Product image of Letrozol Accord (Letrozole) supplied by GNH India

Letrozol Accord

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Accord (Letrozole)

Letrozole, the active ingredient in Letrozol Accord, is a aromatase inhibitor presented as an oral tablet for oral use. It is indicated for the treatment of postmenopausal estrogen receptor‑positive breast cancer, helping to reduce estrogen‑driven tumor growth.

GNH India supplies Letrozol Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Letrozol Accord is an aromatase inhibitor used in the management of hormone‑sensitive breast cancer.

  • Postmenopausal estrogen receptor‑positive breast cancer: reduces risk of disease recurrence.
  • Adjuvant therapy for hormone‑responsive breast cancer: improves disease‑free survival after surgery.
  • Metastatic estrogen receptor‑positive breast cancer: slows tumor progression and prolongs survival.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, a non‑steroidal inhibitor that blocks the conversion of androgens to estrogens. By decreasing systemic estrogen levels, it deprives estrogen‑dependent tumor cells of growth stimulation, thereby inhibiting cancer proliferation in postmenopausal patients.

Side Effects

Adverse reactions may occur with Letrozol Accord and should be monitored.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aches in joints and muscles.
  • Nausea: mild stomach upset.
  • Fatigue: feeling unusually tired.

Serious or Rare Side Effects

  • Severe liver injury: jaundice or markedly elevated liver enzymes.
  • Blood clots: deep‑vein thrombosis or pulmonary embolism.
  • Allergic reaction: rash, swelling, or difficulty breathing.

Precautions & Warnings

Before initiating therapy with Letrozol Accord, several safety considerations are recommended.

  • Monitor bone health: assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Assess liver function: perform baseline and periodic liver enzyme tests.
  • Evaluate cardiovascular risk: watch for signs of thrombosis or hypertension.
  • Avoid use in pregnancy: letrozole is contraindicated in pregnant women (Category X).
  • Use with caution in elderly patients: adjust monitoring for frailty and comorbidities.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Letrozol Accord can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Estrogen‑containing hormone therapy: antagonizes letrozole’s effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly lower plasma concentrations.
  • Tamoxifen: opposing mechanisms may diminish therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • Warfarin: potential alteration of anticoagulant effect, monitor INR.
  • SSRIs (e.g., fluoxetine): may affect metabolism, observe for side‑effect changes.
  • Statins: possible increased risk of muscle toxicity, assess patient tolerance.

Frequently Asked Questions

Letrozol Accord contains letrozole, an aromatase inhibitor prescribed for postmenopausal women with estrogen receptor‑positive breast cancer. It helps lower estrogen levels, thereby slowing the growth of hormone‑dependent tumors and reducing the risk of disease recurrence.

Letrozole blocks the aromatase enzyme, which converts androgens into estrogens. By inhibiting this conversion, systemic estrogen concentrations fall, depriving estrogen‑sensitive cancer cells of a key growth signal and limiting tumor proliferation.

The specific dose of Letrozol Accord is determined by the prescribing clinician based on the patient’s medical condition, weight, renal and hepatic function, and treatment goals. Only a qualified health professional should set the dosing regimen.

Letrozol Accord is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as it may pass into milk and affect the infant.

To request Letrozol Accord, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Letrozol Accord (letrozole) is a non‑steroidal, reversible aromatase inhibitor with a long half‑life, offering once‑daily dosing. Compared with anastrozole, it may provide slightly higher estrogen suppression, while exemestane is a steroidal, irreversible inhibitor. Choice depends on efficacy, tolerability, and individual patient factors.

Letrozol Accord should be stored at room temperature, below 25 °C, in the original packaging to protect it from moisture and light. Keep the tablets out of reach of children and do not use if the packaging is damaged.

Letrozol Accord is taken orally, usually as a single tablet swallowed with water. It is typically taken once daily, with or without food, as directed by the prescribing physician.

Serious risks include severe liver injury, blood clot formation such as deep‑vein thrombosis or pulmonary embolism, and potentially life‑threatening allergic reactions. Patients should be monitored for signs of jaundice, unexplained swelling, shortness of breath, or rash and seek immediate medical attention if they occur.

Letrozol Accord should not be used by pregnant women, individuals with known hypersensitivity to letrozole or any component of the formulation, and patients with severe liver impairment. Caution is also advised for those with a history of cardiovascular disease or osteoporosis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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