Product image of Letrozol Accord (Letrozole) supplied by GNH India

Letrozol Accord

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Accord (Letrozole)

Letrozole, the active ingredient in Letrozol Accord, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed in the treatment of hormone receptor‑positive breast cancer in postmenopausal women, both in adjuvant and metastatic settings.

GNH India supplies Letrozol Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide. The company adheres to stringent quality standards and provides reliable global distribution to hospitals, pharmacies and cancer treatment facilities.

Manufacturer / TM Owner

Accord Healthcare S.L.U.

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Indications & Clinical Uses

Letrozole is used in endocrine therapy for hormone‑dependent breast cancer.

  • Adjuvant treatment of hormone receptor‑positive breast cancer in postmenopausal women: reduces risk of disease recurrence after surgery.
  • Metastatic hormone receptor‑positive breast cancer in postmenopausal women: helps control tumor progression and prolongs survival.
  • Estrogen‑dependent breast cancer in postmenopausal patients: provides systemic endocrine inhibition of estrogen production.

How It Works

  • Letrozole selectively and non‑steroidally inhibits the aromatase enzyme, which converts androstenedione and testosterone to estrone and estradiol in peripheral tissues. By blocking this conversion, systemic estrogen levels fall, depriving estrogen‑dependent tumor cells of a growth stimulus. The inhibition is reversible and dose‑dependent, leading to sustained suppression of circulating estrogen in postmenopausal patients.

Side Effects

Letrozole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: arthralgia and myalgia.
  • Fatigue: persistent tiredness.
  • Nausea: mild gastrointestinal upset.

Serious or Rare Side Effects

  • Severe liver injury: elevated transaminases, jaundice.
  • Bone fracture: increased risk of osteoporosis‑related fractures.
  • Allergic reaction: rash, angioedema, or anaphylaxis.

Precautions & Warnings

When prescribing Letrozole, clinicians should observe several precautionary measures to ensure patient safety.

  • Assess bone health: monitor bone mineral density and consider calcium/vitamin D supplementation.
  • Evaluate liver function: avoid use in patients with severe hepatic impairment.
  • Monitor cardiovascular status: be alert for thromboembolic events, especially in high‑risk individuals.
  • Contraindicated in pregnancy: category X, must not be used in pregnant women.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Letrozole can interact with other medicines, influencing its effectiveness or safety.

Major Interactions (Avoid)

  • Estrogen replacement therapy: antagonizes Letrozole’s aromatase inhibition, reducing therapeutic benefit.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): markedly lower Letrozole plasma concentrations.
  • Tamoxifen: opposing mechanisms may diminish efficacy of both agents.

Moderate Interactions (Monitor Closely)

  • Warfarin: Letrozole may increase INR, requiring more frequent coagulation monitoring.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine): may affect Letrozole metabolism, monitor for side‑effect changes.

Frequently Asked Questions

Letrozol Accord contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used both as adjuvant therapy after surgery and for managing metastatic disease, helping to slow tumor growth by lowering estrogen levels.

Letrozole works by selectively and non‑steroidally blocking the aromatase enzyme, which converts adrenal and ovarian androgens into estrogen. By inhibiting this conversion, circulating estrogen concentrations fall, depriving estrogen‑dependent cancer cells of a key growth signal.

The specific dose of Letrozol Accord is determined by the prescribing physician based on the patient’s clinical condition, treatment setting and individual factors. Healthcare providers follow established guidelines and adjust the regimen as needed for safety and efficacy.

Letrozol Accord is classified as pregnancy category X, meaning it is contraindicated in pregnant women because it can cause fetal harm. It is also not recommended during breastfeeding, as it may pass into milk and affect the infant.

To order Letrozol Accord, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozol Accord (letrozole) is a third‑generation aromatase inhibitor with high potency and a long half‑life, offering once‑daily dosing. Compared with earlier agents such as anastrozole, letrozole generally provides slightly greater estrogen suppression, though clinical choice depends on individual patient factors and physician preference.

Letrozol Accord should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight and heat sources. Do not store in the bathroom or near a kitchen sink to maintain product stability.

Letrozol Accord is taken orally, usually as a whole tablet swallowed with water. It is administered once daily, preferably at the same time each day, and can be taken with or without food. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks include severe liver injury, significant bone loss leading to fractures, and rare but life‑threatening allergic reactions such as anaphylaxis. Patients should report signs of jaundice, persistent bone pain, or any rash with swelling promptly to their physician.

Letrozol Accord should not be used by pregnant women, individuals with known hypersensitivity to letrozole or any tablet excipients, and patients with severe hepatic impairment. Caution is also advised for those with pre‑existing osteoporosis or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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