Product image of Letrozol Medical Valley (Letrozole) supplied by GNH India

Letrozol Medical Valley

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Medical Valley (Letrozole)

Letrozole, the active ingredient in Letrozol Medical Valley, is a selective non‑steroidal aromatase inhibitor presented as an oral tablet for oral use. It is indicated for the treatment of postmenopausal hormone receptor‑positive breast cancer, helping to reduce estrogen‑driven tumor growth. The product complies with EU regulatory standards and is manufactured under strict quality controls.

GNH India supplies Letrozol Medical Valley as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medical Valley Invest Ab

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Indications & Clinical Uses

Letrozole is used in endocrine therapy targeting estrogen‑dependent breast cancer.

  • Postmenopausal hormone receptor‑positive breast cancer: reduces recurrence and disease progression.
  • Adjuvant therapy after surgery: decreases risk of cancer returning.
  • Metastatic breast cancer: helps control tumor growth.

How It Works

  • Letrozole selectively and non‑steroidally inhibits the aromatase enzyme, which converts androgens to estrogens. By blocking aromatase, systemic estrogen synthesis is markedly reduced, limiting the growth stimulus for estrogen‑dependent breast cancer cells and slowing tumor progression.

Side Effects

Letrozole may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Hot flashes: transient feeling of warmth and sweating.
  • Joint and muscle pain: aching in joints or muscles.
  • Fatigue: persistent tiredness.
  • Nausea: mild stomach upset.
  • Headache: mild to moderate pain.
  • Dizziness: sensation of light‑headedness.

Serious or Rare Side Effects

  • Severe liver injury: elevated liver enzymes or hepatitis.
  • Bone fracture: increased risk of osteoporosis‑related fractures.
  • Deep vein thrombosis or pulmonary embolism: clot formation in veins.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Cardiac arrhythmia: QT interval prolongation.

Precautions & Warnings

When prescribing letrozole, clinicians should consider several safety precautions.

  • Bone health monitoring: assess bone mineral density regularly.
  • Liver function monitoring: check hepatic enzymes periodically.
  • Lipid profile monitoring: evaluate cholesterol levels during treatment.
  • Pregnancy contraindication: avoid use in pregnant women (Category X).
  • Premenopausal use: not indicated for premenopausal patients.
  • Store at ambient temperature: keep in original packaging, protect from moisture.

Avoid Interactions

Letrozole can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Tamoxifen: concurrent use may reduce therapeutic effect of both agents.
  • Estrogen replacement therapy: counteracts letrozole’s action.
  • Strong CYP2A6 inhibitors (e.g., methoxsalen): may increase letrozole levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., rifampin): may lower letrozole concentrations.
  • CYP3A4 inhibitors (e.g., ketoconazole): may raise letrozole levels.
  • Anticoagulants (e.g., warfarin): may increase bleeding risk.

Frequently Asked Questions

Letrozol Medical Valley contains letrozole, an aromatase inhibitor used in endocrine therapy for postmenopausal women with hormone receptor‑positive breast cancer. It helps lower estrogen levels, thereby slowing the growth of estrogen‑dependent tumors.

Letrozole blocks the aromatase enzyme, which converts adrenal and ovarian androgens into estrogen. By inhibiting this conversion, systemic estrogen production drops, reducing the hormonal stimulus that drives the growth of certain breast cancers.

The dosage of letrozole is determined by the prescribing physician based on the patient’s clinical condition, treatment setting and regulatory guidelines. Patients should follow the exact regimen provided by their healthcare professional.

Letrozole is classified as pregnancy category X, meaning it is contraindicated during pregnancy because it can harm the fetus. It is also not recommended for breastfeeding mothers, as it may be excreted in breast milk and affect the infant.

To order Letrozol Medical Valley, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole, anastrozole and exemestane are the three main aromatase inhibitors. Letrozole is a non‑steroidal, highly selective inhibitor with a long half‑life, often chosen for its potency in reducing estrogen levels. Choice among them depends on patient tolerance, prior therapy and physician preference.

Letrozol Medical Valley should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain its stability.

The medication is taken orally, usually as a tablet swallowed with water. Patients should follow the dosing schedule prescribed by their healthcare provider and take the drug consistently each day to maintain steady drug levels.

Serious risks include severe liver injury, osteoporosis‑related fractures, deep‑vein thrombosis or pulmonary embolism, and rare allergic reactions such as anaphylaxis. Patients should be monitored regularly for signs of these conditions and report any concerning symptoms promptly.

Letrozole should not be used by pregnant or breastfeeding women, premenopausal patients, individuals with known hypersensitivity to letrozole or other aromatase inhibitors, and patients with severe liver impairment without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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