Product image of Letrozol Azevedos (Letrozole) supplied by GNH India

Letrozol Azevedos

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Azevedos (Letrozole)

Letrozole, the active ingredient in Letrozol Azevedos, is a aromatase inhibitor presented as a tablet for oral use. It treats hormone receptor‑positive breast cancer in postmenopausal women.
GNH India supplies Letrozol Azevedos as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Laboratórios Azevedos - Indústria Farmacêutica, S.A.

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Indications & Clinical Uses

Letrozol Azevedos is an aromatase inhibitor used in the management of estrogen‑dependent breast cancer.

  • Hormone receptor‑positive breast cancer (adjuvant): Reduces risk of recurrence after surgery in postmenopausal women.
  • Hormone receptor‑positive metastatic breast cancer: Delays disease progression in postmenopausal patients with advanced disease.
  • Estrogen‑dependent breast cancer: Lowers circulating estrogen to inhibit tumor growth in eligible patients.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme, blocking the conversion of adrenal and ovarian androgens to estrone and estradiol. This inhibition markedly reduces systemic estrogen levels, depriving estrogen‑dependent breast cancer cells of a key growth stimulus and thereby slowing tumor proliferation.

Side Effects

Letrozol Azevedos may cause a range of adverse reactions.

Common Side Effects

  • Hot flashes
  • Joint or muscle pain
  • Fatigue
  • Nausea
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Severe bone loss or osteoporosis leading to fractures
  • Cardiovascular events such as hypertension or thromboembolism
  • Elevated liver enzymes or hepatic dysfunction
  • Severe allergic reactions including anaphylaxis
  • Deep vein thrombosis or pulmonary embolism
  • Significant cholesterol abnormalities

Precautions & Warnings

Before initiating therapy, several safety considerations should be reviewed.

  • Pregnancy: Contraindicated; teratogenic (Category X).
  • Bone health: Monitor bone mineral density and consider calcium/vitamin D supplementation.
  • Cardiovascular: Assess risk factors and monitor blood pressure and lipid profile regularly.
  • Liver function: Use with caution in hepatic impairment; periodic liver enzyme testing recommended.
  • Drug interactions: Review concomitant medications for CYP2A6 substrates or inhibitors.
  • Store at ambient temperature: Keep below 25°C in the original packaging, protect from moisture and light.

Avoid Interactions

Letrozol Azevedos can interact with several medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP2A6 inhibitors (e.g., fluvoxamine): May increase letrozole exposure.
  • Estrogen‑containing hormone therapy: Opposes therapeutic effect of letrozole.
  • Tamoxifen: Reduces the efficacy of letrozole when used concurrently.

Moderate Interactions (Monitor Closely)

  • CYP2A6 inducers (e.g., rifampin): May lower plasma concentrations of letrozole.
  • Anticoagulants (e.g., warfarin): Potential alteration of INR; monitor coagulation status.
  • Selective serotonin reuptake inhibitors (e.g., paroxetine): May require symptom monitoring for additive side effects.

Frequently Asked Questions

Letrozol Azevedos contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women, both as adjuvant therapy after surgery and for metastatic disease management.

Letrozole blocks the aromatase enzyme, preventing the conversion of androgens to estrogen. By lowering circulating estrogen levels, it reduces stimulation of estrogen‑dependent breast cancer cells, thereby inhibiting tumor growth.

The prescribed dose of letrozole is determined by the treating physician based on the patient’s clinical condition, renal and hepatic function, and treatment guidelines. Patients should follow the exact dosing instructions provided by their healthcare professional.

Letrozol is classified as Pregnancy Category X, indicating it is contraindicated in pregnancy due to known teratogenic risk. It is also not recommended during breastfeeding because it may pass into breast milk and affect the infant.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Letrozole, an aromatase inhibitor, lowers estrogen production, whereas tamoxifen, a selective estrogen receptor modulator, blocks estrogen receptors. In postmenopausal patients, aromatase inhibitors like letrozole often provide superior disease‑free survival, but individual choice depends on patient tolerance, comorbidities, and physician judgment.

Store Letrozol Azevedos at ambient temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture, heat, and direct light. Do not store in the bathroom or near a kitchen sink.

Letrozol Azevedos is taken orally, usually as a whole tablet with water. It can be taken with or without food, but patients should follow any specific instructions from their prescriber regarding timing relative to meals.

Serious risks include severe bone loss leading to fractures, cardiovascular events such as hypertension or thromboembolism, liver enzyme elevations, and rare allergic reactions. Patients should report new bone pain, swelling, shortness of breath, or signs of liver dysfunction promptly.

Letrozol Azevedos should not be used by pregnant or breastfeeding women, patients with known hypersensitivity to letrozole or other aromatase inhibitors, and individuals with severe hepatic impairment without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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