Product image of Letrozol Accord (Letrozole) supplied by GNH India

Letrozol Accord

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Accord (Letrozole)

Letrozole, the active ingredient in Letrozol Accord, is an aromatase inhibitor presented as an oral tablet for systemic use. It reduces estrogen production and is employed in the treatment of hormone receptor‑positive breast cancer in postmenopausal women through reversible inhibition of the aromatase enzyme.

GNH India supplies Letrozol Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide. Our distribution network ensures reliable delivery, regulatory compliance, and quality assurance for hospitals, pharmacies, and clinical trial sites across Europe, Asia, Africa, and the Americas.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

  • Letrozole is used in endocrine therapy targeting estrogen‑dependent breast cancer.
  • Hormone receptor‑positive breast cancer in postmenopausal women: reduces tumor growth by lowering circulating estrogen levels.
  • Adjuvant treatment of early‑stage hormone receptor‑positive breast cancer: helps prevent disease recurrence after surgery.
  • Metastatic hormone receptor‑positive breast cancer in postmenopausal women: provides disease control when combined with other systemic agents.

How It Works

  • Letrozole binds reversibly to the aromatase enzyme, inhibiting its activity and thereby decreasing the peripheral conversion of androgens (androstenedione and testosterone) into estrogens (estrone and estradiol). This reduction in estrogen levels limits the hormonal stimulation of estrogen‑dependent tumor cells, contributing to antineoplastic effects in breast cancer.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: sudden feeling of warmth, often with sweating.
  • Joint and muscle pain: aching or stiffness in muscles, joints, or limbs.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated liver enzymes, or hepatic failure.
  • Bone fracture (osteoporosis): increased risk of fractures due to reduced bone mineral density.
  • Allergic reactions: rash, swelling, or anaphylaxis requiring immediate medical attention.

Precautions & Warnings

  • When prescribing Letrozol Accord, clinicians should consider several safety measures.
  • Bone health monitoring: assess bone mineral density regularly due to risk of osteoporosis.
  • Liver function testing: evaluate hepatic enzymes before and during therapy.
  • Cardiovascular assessment: monitor for hypertension or thromboembolic events.
  • Pregnancy avoidance: contraindicated in pregnancy; ensure effective contraception.
  • Drug interactions: review concomitant medications that affect estrogen levels or CYP enzymes.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Letrozol Accord can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Estrogen‑containing hormone replacement therapy: antagonizes letrozole effect.
  • Tamoxifen: may reduce efficacy of letrozole when used concurrently.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): decrease plasma concentrations of letrozole.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluoxetine, fluconazole): may increase letrozole exposure.
  • Anticoagulants (e.g., warfarin): monitor INR as letrozole may affect metabolism.
  • Statins: observe for increased muscle toxicity.

Frequently Asked Questions

Letrozol Accord contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used in both early‑stage (adjuvant) and metastatic settings to reduce estrogen‑driven tumor growth.

Letrozole reversibly inhibits the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues. By lowering estrogen levels, the drug diminishes hormonal stimulation of estrogen‑dependent breast cancer cells, thereby slowing tumor progression.

The dosage of Letrozol Accord is determined by the prescribing clinician based on the patient’s clinical condition, renal and hepatic function, and treatment goals. Physicians typically follow approved dosing guidelines, and patients should follow the prescribed regimen exactly.

Letrozol Accord is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as the drug may be excreted in milk and affect the infant.

To order Letrozol Accord, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Letrozol Accord (letrozole) is a non‑steroidal aromatase inhibitor similar to anastrozole but generally considered more potent on a milligram‑per‑milligram basis. Exemestane, a steroidal inhibitor, has a different binding profile. Choice of agent depends on efficacy, tolerability, patient comorbidities, and physician preference.

Letrozol Accord should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children. Do not store in bathrooms or near heat sources.

Letrozol Accord is taken orally as a tablet. Patients should swallow the tablet whole with water, with or without food, as directed by their healthcare provider. Consistency in the timing of each dose helps maintain stable drug levels.

The most serious risks include significant bone loss leading to fractures, severe liver injury, and rare but potentially life‑threatening allergic reactions such as anaphylaxis. Patients should report new bone pain, jaundice, or signs of hypersensitivity promptly to their clinician.

Letrozol Accord should not be used by pregnant or breastfeeding women, premenopausal women, patients with severe hepatic impairment, or individuals with known hypersensitivity to letrozole or any excipients in the tablet. Contraindications are outlined in the product’s prescribing information.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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