Product image of Letrozol Farmoz (Letrozole) supplied by GNH India

Letrozol Farmoz

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Farmoz (Letrozole)

Letrozole, the active ingredient in Letrozol Farmoz, is an aromatase inhibitor presented as an oral tablet for oral administration. It lowers estrogen production and is indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women, helping to slow tumor growth.

GNH India supplies Letrozol Farmoz as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Farmoz - Sociedade Técnico Medicinal, S.A.

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Indications & Clinical Uses

Letrozol Farmoz is an aromatase inhibitor used in the management of estrogen‑dependent breast cancer.

  • Metastatic breast cancer: reduces tumor growth by lowering systemic estrogen levels.
  • Adjuvant therapy for early‑stage hormone receptor‑positive breast cancer: decreases risk of disease recurrence after surgery.
  • Neoadjuvant therapy in postmenopausal women: shrinks tumors before surgical resection.

How It Works

  • Letrozole selectively and competitively inhibits the aromatase enzyme (CYP19A1), which converts androstenedione and testosterone to estrone and estradiol in peripheral tissues. By blocking this conversion, systemic estrogen concentrations fall, depriving estrogen‑dependent breast cancer cells of a growth stimulus. The inhibition is reversible and dose‑dependent, providing sustained estrogen suppression with oral dosing.

Side Effects

Letrozole may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Fatigue: persistent tiredness.
  • Nausea: feeling of stomach upset.
  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Severe bone loss or osteoporosis: increased fracture risk.
  • Cardiovascular events: such as deep‑vein thrombosis.
  • Liver function abnormalities: elevated enzymes.
  • Severe allergic reactions: including anaphylaxis.
  • Pulmonary embolism: blockage in lung arteries.
  • Elevated cholesterol levels: may affect lipid profile.

Precautions & Warnings

Before initiating Letrozol Farmoz, clinicians should consider several safety measures.

  • Monitor bone mineral density: assess risk of osteoporosis and consider calcium/vitamin D supplementation.
  • Assess cardiovascular risk: evaluate history of thromboembolic disease before starting therapy.
  • Check liver function: adjust use in patients with hepatic impairment.
  • Avoid use in pregnancy: Letrozole is contraindicated due to teratogenic risk (Category X).
  • Discontinue if severe adverse reactions occur: report to healthcare provider promptly.
  • Store at below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Letrozol Farmoz can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Concurrent use with estrogen replacement therapy: negates therapeutic effect.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce plasma levels.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase exposure and toxicity.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect; monitor INR.
  • Tamoxifen: antagonistic hormonal effects; monitor clinical response.
  • Certain antidepressants (SSRIs): may affect estrogen metabolism; observe for side effects.

Frequently Asked Questions

Letrozol Farmoz contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used in metastatic, adjuvant, and neoadjuvant settings to lower estrogen levels and inhibit tumor growth.

Letrozole works by selectively blocking the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. By inhibiting this conversion, systemic estrogen concentrations fall, depriving estrogen‑dependent cancer cells of a key growth signal.

The dosage of Letrozol Farmoz is determined by the prescribing physician based on the patient’s clinical condition, treatment stage, and tolerance. The prescriber sets the exact amount and schedule, which may be adjusted during therapy.

Letrozol Farmoz is classified as Pregnancy Category X, indicating it is contraindicated in pregnancy because it can cause fetal harm. It is also not recommended while breastfeeding, as it may pass into milk and affect the infant.

To order Letrozol Farmoz, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

The primary alternative to letrozole is anastrozole, another aromatase inhibitor. Both lower estrogen levels, but letrozole is often considered slightly more potent, while anastrozole may have a marginally lower incidence of joint pain. Choice depends on individual patient response and physician preference.

Letrozol Farmoz should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Keep the product out of reach of children and avoid exposing it to excessive heat or humidity.

Letrozol Farmoz is taken orally, usually as a tablet swallowed whole with water. It is administered once daily, preferably at the same time each day, and may be taken with or without food as directed by the prescriber.

Serious risks include severe bone loss or osteoporosis, cardiovascular events such as deep‑vein thrombosis, liver function abnormalities, and rare but life‑threatening allergic reactions like anaphylaxis. Patients should be monitored regularly for these conditions.

Letrozol Farmoz should not be used by pregnant or breastfeeding women, premenopausal women, or individuals with known hypersensitivity to letrozole or other aromatase inhibitors. It is also contraindicated in patients with severe liver impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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