Product image of Letrozol Accord (Letrozole) supplied by GNH India

Letrozol Accord

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Accord (Letrozole)

Letrozole, the active ingredient in Letrozol Accord, is a aromatase inhibitor presented as an oral tablet for oral use. It is employed in the treatment of hormone receptor‑positive breast cancer in postmenopausal women.

GNH India supplies Letrozol Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Letrozole acts on the estrogen‑dependent breast cancer pathway and is indicated for several stages of the disease.

  • Adjuvant treatment of hormone receptor‑positive breast cancer: reduces risk of recurrence after surgery.
  • Metastatic hormone receptor‑positive breast cancer: slows disease progression in advanced cases.
  • Neoadjuvant therapy for breast cancer: shrinks tumors before definitive surgery.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, which converts androgens to estrogens in peripheral tissues. By blocking this conversion, systemic estrogen levels decline, depriving estrogen‑dependent tumor cells of growth stimulation and thereby inhibiting tumor proliferation.

Side Effects

Letrozole may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Hot flashes: transient episodes of intense warmth.
  • Joint pain: aching or stiffness in joints.
  • Fatigue: persistent tiredness.
  • Nausea: mild upset stomach.
  • Headache: occasional throbbing pain.
  • Increased cholesterol: elevation of blood lipid levels.

Serious or Rare Side Effects

  • Osteoporosis: decreased bone mineral density leading to fractures.
  • Deep vein thrombosis: formation of blood clots in veins.
  • Liver dysfunction: abnormal liver enzyme elevations.
  • Severe allergic reaction: rash, swelling, or breathing difficulty.
  • Cardiovascular events: increased risk of heart disease.
  • Vision changes: blurred or altered vision.

Precautions & Warnings

Before initiating Letrozole therapy, consider the following safety measures.

  • Bone health assessment: evaluate risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Cardiovascular monitoring: check blood pressure and lipid profile regularly.
  • Liver function tests: perform baseline and periodic liver enzyme assessments.
  • Drug interactions: review concomitant medications for potential interactions.
  • Pregnancy contraindication: avoid use in pregnant or nursing women; effective contraception required.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Letrozole can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce Letrozole plasma levels.
  • Tamoxifen: antagonistic effect on estrogen suppression.

Moderate Interactions (Monitor Closely)

  • CYP2A6 inhibitors (e.g., fluvoxamine): may increase Letrozole exposure.
  • Anticoagulants (e.g., warfarin): may enhance bleeding risk.
  • Cholesterol‑lowering agents (e.g., statins): monitor lipid changes.
  • Hormone replacement therapy: may diminish therapeutic effect.
  • SSRIs/SNRIs: potential additive effects on mood or fatigue.

Frequently Asked Questions

Letrozol Accord contains letrozole, an aromatase inhibitor prescribed for hormone receptor‑positive breast cancer in postmenopausal women, including adjuvant, metastatic, and neoadjuvant settings.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogens, which lowers circulating estrogen levels and reduces stimulation of estrogen‑dependent tumor cells.

The dosage of Letrozol Accord is determined by the prescribing physician based on the patient’s clinical condition and treatment protocol.

Letrozol Accord is classified as pregnancy category X; it is contraindicated in pregnancy and not recommended while breastfeeding due to potential harm to the fetus or infant.

To order Letrozol Accord, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and import documentation.

Letrozol Accord, as an aromatase inhibitor, differs from selective estrogen receptor modulators like tamoxifen by directly lowering estrogen production rather than blocking its receptor, offering an alternative mechanism for hormone‑dependent breast cancer treatment.

Letrozol Accord should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight to maintain stability.

Letrozol Accord is taken orally, typically as a tablet swallowed with water, following the dosing schedule prescribed by the treating physician.

Serious risks include osteoporosis leading to fractures, deep vein thrombosis, liver dysfunction, severe allergic reactions, and cardiovascular events; patients should be monitored regularly for these conditions.

Letrozol Accord should not be used by pregnant or nursing women, individuals with known hypersensitivity to letrozole, or patients with severe liver impairment without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Letrozole

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT