Product image of Letrozol-Ct Abz-Pharma (Letrozole) supplied by GNH India

Letrozol-Ct Abz-Pharma

Active Ingredient:
Letrozole
Origin:
EU

Letrozol-Ct Abz-Pharma (Letrozole)

Letrozole, the active ingredient in Letrozol-Ct Abz-Pharma, is an aromatase inhibitor presented as an oral formulation for oral use. It is indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women, where it lowers estrogen levels that can drive tumor growth.

GNH India supplies Letrozol-Ct Abz-Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide, with a focus on quality and regulatory compliance.

Manufacturer / TM Owner

Abz-Pharma Gmbh

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Indications & Clinical Uses

Letrozole is used in the management of hormone‑dependent breast cancer, targeting estrogen‑driven tumor pathways.

  • Early‑stage hormone receptor‑positive breast cancer: helps prevent recurrence after surgery.
  • Metastatic hormone receptor‑positive breast cancer: slows disease progression in advanced cases.
  • Hormone receptor‑positive breast cancer in postmenopausal women: reduces estrogen‑driven tumor growth.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme, which is responsible for converting adrenal and peripheral androgens into estrogens. By blocking this conversion, circulating estrogen concentrations fall markedly, depriving estrogen‑dependent tumor cells of a growth stimulus and thereby limiting tumor proliferation in postmenopausal patients.

Side Effects

Adverse reactions may occur with letrozole therapy.

Common Side Effects

  • Hot flashes: sudden feeling of warmth, often with sweating.
  • Joint and muscle pain: aching in knees, hips, or shoulders.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild to moderate upset stomach.

Serious or Rare Side Effects

  • Severe liver injury: jaundice, dark urine, elevated liver enzymes.
  • Bone fracture: increased risk of osteoporosis‑related breaks.
  • Thromboembolic events: deep vein thrombosis or pulmonary embolism.

Precautions & Warnings

Before initiating letrozole, several safety considerations should be reviewed.

  • Pregnancy: contraindicated (Category X); teratogenic risk.
  • Breastfeeding: not recommended; drug may pass into milk.
  • Bone health: monitor bone mineral density, consider calcium/vitamin D supplementation.
  • Liver function: assess hepatic status; dose adjustment may be needed.
  • Drug interactions: review concomitant medications for potential CYP2A6 involvement.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Letrozole may interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Estrogen replacement therapy: may counteract letrozole's estrogen‑lowering effect.
  • Strong CYP2A6 inhibitors (e.g., fluvoxamine): can raise letrozole plasma levels.
  • Tamoxifen: antagonistic action, diminishing therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • Warfarin: may increase INR and bleeding risk.
  • Diuretics: potential electrolyte disturbances.
  • SSRIs (e.g., fluoxetine): may alter letrozole metabolism.

Frequently Asked Questions

Letrozol-Ct Abz-Pharma contains letrozole, an aromatase inhibitor prescribed for hormone receptor‑positive breast cancer in postmenopausal women. It is used both as adjuvant therapy after surgery and for controlling disease in metastatic settings, where lowering estrogen levels helps slow tumor growth.

Letrozole blocks the aromatase enzyme, which converts adrenal and peripheral androgens into estrogen. By inhibiting this conversion, circulating estrogen concentrations drop, depriving estrogen‑dependent breast cancer cells of a key growth signal and thereby reducing tumor proliferation.

The specific dose of Letrozol-Ct Abz-Pharma is determined by the treating physician based on the patient’s clinical condition, renal and hepatic function, and other individual factors. Prescribers follow established oncology guidelines and adjust the regimen as needed.

Letrozol-Ct is classified as Pregnancy Category X, meaning it is contraindicated during pregnancy because it can cause fetal harm. It is also not recommended for breastfeeding mothers, as the drug may be excreted in breast milk and affect the infant.

To request Letrozol-Ct Abz-Pharma, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and required import documentation.

Letrozol-Ct (letrozole) and other aromatase inhibitors such as anastrozole and exemestane share the same mechanism of reducing estrogen synthesis. Letrozole is often considered the most potent inhibitor, offering slightly greater estrogen suppression, which can translate into marginally improved disease control in some clinical scenarios, though individual response varies.

Letrozol-Ct should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat. Do not store in bathrooms or near kitchen appliances that generate steam.

Letrozol-Ct is taken orally, usually as a tablet swallowed whole with water. The medication is typically taken once daily, at the same time each day, and can be taken with or without food, unless the prescriber advises otherwise.

Serious risks include severe liver injury, marked bone loss leading to fractures, and rare thromboembolic events such as deep‑vein thrombosis or pulmonary embolism. Patients should report signs of jaundice, unexplained bone pain, swelling of the legs, or sudden shortness of breath to their healthcare provider promptly.

Letrozol-Ct is contraindicated in pregnant women, nursing mothers, and patients with known hypersensitivity to letrozole or any component of the formulation. Caution is also advised for individuals with severe liver impairment, uncontrolled osteoporosis, or those receiving estrogen replacement therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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