Product image of Letrovena (Letrozole) supplied by GNH India

Letrovena

Active Ingredient:
Letrozole
Origin:
EU

Letrovena (Letrozole)

Letrozole, the active ingredient in Letrovena, is a aromatase inhibitor presented as a unknown/unknown for oral use. It treats hormone receptor‑positive breast cancer in postmenopausal women.
GNH India supplies Letrovena as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Vipharm S.A.

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Indications & Clinical Uses

Letrovena, an aromatase inhibitor, is employed in the management of estrogen‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer (adjuvant): Reduces risk of recurrence after surgery.
  • Hormone receptor‑positive breast cancer (metastatic): Helps control disease progression.
  • Estrogen‑dependent breast cancer (postmenopausal): Lowers estrogen levels to inhibit tumor growth.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, a non‑steroidal blockade that prevents the peripheral conversion of androgens to estrogens. By reducing circulating estrogen concentrations, it deprives estrogen‑responsive tumor cells of a growth stimulus, thereby slowing or halting the progression of hormone‑sensitive breast cancer.

Side Effects

Letrovena may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Hot flashes: sudden feeling of warmth, often with sweating.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.
  • Arthralgia: joint pain or stiffness.
  • Headache: pressure or throbbing sensation.
  • Increased sweating: excessive perspiration.

Serious or Rare Side Effects

  • Bone fracture: increased risk due to reduced estrogen.
  • Deep vein thrombosis or pulmonary embolism: blood clot formation.
  • Severe liver dysfunction: elevated enzymes or hepatitis.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • QT interval prolongation: potential cardiac rhythm disturbance.
  • Severe osteoporosis: marked loss of bone density.

Precautions & Warnings

Before initiating Letrovena, several safety considerations should be reviewed.

  • Monitor bone health: assess bone mineral density periodically.
  • Evaluate liver function: conduct baseline and periodic liver enzyme tests.
  • Assess cardiovascular risk: watch for signs of thrombosis.
  • Review concomitant medications: avoid known major interactions.
  • Counsel on menopausal symptoms: discuss management of hot flashes and sweating.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Letrovena can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Tamoxifen: concurrent use may reduce therapeutic effect of letrozole.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may lower letrozole plasma concentrations.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.

Moderate Interactions (Monitor Closely)

  • SSRIs (e.g., fluoxetine, paroxetine): may raise letrozole levels.
  • Diabetes medications (e.g., metformin, insulin): monitor glucose control as hormonal changes can affect metabolism.

Frequently Asked Questions

Letrovena contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used in both adjuvant settings after surgery and in metastatic disease to reduce estrogen‑driven tumor growth.

Letrozole blocks the aromatase enzyme, which converts adrenal and peripheral androgens into estrogens. By inhibiting this conversion, circulating estrogen levels fall, depriving estrogen‑dependent breast cancer cells of a key growth signal and thereby slowing tumor progression.

The exact dosage of Letrovena is determined by the prescribing clinician based on the patient’s clinical status, renal and hepatic function, and treatment goals. Typical regimens involve a once‑daily oral tablet, but the prescriber sets the final dose and schedule.

Letrovena is contraindicated in pregnancy and is not recommended for breastfeeding women because it can affect estrogen levels essential for fetal development and milk production. Women of child‑bearing potential should use effective contraception during treatment.

To order Letrovena, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Letrovena (letrozole) belongs to the non‑steroidal aromatase inhibitor class, similar to anastrozole. Compared with steroidal inhibitors such as exemestane, letrozole generally offers a longer half‑life and may provide slightly higher estrogen suppression, though clinical outcomes are comparable and choice often depends on tolerability and physician preference.

Letrovena tablets should be stored at ambient temperature below 25 °C, in the original container, protected from moisture and direct light. Keep out of reach of children and do not use if the packaging is damaged or the tablets appear discoloured.

Letrovena is taken orally, usually once daily, with a full glass of water. It can be taken with or without food, but consistent administration with respect to meals helps maintain stable drug levels. Swallow tablets whole; do not crush or chew them.

Serious risks include bone fractures due to decreased estrogen, deep‑vein thrombosis or pulmonary embolism, severe liver injury, and rare allergic reactions such as anaphylaxis. Patients should report sudden joint pain, swelling, shortness of breath, jaundice, or rash to their healthcare provider promptly.

Letrovena should not be used in premenopausal women, individuals with known hypersensitivity to letrozole or any component of the formulation, and patients with severe hepatic impairment. Caution is also advised for those with uncontrolled cardiovascular disease or a history of thromboembolic events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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