Product image of Letrozol Alter (Letrozole) supplied by GNH India

Letrozol Alter

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Alter (Letrozole)

Letrozole, the active ingredient in Letrozol Alter, is an aromatase inhibitor presented as an oral tablet for oral use. It is employed in the endocrine therapy of hormone receptor‑positive breast cancer in postmenopausal women, reducing estrogen production that can fuel tumor growth.

GNH India supplies Letrozol Alter as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for oncology treatments across global markets today.

Manufacturer / TM Owner

Alter S.A.

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Indications & Clinical Uses

  • Letrozole is an aromatase inhibitor used in the management of estrogen‑dependent breast cancer.
  • Hormone receptor‑positive early breast cancer: reduces risk of recurrence.
  • Hormone receptor‑positive advanced/metastatic breast cancer: slows disease progression.
  • Adjuvant endocrine therapy in postmenopausal women: improves disease‑free survival.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, inhibiting the conversion of adrenal and peripheral androgen precursors into estrone and estradiol. By markedly lowering circulating estrogen levels, it deprives estrogen‑dependent breast tumor cells of a growth stimulus, thereby limiting tumor proliferation.

Side Effects

Common Side Effects

  • Hot flashes: sudden feeling of warmth, often with sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.
  • Headache: intermittent or persistent head pain.
  • Dizziness: sensation of light‑headedness or imbalance.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated liver enzymes.
  • Bone fracture: increased risk due to reduced bone density.
  • Pulmonary embolism: sudden shortness of breath, chest pain.
  • Myocardial infarction: heart attack symptoms.
  • Severe allergic reaction: rash, swelling, difficulty breathing.
  • Elevated cholesterol: significant rise in blood lipid levels.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Pregnancy: contraindicated (Category X) – do not use in pregnant women.
  • Breastfeeding: not recommended – avoid during lactation.
  • Bone health: monitor bone mineral density regularly.
  • Liver function: assess hepatic enzymes before and during treatment.
  • Cardiovascular disease: use cautiously in patients with severe heart conditions.
  • Store at ambient temperature below 25°C: keep in original packaging, protect from moisture.

Avoid Interactions

Letrozole may interact with several medicines.

Major Interactions (Avoid)

  • Estrogen replacement therapy: antagonizes letrozole’s effect.
  • Other aromatase inhibitors: additive estrogen suppression may increase toxicity.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise letrozole plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may reduce efficacy.
  • Warfarin: monitor INR for altered anticoagulation.
  • Selective serotonin reuptake inhibitors: possible effect on metabolism.
  • Antacids containing aluminum or magnesium: may affect absorption.

Frequently Asked Questions

Letrozol Alter contains letrozole, an aromatase inhibitor indicated for the endocrine treatment of hormone receptor‑positive breast cancer in postmenopausal women, including adjuvant and metastatic settings.

Letrozole reversibly blocks the aromatase enzyme, preventing the conversion of androgens to estrogen. This reduction in estrogen levels deprives estrogen‑dependent breast cancer cells of a growth signal, slowing tumor progression.

The prescribed dose of Letrozol Alter is determined by the treating physician based on the patient’s clinical condition, treatment setting, and relevant guidelines. Dosage should not be altered without medical advice.

Letrozol Alter is classified as pregnancy Category X, meaning it is contraindicated in pregnant women. It is also not recommended during breastfeeding because it may pass into breast milk and affect the infant.

To order Letrozol Alter, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Letrozol Alter (letrozole) is a third‑generation aromatase inhibitor with a long half‑life, offering once‑daily dosing. Compared with earlier agents such as anastrozole or exemestane, letrozole often shows slightly higher potency in estrogen suppression, though clinical choice depends on individual patient factors and physician preference.

Letrozol Alter should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight to maintain stability and potency.

Letrozol Alter is taken orally, usually as a tablet swallowed with water. It is generally administered once daily, preferably at the same time each day, following the prescribing physician’s instructions.

Serious risks include severe liver injury, bone fractures due to decreased bone density, cardiovascular events such as myocardial infarction, and rare but severe allergic reactions. Patients should be monitored regularly for these potential complications.

Letrozol Alter should not be used by pregnant or breastfeeding women, patients with known hypersensitivity to letrozole, or individuals with severe liver impairment or uncontrolled cardiovascular disease without careful medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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