Product image of Letrozol Amperlem (Letrozole) supplied by GNH India

Letrozol Amperlem

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Amperlem (Letrozole)

Letrozole, the active ingredient in Letrozol Amperlem, is an aromatase inhibitor presented as an oral tablet for oral use. It is used to treat postmenopausal hormone receptor‑positive breast cancer and as adjuvant therapy for early‑stage disease.
GNH India supplies Letrozol Amperlem as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Towa Pharmaceutical S.A.

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Indications & Clinical Uses

  • Letrozol Amperlem is an aromatase inhibitor used in hormone‑driven breast cancer management.
  • Postmenopausal hormone receptor‑positive breast cancer: reduces estrogen‑driven tumor growth and lowers recurrence risk.
  • Adjuvant therapy for early‑stage breast cancer: decreases estrogen levels to prevent disease progression.
  • Estrogen‑dependent breast cancer: limits peripheral conversion of androgens to estrogen, inhibiting tumor proliferation.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, blocking the conversion of androstenedione and testosterone into estrone and estradiol. By suppressing peripheral estrogen synthesis, circulating estrogen concentrations fall, depriving estrogen‑responsive tumor cells of a growth stimulus and thereby slowing or halting cancer progression.

Side Effects

Letrozol Amperlem may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Hot flashes: sudden feeling of warmth, often with sweating.
  • Joint and muscle pain: aching or stiffness in limbs.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea or mild gastrointestinal upset.
  • Headache: intermittent or persistent head pain.
  • Increased sweating.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, elevated enzymes, hepatic failure.
  • Bone fractures: decreased bone mineral density leading to fractures.
  • Pulmonary embolism: sudden shortness of breath, chest pain.
  • Severe allergic reaction: rash, swelling, anaphylaxis.
  • Elevated cholesterol levels: risk of cardiovascular events.
  • QT interval prolongation: potential cardiac arrhythmias.

Precautions & Warnings

  • Before initiating Letrozol Amperlem, clinicians should consider several safety measures.
  • Monitor bone health: assess bone mineral density regularly.
  • Evaluate liver function: perform baseline and periodic liver enzyme tests.
  • Assess cardiovascular risk: review history of thrombosis or hyperlipidaemia.
  • Avoid use in premenopausal women: drug is ineffective and may cause ovarian stimulation.
  • Review concomitant medications: check for interactions that may alter letrozole levels.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Letrozol Amperlem can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Estrogen‑containing products: may counteract letrozole’s estrogen‑lowering effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): can markedly reduce letrozole exposure.
  • Warfarin: may increase anticoagulant effect and bleeding risk.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluconazole): may raise letrozole plasma levels.
  • Selective serotonin reuptake inhibitors (SSRIs): potential modest increase in side‑effects.
  • Statins: monitor for additive liver enzyme elevations.
  • Glucocorticoids: observe for enhanced bone density loss.

Frequently Asked Questions

Letrozol Amperlem contains letrozole, an aromatase inhibitor indicated for the treatment of postmenopausal hormone receptor‑positive breast cancer and as adjuvant therapy in early‑stage disease to reduce the risk of recurrence.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens into estrogen. This lowers circulating estrogen levels, depriving estrogen‑dependent tumor cells of a growth signal and thereby inhibiting cancer progression.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions exactly.

Letrozole is contraindicated in pregnancy because it can harm a developing fetus. Safety during breastfeeding has not been established, and breastfeeding is generally not recommended while using this medication.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole is a third‑generation aromatase inhibitor with a high potency and a long half‑life, offering once‑daily oral dosing. Compared with earlier agents such as anastrozole, letrozole often provides greater estrogen suppression, though individual response and tolerability may vary.

Store Letrozol Amperlem at temperatures below 25 °C in its original container, protecting it from moisture, heat and direct sunlight. Do not store in a bathroom or near a kitchen sink.

Letrozol Amperlem is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with water and not chewed or crushed.

Serious risks include severe liver injury, bone fractures due to decreased bone density, pulmonary embolism, and rare allergic reactions such as anaphylaxis. Patients should be monitored regularly for signs of these conditions.

Letrozol Amperlem should not be used in premenopausal women, pregnant or nursing individuals, and patients with known hypersensitivity to letrozole or any excipients. Caution is also advised for those with severe liver disease or uncontrolled cardiovascular conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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