
  • Fatigue: feeling of reduced energy.
  • Dry mouth: decreased salivation.
  • Headache: mild cranial pain.
  • Nausea: upset stomach.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical care.
  • Stevens‑Johnson syndrome: rare skin disorder with blistering.
  • Angioedema: swelling of face, lips or tongue.
  • Hepatotoxicity: abnormal liver function tests.

Precautions & Warnings

  • Before using Letizen S, consider the following precautions.
  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: use with caution; discuss with a physician.
  • Renal impairment: dose adjustment may be required.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Alcohol: avoid or limit intake to reduce drowsiness.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Cetirizine may interact with several medicines.

Major Interactions (Avoid)

  • Alcohol: may increase sedation.
  • CNS depressants (e.g., benzodiazepines, opioids): risk of excessive drowsiness.
  • Theophylline: may raise cetirizine plasma levels.

Moderate Interactions (Monitor Closely)

  • Ritonavir: can increase cetirizine exposure.
  • Antacids containing aluminum or magnesium: may reduce absorption.
  • Antihypertensives: possible additive hypotensive effect.

Frequently Asked Questions

Letizen S contains cetirizine, an antihistamine that is used to relieve the symptoms of allergic rhinitis, such as sneezing, runny nose and itchy eyes, as well as to control itching and hives associated with urticaria.

Cetirizine works by selectively blocking peripheral histamine H1 receptors. This prevents histamine released during an allergic response from binding to its receptors, thereby reducing vasodilation, increased permeability and nerve stimulation that cause typical allergy symptoms.

The appropriate dose of Letizen S is determined by a prescriber based on the patient’s age, weight, renal function and the severity of symptoms. Healthcare professionals follow local labeling recommendations when deciding the exact amount and frequency.

Safety data for cetirizine in pregnancy are limited, so pregnant women should only use Letizen S if the potential benefit outweighs any risk and after consulting their doctor. While small amounts are excreted in breast milk, nursing mothers should seek medical advice before use.

To order Letizen S, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letizen S (cetirizine) is a second‑generation antihistamine that generally causes less sedation than first‑generation agents such as diphenhydramine. Compared with another second‑generation option, loratadine, cetirizine may have a slightly faster onset of action but a similar safety profile.

Store Letizen S at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack or container, protect them from moisture and direct sunlight, and keep out of reach of children.

Letizen S is taken orally, usually with a glass of water. It can be taken with or without food, depending on the prescriber’s advice, and should be swallowed whole without crushing or chewing the tablet.

The most serious risks include rare allergic reactions such as anaphylaxis, severe skin conditions like Stevens‑Johnson syndrome, and angioedema that can affect breathing. Immediate medical attention is required if any of these symptoms appear.

Individuals with known hypersensitivity to cetirizine or any component of the formulation should avoid Letizen S. Caution is also advised for patients with severe renal impairment, and it should be used only under medical supervision in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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