Product image of Letrozol Genthon (Letrozole) supplied by GNH India

Letrozol Genthon

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Genthon (Letrozole)

Letrozole, the active ingredient in Letrozol Genthon, is an aromatase inhibitor presented as an oral tablet for oral use. It reduces estrogen production and is employed in the treatment of hormone‑sensitive breast cancer in postmenopausal women.

GNH India supplies Letrozol Genthon as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide. The company adheres to EU quality standards and provides the product to hospitals, pharmacies and clinical trial sites across multiple regions. Its distribution network includes Europe, Asia, Africa and the Americas, ensuring timely delivery to qualified healthcare institutions.

Manufacturer / TM Owner

Genthon Bv

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Indications & Clinical Uses

Letrozole is used in the management of estrogen‑dependent breast cancer and related disease pathways.

  • Postmenopausal breast cancer: reduces tumor growth by lowering circulating estrogen levels.
  • Hormone‑sensitive breast cancer: slows disease progression in estrogen‑receptor positive tumors.
  • Adjuvant therapy for early‑stage breast cancer: improves disease‑free survival after surgical resection.

How It Works

  • Letrozole reversibly binds to the aromatase enzyme (CYP19A1) in peripheral tissues, inhibiting the conversion of androstenedione and testosterone into estrone and estradiol. By decreasing systemic estrogen concentrations, the drug deprives estrogen‑dependent tumor cells of a key growth stimulus, thereby limiting proliferation and promoting apoptosis in hormone‑sensitive breast cancer. The inhibition is dose‑dependent and persists as long as the drug is present in plasma, allowing clinicians to achieve sustained estrogen suppression.

Side Effects

Letrozole may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Hot flashes: sudden feeling of warmth and sweating.
  • Joint pain: aching or stiffness in knees, hips or shoulders.
  • Fatigue: persistent tiredness not relieved by rest.
  • Nausea: mild stomach upset or urge to vomit.
  • Headache: pressure or throbbing pain in the head.
  • Dizziness: light‑headedness or imbalance.

Serious or Rare Side Effects

  • Severe bone loss: increased risk of osteoporosis and fractures.
  • Thromboembolic events: deep‑vein thrombosis or pulmonary embolism.
  • Liver toxicity: elevated transaminases or hepatitis.
  • Interstitial lung disease: breathing difficulties and cough.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Cardiac arrhythmia: QT interval prolongation.

Precautions & Warnings

Before initiating letrozole therapy, clinicians should evaluate several safety considerations.

  • Monitor bone health: assess bone mineral density and consider calcium/vitamin D supplementation.
  • Assess cardiovascular risk: evaluate history of thrombosis or clotting disorders.
  • Evaluate liver function: perform baseline hepatic enzymes and monitor periodically.
  • Avoid use in pregnancy: drug is contraindicated due to teratogenic potential.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light.

Avoid Interactions

Letrozole can interact with other medicines, affecting its efficacy or safety profile.

Major Interactions (Avoid)

  • Estrogen replacement therapy: negates estrogen suppression.
  • Strong CYP3A4 inducers (e.g., rifampin): markedly reduce plasma levels.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase exposure and toxicity.
  • Tamoxifen co‑administration: may diminish therapeutic effect.
  • Concurrent aromatase inhibitors: duplicate pharmacologic action.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (warfarin): enhanced anticoagulant effect.
  • SSRIs affecting platelet function: potential bleeding risk.
  • Statins metabolized by CYP3A4: altered concentrations.
  • Diuretics causing electrolyte shifts: monitor potassium.
  • Anticonvulsants (carbamazepine): may lower letrozole levels.

Frequently Asked Questions

Letrozol Genthon is a generic formulation of letrozole, an aromatase inhibitor indicated for the treatment of hormone‑sensitive breast cancer in postmenopausal women. It is used both in advanced disease settings and as adjuvant therapy after surgery to reduce the risk of cancer recurrence. The drug works by lowering estrogen levels, which can slow tumor growth.

Letrozole works by reversibly binding to the aromatase enzyme (CYP19A1) in peripheral tissues, blocking the conversion of androgens such as androstenedione and testosterone into estrone and estradiol. This reduction in circulating estrogen deprives estrogen‑receptor positive tumor cells of a key growth signal, thereby inhibiting proliferation.

The specific dose of Letrozol Genthon is determined by the prescribing oncologist based on clinical guidelines, patient weight, liver function and treatment goals. Typically, an oral tablet is taken once daily, but the exact strength and schedule must be confirmed by the treating physician. Dosage adjustments may be required for hepatic impairment.

Letrozole is contraindicated during pregnancy because suppression of estrogen can interfere with fetal development and cause birth defects. It is also not recommended for breastfeeding mothers, as the drug may be excreted in milk and affect the infant. Women of child‑bearing potential must use effective contraception throughout treatment.

To order Letrozol Genthon, visit the product page on gnhindia.com and submit an enquiry specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Letrozole belongs to the aromatase inhibitor class and is often compared with other agents such as anastrozole and exemestane. All three provide potent estrogen suppression, but letrozole is considered slightly more potent in some studies. Compared with tamoxifen, an estrogen receptor modulator, letrozole has a lower risk of endometrial changes but a higher incidence of joint pain and hot flashes.

Letrozol Genthon tablets should be stored at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the medication out of reach of children and do not use any tablets that appear discoloured, broken or damaged.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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