Product image of Letrozol Omet Pharma (Letrozole) supplied by GNH India

Letrozol Omet Pharma

Active Ingredient:
Letrozole
Origin:
EU

Letrozol Omet Pharma (Letrozole)

Letrozole, the active ingredient in Letrozol Omet Pharma, is an aromatase inhibitor presented as an oral tablet for oral use. By selectively blocking the aromatase enzyme, it lowers peripheral conversion of androgens to estrogens, thereby decreasing circulating estrogen levels. It is indicated for the management of hormone receptor‑positive breast cancer in postmenopausal women.

GNH India supplies Letrozol Omet Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals and pharmacies worldwide, adhering to EU quality standards and regulatory requirements.

Manufacturer / TM Owner

Omet Pharma Ab

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Indications & Clinical Uses

Letrozole is used in the hormonal therapy pathway for estrogen‑dependent breast cancer.

  • Hormone receptor‑positive early‑stage breast cancer: reduces risk of recurrence after surgery.
  • Hormone receptor‑positive metastatic breast cancer: slows disease progression in postmenopausal patients.
  • Adjuvant treatment of postmenopausal breast cancer: improves disease‑free survival when given after primary therapy.

How It Works

  • Letrozole selectively inhibits the aromatase enzyme (CYP19A1), which catalyzes the conversion of androstenedione and testosterone to estrone and estradiol. By binding to the enzyme’s active site, it prevents estrogen synthesis in peripheral tissues, leading to markedly reduced circulating estrogen concentrations. The lowered estrogen environment diminishes stimulation of estrogen‑dependent tumor cells, thereby inhibiting their growth and proliferation.

Side Effects

Letrozole may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hot flashes: sudden warmth and sweating.
  • Joint and muscle pain: arthralgia and myalgia.
  • Fatigue: persistent tiredness.
  • Nausea: mild to moderate upset stomach.

Serious or Rare Side Effects

  • Severe liver injury: jaundice or marked enzyme rise.
  • Bone fracture: due to reduced bone density.
  • Pulmonary embolism: sudden breathlessness and chest pain.
  • Allergic reaction: rash, angioedema, or anaphylaxis.

Precautions & Warnings

Before initiating therapy, several safety considerations should be reviewed.

  • Bone health monitoring: assess bone mineral density regularly.
  • Liver function testing: check hepatic enzymes before and during therapy.
  • Cardiovascular risk assessment: evaluate history of thrombosis or heart disease.
  • Hypersensitivity screening: discontinue if signs of allergic reaction appear.
  • Pregnancy avoidance: drug is contraindicated in pregnancy; ensure effective contraception.
  • Store at below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Letrozole can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce letrozole exposure.
  • Estrogen‑containing hormonal therapy (e.g., hormone replacement therapy): antagonizes therapeutic effect.
  • Concurrent use with tamoxifen: may diminish efficacy of both agents.

Moderate Interactions (Monitor Closely)

  • Anticoagulants such as warfarin: letrozole may alter INR, requiring closer monitoring.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine): potential for modest pharmacokinetic changes.
  • Statins (e.g., simvastatin): may increase risk of muscle toxicity.

Frequently Asked Questions

Letrozol Omet Pharma contains letrozole, an aromatase inhibitor indicated for the treatment of hormone receptor‑positive breast cancer in postmenopausal women. It is used in both early‑stage (adjuvant) and metastatic settings to reduce estrogen‑driven tumor growth.

Letrozole works by selectively blocking the aromatase enzyme, which converts androgens into estrogens in peripheral tissues. This inhibition leads to a marked reduction in circulating estrogen levels, depriving estrogen‑dependent cancer cells of the hormone stimulus needed for their proliferation.

The specific dose of Letrozol Omet Pharma is determined by the prescribing clinician based on the patient’s clinical condition, treatment stage, and individual factors. Healthcare professionals follow approved dosing guidelines and adjust as needed for safety and efficacy.

Letrozole is classified as contraindicated in pregnancy because it can interfere with fetal development. Women of child‑bearing potential should use effective contraception during treatment. Safety during breastfeeding has not been established, and breastfeeding is generally not recommended while on letrozole.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Letrozole, anastrozole and exemestane are the three main aromatase inhibitors used in postmenopausal breast cancer. Letrozole generally provides slightly higher estrogen suppression, which can translate into marginally better disease‑free survival in some studies, while anastrozole is often preferred for its once‑daily dosing and exemestane for its steroidal structure. Choice depends on physician judgment, patient tolerance and specific clinical scenarios.

Store Letrozol Omet Pharma at temperatures below 25 °C in its original container, protecting it from moisture, direct sunlight and excessive heat. Keep the tablet blister pack sealed until use and avoid exposing the product to humidity to maintain potency.

Letrozol Omet Pharma is taken orally, usually as a whole tablet swallowed with water. It is typically taken once daily, at the same time each day, with or without food, as directed by the prescribing healthcare professional.

Serious adverse events include severe liver injury, bone fractures due to decreased bone mineral density, pulmonary embolism, and severe allergic reactions such as anaphylaxis. Patients should be monitored regularly for signs of these conditions, and treatment should be stopped if any serious reaction occurs.

Letrozol Omet Pharma should not be used in premenopausal women, pregnant or breastfeeding individuals, patients with known hypersensitivity to letrozole, or those with severe hepatic impairment. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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