Product image of Letrozol Accord (Letrozole) supplied by GNH India

Letrozol Accord

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Accord (Letrozole)

Letrozole, the active ingredient in Letrozol Accord, is an aromatase inhibitor presented as an oral tablet for oral use. Approved in the European Union, it is used in endocrine therapy to reduce estrogen production in hormone receptor‑positive breast cancer among postmenopausal women.

GNH India supplies Letrozol Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide, with full regulatory compliance and quality assurance. The product meets EU pharmacopeial standards and is manufactured under GMP conditions.

Manufacturer / TM Owner

Accord Healthcare Polska Sp. Z O.O.

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Indications & Clinical Uses

Letrozole is an aromatase inhibitor used in the treatment of hormone‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer (postmenopausal): Reduces estrogen synthesis to inhibit tumor growth.
  • Adjuvant therapy for early‑stage breast cancer: Decreases risk of recurrence after surgery.
  • Metastatic breast cancer (postmenopausal): Provides disease control when other endocrine agents are insufficient.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, blocking the conversion of androgens to estrogens in peripheral tissues. By inhibiting this key step in estrogen biosynthesis, circulating estrogen levels fall, depriving estrogen‑dependent tumor cells of growth stimulation and thereby slowing disease progression.

Side Effects

Letrozole may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Hot flashes: Sudden feeling of warmth and sweating.
  • Arthralgia: Joint pain or stiffness.
  • Fatigue: Persistent tiredness.
  • Nausea: Upset stomach or urge to vomit.
  • Headache: Mild to moderate cranial pain.
  • Insomnia: Difficulty falling or staying asleep.

Serious or Rare Side Effects

  • Severe liver injury: Jaundice, elevated enzymes.
  • Osteoporotic fractures: Increased bone fragility.
  • Pulmonary embolism: Sudden shortness of breath.
  • Deep vein thrombosis: Leg swelling and pain.
  • Anaphylaxis: Rapid onset of allergic reaction.
  • Hypercholesterolemia: Elevated blood cholesterol levels.

Precautions & Warnings

When prescribing Letrozol Accord, clinicians should consider several safety measures.

  • Monitor bone density: Assess risk of osteoporosis and fractures.
  • Evaluate liver function: Perform baseline and periodic hepatic tests.
  • Assess cardiovascular risk: Watch for thromboembolic events.
  • Contraindicated in pregnancy: Category X, avoid use in pregnant women.
  • Caution with estrogen therapy: May reduce efficacy of Letrozole.
  • Store at ambient temperature: Keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Letrozole can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Concomitant estrogen replacement therapy: Opposes aromatase inhibition.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): Decrease Letrozole plasma levels.
  • Other aromatase inhibitors: Redundant pharmacologic effect.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluoxetine): May increase Letrozole exposure.
  • Warfarin: Potential alteration of anticoagulant effect.
  • Glucocorticoids: May affect estrogen metabolism.

Frequently Asked Questions

Letrozol Accord contains letrozole, an aromatase inhibitor indicated for the endocrine treatment of hormone receptor‑positive breast cancer in postmenopausal women, including adjuvant and metastatic settings.

Letrozole reversibly inhibits the aromatase enzyme, which converts androgens to estrogens. By blocking this conversion, estrogen levels drop, limiting the growth stimulus for estrogen‑dependent breast cancer cells.

The prescribed dose of Letrozol Accord is determined by the treating physician based on the patient’s clinical condition, renal and hepatic function, and other individual factors. No fixed regimen is provided here.

Letrozol Accord is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to potential fetal harm. It is also not recommended during breastfeeding because it may pass into milk and affect the infant.

To request Letrozol Accord, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Letrozol Accord (letrozole) is a non‑steroidal aromatase inhibitor with a long half‑life, offering once‑daily dosing. Compared with anastrozole or exemestane, letrozole often provides slightly higher estrogen suppression, but choice depends on individual patient response and tolerability.

Letrozol Accord tablets should be stored at ambient temperature, below 25 °C, in the original packaging, protected from moisture and direct sunlight. Keep out of reach of children.

Letrozol Accord is taken orally, usually with or without food, as a single tablet per day. Patients should follow the prescribing physician’s instructions regarding timing and any accompanying dietary considerations.

Serious risks include severe liver injury, osteoporotic fractures, and rare thromboembolic events such as pulmonary embolism or deep‑vein thrombosis. Patients should be monitored regularly for signs of these conditions.

Letrozol Accord should not be used by pregnant women, individuals with known hypersensitivity to letrozole or any tablet component, and patients with severe hepatic impairment without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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