Product image of Letrox (Levothyroxine Sodium, Hydrate) supplied by GNH India

Letrox

Active Ingredient:
Levothyroxine Sodium, Hydrate
Origin:
EU

Letrox (Levothyroxine Sodium, Hydrate)

Levothyroxine sodium, the active ingredient in Letrox, is a synthetic thyroid hormone presented as an oral tablet for oral use. It replaces deficient endogenous thyroxine (T4) and is indicated for the long‑term management of hypothyroidism, goitre, thyroid hormone replacement after thyroidectomy, and congenital hypothyroidism in both adults and pediatric patients.

GNH India supplies Letrox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Letrox (levothyroxine sodium) is used to treat conditions related to thyroid hormone deficiency.

  • Hypothyroidism: restores normal thyroid hormone levels and alleviates symptoms such as fatigue and weight gain.
  • Goitre: reduces thyroid gland enlargement by normalising hormone feedback.
  • Post‑thyroidectomy replacement: provides necessary T4 after surgical removal of the thyroid.
  • Congenital hypothyroidism: ensures adequate hormone for growth and neurodevelopment in infants.

How It Works

  • Levothyroxine sodium is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it is converted to the active triiodothyronine (T3) within target tissues. Both T4 and T3 bind nuclear thyroid hormone receptors, modulating gene transcription that regulates basal metabolic rate, protein synthesis, and growth. By restoring circulating thyroid hormone concentrations, the drug normalises metabolic activity across multiple organ systems.

Side Effects

Levothyroxine may cause a range of adverse reactions. Most are mild and dose‑related, while rare events can be serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Insomnia: difficulty falling or staying asleep.
  • Palpitations: sensation of rapid or irregular heartbeat.
  • Heat intolerance: increased sensitivity to warm environments.
  • Weight loss: unintended reduction in body weight.
  • Tremor: fine shaking of the hands.

Serious or Rare Side Effects

  • Cardiac arrhythmia: abnormal heart rhythm that may require medical attention.
  • Angina or myocardial infarction: chest pain or heart attack in susceptible individuals.
  • Severe hyperthyroidism: symptoms such as extreme weight loss, agitation, and fever.
  • Osteoporosis or bone loss: reduced bone mineral density with long‑term overtreatment.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Acute adrenal crisis: precipitated in patients with untreated adrenal insufficiency.

Precautions & Warnings

When prescribing or using Letrox, several safety considerations are recommended.

  • Dose titration: adjust the dose based on regular TSH and free T4 monitoring.
  • Cardiovascular disease: monitor heart rate and rhythm, especially in patients with ischemic heart disease.
  • Pregnancy: use only if the expected benefit outweighs potential risks to the fetus.
  • Elderly patients: initiate therapy at a lower dose and increase cautiously.
  • Drug interactions: review concomitant medications that may affect levothyroxine absorption or metabolism.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levothyroxine can interact with several medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Calcium supplements: reduce levothyroxine absorption when taken concurrently.
  • Iron salts: markedly decrease oral bioavailability.
  • Sucralfate: binds levothyroxine and impairs absorption.

Moderate Interactions (Monitor Closely)

  • Warfarin: levothyroxine may enhance anticoagulant effect; monitor INR.
  • Oral contraceptives: may increase levothyroxine dose requirements.
  • Amiodarone: can alter thyroid hormone metabolism and require dose adjustment.

Frequently Asked Questions

Letrox contains levothyroxine sodium, a synthetic thyroid hormone used to replace deficient endogenous hormone. It is prescribed for hypothyroidism, goitre, thyroid hormone replacement after thyroidectomy, and congenital hypothyroidism, helping to normalise metabolism, energy levels, and growth in affected patients.

Levothyroxine is a pro‑hormone that is absorbed after oral administration and converted to the active hormone triiodothyronine (T3) within cells. Both T4 and T3 bind nuclear thyroid receptors, regulating gene expression that controls basal metabolic rate, protein synthesis, and development, thereby correcting the hormonal deficit.

The appropriate dose of Letrox is individualized by the prescribing clinician. Dosage is typically titrated based on serum thyroid‑stimulating hormone (TSH) and free T4 levels, patient age, weight, cardiac status, and the presence of other medical conditions. Patients should follow the exact regimen provided by their healthcare professional.

Levothyroxine is classified as a pregnancy‑category drug where the benefits usually outweigh potential risks because untreated hypothyroidism can harm both mother and fetus. It is considered compatible with breastfeeding, as only small amounts pass into milk. Nonetheless, therapy should be managed by a qualified obstetric or endocrine specialist.

To place an order, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing a formal quotation, availability, shipping details, and any necessary import documentation.

Letrox provides levothyroxine sodium, the same active ingredient found in other generic and brand‑name thyroid hormone tablets. Differences among products are usually related to excipients, bioavailability, and regulatory approvals. Clinicians may choose Letrox for its EU‑compliant manufacturing standards, but therapeutic equivalence is expected when dosing is appropriately adjusted.

Letrox tablets should be stored at room temperature, below 25 °C, in the original blister pack or container to protect them from moisture and light. Do not store in humid environments such as bathrooms, and keep out of reach of children. No refrigeration is required.

Letrox is taken orally, usually once daily on an empty stomach, at least 30 minutes before breakfast or any other medication. Swallow the tablet whole with a full glass of water. Consistency in timing and food intake helps maintain stable serum hormone levels.

Serious risks include overtreatment leading to hyperthyroidism, which can cause cardiac arrhythmias, angina, myocardial infarction, bone loss, and severe anxiety. Patients with pre‑existing heart disease or untreated adrenal insufficiency are particularly vulnerable and should be monitored closely for symptoms such as palpitations, chest pain, or sudden weight loss.

Letrox is contraindicated in individuals with known hypersensitivity to levothyroxine or any tablet excipients, untreated adrenal insufficiency, and acute myocardial infarction. Caution is also advised for patients with severe cardiovascular disease, uncorrected thyrotoxicosis, or those taking medications that may cause dangerous interactions without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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