Product image of Letrox (Levothyroxine Sodium, Hydrate) supplied by GNH India

Letrox

Active Ingredient:
Levothyroxine Sodium, Hydrate
Origin:
EU

Letrox (Levothyroxine Sodium, Hydrate)

Levothyroxine sodium hydrate, the active ingredient in Letrox, is a thyroid hormone presented as an oral tablet for oral use. It replaces deficient endogenous thyroid hormone and is used to treat hypothyroidism, support hormone replacement after thyroidectomy, and manage goiter.

GNH India supplies Letrox as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for endocrine therapy needs across multiple regions, including Europe, Asia and Africa.

Manufacturer / TM Owner

Berlin-Chemie Ag

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Indications & Clinical Uses

Letrox (levothyroxine sodium hydrate) is used to restore thyroid hormone levels in disorders of thyroid hormone deficiency.

  • Hypothyroidism: restores normal metabolic rate and alleviates symptoms of low thyroid function.
  • Post‑thyroidectomy hormone replacement: provides the missing thyroid hormone after surgical removal of the thyroid gland.
  • Goiter: helps reduce thyroid gland enlargement by normalising hormone feedback mechanisms.

How It Works

  • Levothyroxine sodium hydrate is a synthetic form of the endogenous hormone thyroxine (T4). After oral absorption, it circulates bound to plasma proteins and is converted by peripheral deiodinases into the active hormone triiodothyronine (T3). The resulting T3 binds nuclear thyroid hormone receptors, modulating gene transcription that regulates basal metabolic rate, growth, and development.

Side Effects

Adverse reactions may occur with levothyroxine therapy.

Common Side Effects

  • Headache
  • Insomnia
  • Palpitations
  • Weight loss

Serious or Rare Side Effects

  • Cardiac arrhythmia
  • Angina pectoris
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

When prescribing levothyroxine, clinicians should consider several safety measures.

  • Dose adjustment: required in elderly patients or those with cardiac disease.
  • Monitoring: periodic assessment of serum TSH and free T4 levels is essential.
  • Contraindications: avoid use in untreated adrenal insufficiency.
  • Pregnancy: prescribe only if clearly needed after risk‑benefit evaluation.
  • Drug interactions: review concomitant medications that may affect absorption or hormone levels.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Levothyroxine may interact with several medicines, influencing its absorption or activity.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium
  • Calcium supplements
  • Iron supplements
  • Warfarin (may increase INR)
  • Amiodarone (alters thyroid hormone metabolism)

Moderate Interactions (Monitor Closely)

  • Beta‑blockers (can mask symptoms of hyperthyroidism)
  • Statins (potential impact on thyroid hormone metabolism)

Frequently Asked Questions

Letrox contains levothyroxine sodium hydrate, a synthetic thyroid hormone used to treat hypothyroidism, to replace missing hormone after thyroidectomy, and to manage goiter by normalising thyroid hormone feedback.

After oral absorption, levothyroxine sodium hydrate is converted to the active hormone triiodothyronine (T3). T3 binds nuclear thyroid receptors, influencing gene expression that controls metabolism, growth, and development, thereby correcting hormone deficiency.

The appropriate dose of Letrox is individualized. A qualified prescriber determines the exact amount based on the patient’s age, weight, thyroid function tests, and clinical response, and may adjust it over time.

Levothyroxine is classified as a pregnancy‑category drug that may be used when clearly needed. The prescriber evaluates risks and benefits for both mother and fetus. Breastfeeding is generally considered compatible, but monitoring of infant thyroid status may be advised.

To order Letrox, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrox provides levothyroxine sodium hydrate, the same active ingredient found in other synthetic T4 preparations. Differences among products are usually related to formulation, bioavailability, and regulatory approvals. Clinical efficacy is comparable when dosing is appropriately adjusted.

Letrox should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight, and excessive heat to maintain potency.

Letrox is taken orally, usually on an empty stomach 30‑60 minutes before breakfast. The tablet should be swallowed whole with a glass of water and not crushed or chewed.

Serious risks include cardiac arrhythmias, angina, and severe allergic reactions such as anaphylaxis. Over‑replacement can lead to hyperthyroid symptoms, which may precipitate heart problems, especially in patients with pre‑existing cardiac disease.

Letrox is contraindicated in patients with untreated adrenal insufficiency, acute myocardial infarction, or known hypersensitivity to levothyroxine or any excipients. It should also be avoided in individuals who are not thyroid‑deficient without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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