Product image of Letrozol Accord (Letrozole) supplied by GNH India

Letrozol Accord

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Accord (Letrozole)

Letrozole, the active ingredient in Letrozol Accord, is an aromatase inhibitor presented as an oral tablet for oral administration. By blocking the aromatase enzyme, it lowers peripheral estrogen synthesis and is indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women.

GNH India supplies Letrozol Accord as a licensed, GDP‑compliant product sourced from the European Union market, providing reliable access to oncology centres, hospitals and pharmacies worldwide through its international distribution network and ensuring compliance with local regulatory requirements.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Letrozole is an aromatase inhibitor used in the management of estrogen‑dependent breast cancer.

  • Hormone receptor‑positive early‑stage breast cancer: improves disease‑free survival as adjuvant therapy in postmenopausal women.
  • Hormone receptor‑positive metastatic breast cancer: reduces tumor progression and extends overall survival in postmenopausal patients.
  • Hormone receptor‑positive locally advanced breast cancer: used to shrink tumors before surgery or radiation in postmenopausal women.

How It Works

  • Letrozole reversibly binds to the heme group of the aromatase enzyme (CYP19A1), inhibiting the conversion of androstenedione and testosterone into estrone and estradiol. This reduction in peripheral estrogen levels diminishes estrogen‑driven tumor proliferation in hormone‑sensitive breast cancer cells.

Side Effects

Adverse reactions may occur with letrozole therapy.

Common Side Effects

  • Hot flashes
  • Joint and muscle pain
  • Nausea or vomiting
  • Fatigue

Serious or Rare Side Effects

  • Severe liver dysfunction
  • Pulmonary embolism or deep‑vein thrombosis
  • Bone fractures due to decreased bone mineral density

Precautions & Warnings

Before initiating letrozole, consider the following precautions.

  • Monitor bone health: assess bone mineral density periodically.
  • Evaluate liver function: perform baseline and periodic liver enzyme tests.
  • Assess cardiovascular risk: watch for signs of thrombosis or hypertension.
  • Review concomitant medications: avoid strong CYP2C19 inhibitors that may increase exposure.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Letrozole may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Strong CYP2C19 inhibitors (e.g., fluconazole): may increase letrozole plasma levels.
  • Estrogen‑containing hormone therapy: antagonizes therapeutic effect.
  • Tamoxifen: combined use may reduce efficacy of both agents.

Moderate Interactions (Monitor Closely)

  • CYP2C19 substrates (e.g., clopidogrel): may have altered metabolism.
  • Anticoagulants (e.g., warfarin): monitor INR as letrozole may affect clotting risk.
  • Antidepressants (e.g., SSRIs): observe for additive fatigue or dizziness.

Frequently Asked Questions

Letrozol Accord contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women, including early‑stage, locally advanced, and metastatic disease.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogens. This lowers circulating estrogen levels, reducing the growth stimulus for estrogen‑dependent breast cancer cells.

The dosage of letrozole is determined by the prescribing clinician based on the patient’s condition, renal and hepatic function, and treatment guidelines. Patients should follow the prescriber’s instructions exactly.

Letrozole is contraindicated in pregnancy because it can harm the fetus. It is also not recommended while breastfeeding, as it may pass into breast milk and affect the infant. Women of child‑bearing potential should use effective contraception.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a longer half‑life and higher potency than earlier agents such as anastrozole. Clinical studies show comparable efficacy, with a safety profile that includes similar estrogen‑related side effects but a slightly higher risk of bone density loss.

Letrozol Accord should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain stability.

Letrozol Accord is taken orally, usually as a tablet swallowed with water. It is taken once daily, preferably at the same time each day, and may be taken with or without food as directed by the prescriber.

Serious risks include severe liver injury, pulmonary embolism or deep‑vein thrombosis, and significant bone loss leading to fractures. Patients should be monitored regularly for liver function, signs of thrombosis, and bone mineral density.

Letrozol Accord should not be used in premenopausal women, pregnant or breastfeeding individuals, and patients with known hypersensitivity to letrozole or any component of the formulation. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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